| Derek Magill Darby Ltd | Arts & recreation | 2016 |
| Deringer Offshore Services Ltd | Professional & scientific | 2016 |
| Derla Limited | Information & communication | 2011 |
| Derlingrange Limited | Real estate | 1976 |
| DERM4PC Ltd | Health & social care | 2016 |
| Derma & Plastics Ltd | Health & social care | 2022 |
| Derma Cosmedic Aesthetics & Training Ltd | Health & social care | 2021 |
| Derma Couture Ltd | Other services | 2023 |
| Dermanurse Clinic Ltd | Health & social care | 2026 |
| Dermaware Ltd | Information & communication | 2022 |
| Dermotanical Ltd | Manufacturing | 2023 |
| Deroiste Healthcare Limited | Health & social care | 2025 |
| Derry Mathews Academy CIC | Arts & recreation | 2021 |
| Derryman Transport Ltd | Transport & logistics | 2026 |
| Derwent Build 2019 Limited | Construction | 2019 |
| Derwent Buy to LET Limited | Real estate | 2019 |
| Derwent Court Residents Association Limited | Households | 2002 |
| Derwent Lodge Estates Association Limited | Households | 1973 |
| Derwent Lodge Estates Limited | Real estate | 1972 |
| Derwent Pubs Limited | Real estate | 2021 |
| Derwent Real Estate Investments Ltd | Real estate | 2022 |
| Dery Community Centre CIC | Education | 2024 |
| Deryn Alison Ltd | Information & communication | 2022 |
| DES Northwest Ltd | Wholesale & retail | 2023 |
| Desbloque Health Care Ltd | Administrative & support | 2022 |
| Deshapeables Concept UK Limited | Wholesale & retail | 2021 |
| Deshi Khana Takeaway(Flintshire) Ltd | Hospitality | 2016 |
| Desi Dog Boutique Ltd | Wholesale & retail | 2025 |
| Desi Khana L19 Ltd | Hospitality | 2026 |
| Design 4 Life Tattoo Ltd | Other services | 2005 |
| Design and Software Solutions Limited | Information & communication | 2007 |
| Design Consulting Ltd | Professional & scientific | 2008 |
| Design Erect Inspection Scaffolding Ltd | Construction | 2021 |
| Design Property Management Solutions Ltd | Real estate | 2019 |
| Design Soft Technologies Limited | Information & communication | 2023 |
| Design Sustainable Solutions Ltd | Professional & scientific | 2021 |
| Design Week Ltd | Information & communication | 2024 |
| Designadress.Co.Uk Ltd | Manufacturing | 2022 |
| Designandfish Ltd | Professional & scientific | 2022 |
| Designer Craft Gallery UK Limited | Wholesale & retail | 2024 |
| Designer Diffusers Ltd | Manufacturing | 2025 |
| Designer Sale Store Ltd | Wholesale & retail | 2009 |
| Designs Planning Design Limited | Professional & scientific | 2016 |
| Designscope Ltd | Extraterritorial | 2008 |
| DESIGNTSHIRTS2018 Ltd | Wholesale & retail | 2020 |
| Desimas Ltd | Wholesale & retail | 2026 |
| Desire Estates Merseyside Ltd | Real estate | 2021 |
| Desmond & Shaw Letting Agents Limited | Real estate | 2020 |
| Desmond L Bannon & Sons Ltd | Other services | 2012 |
| Desmond Property Ltd | Real estate | 2021 |
| Dess Developments Limited | Real estate | 2021 |
| Dessert & Shakes L8 Ltd | Wholesale & retail | 2026 |
| Dessert G1 Limited | Hospitality | 2025 |
| Dessert G2 Limited | Hospitality | 2025 |
| Dessert LAB Ltd | Wholesale & retail | 2026 |
| Desta Restaurant Ltd | Hospitality | 2026 |
| Destiny BDR Limited | Arts & recreation | 2022 |
| Detail Clean Solutions Limited | Administrative & support | 2016 |
| Detail Gardening Ltd | Administrative & support | 2026 |
| Detailed Property Services Limited | Construction | 2026 |
| Detailworks Property Services Ltd | Real estate | 2026 |
| Deterministic Holdings Limited | Information & communication | 2025 |
| Detour Bar Limited | Hospitality | 2024 |
| Detrafford City Gardens Ltd | Administrative & support | 2015 |
| Detrafford Sky Gardens Ltd | Administrative & support | 2014 |
| Detrafford ST Georges Gardens Ltd | Administrative & support | 2015 |
| DEV Convenience & Discount Booze Ltd | Wholesale & retail | 2021 |
| DEV Sports Ltd | Information & communication | 2018 |
| Deva Estates Limited | Real estate | 1989 |
| Deva Fest Ltd | Hospitality | 2019 |
| Devacom Limited | Real estate | 2007 |
| Devaplan Ltd | Other services | 2004 |
| Develop Liverpool Limited | Administrative & support | 2019 |
| Developing Enhanced Living Services Limited | Real estate | 2023 |
| Developing Star Training Ltd | Health & social care | 2020 |
| Devereux Finance Limited | Professional & scientific | 2023 |
| Deviate Studio Limited | Arts & recreation | 2015 |
| Device Merseyside Ltd | Wholesale & retail | 2024 |
| Devine Cleaning Ltd | Other services | 2015 |
| Devine Hospitality Limited | Hospitality | 2019 |
| Devine Investments Ltd | Financial services | 2020 |
| Devine NRG Liverpool Ltd. | Construction | 2022 |
| Devine Rescue Medic Limited | Health & social care | 2018 |
| Devlin Hayden Ltd | Hospitality | 2024 |
| Devlon Investments Limited | Real estate | 2001 |
| Devon Leaf Limited | Hospitality | 2018 |
| Devon Market Ltd | Wholesale & retail | 2025 |
| Devon Stores Ltd | Wholesale & retail | 2016 |
| Devonportpainting Ltd | Construction | 2025 |
| Devonshire Hospitality Services Ltd | Hospitality | 2025 |
| Devonshire Mews (Liverpool) Management Company Limited | Households | 2009 |
| Devonshire Residents Ltd | Households | 2021 |
| Devzenix Limited | Wholesale & retail | 2025 |
| DEW Course Deliveries Limited | Transport & logistics | 2025 |
| Dewsbury Construction Limited | Construction | 2023 |
| DEX MED Ltd | Health & social care | 2019 |
| Dexal Ltd | Information & communication | 2025 |
| Dexora Ltd | Wholesale & retail | 2025 |
| Dexter Plant Ltd | Water & waste | 2017 |
| Dextra Building and Joinery Specialists Ltd | Construction | 2025 |