| Design Packaging Group Limited | Manufacturing | 1988 |
| Designer Music Limited | Information & communication | 1987 |
| Designforge Automation Ltd | Information & communication | 2024 |
| Developing Smarter Limited | Administrative & support | 2019 |
| Devon Land Holdings Limited | Wholesale & retail | 1972 |
| DGT Accounting Ltd | Professional & scientific | 2020 |
| DHC Hotels Ltd | Hospitality | 2021 |
| Dian's Auto Care Ltd | Wholesale & retail | 2026 |
| Dice & Games Distribution Ltd | Wholesale & retail | 2010 |
| Didi Productions Limited | Administrative & support | 2013 |
| Digital Mike Ltd | Information & communication | 2021 |
| Digital Networking Corporation Ltd | Administrative & support | 2017 |
| Dineware Limited | Extraterritorial | 2007 |
| Dinsdale Young Consultants Ltd | Professional & scientific | 2011 |
| Dipa Shah Limited | Health & social care | 2011 |
| Direct Plumbing Supplies Ltd | Wholesale & retail | 2020 |
| Discount Vehicle Testing Centre Ltd | Wholesale & retail | 2023 |
| District Nine Autos Ltd | Wholesale & retail | 2022 |
| Ditchling Estates Limited | Real estate | 2021 |
| DJH Leadworks Ltd | Construction | 2021 |
| DM Southern Ltd | Hospitality | 2015 |
| DMH Property Ltd | Administrative & support | 2014 |
| DMH Trading Limited | Wholesale & retail | 2011 |
| DO Projects Ltd | Arts & recreation | 2015 |
| Doctor B Limited | Health & social care | 2019 |
| Dolca Engineering Ltd | Construction | 2019 |
| Dolphin Court (Rustington) Limited | Households | 1995 |
| Dominic Grant Ltd | Professional & scientific | 2021 |
| Domnyah Ltd | Wholesale & retail | 2021 |
| Dorset House Residents Association Limited | Professional & scientific | 2005 |
| Dosing Systems Limited | Manufacturing | 1994 |
| Double Busy Ltd | Information & communication | 2014 |
| Dove (Littlehampton) Ltd | Hospitality | 2002 |
| Dowal Walker Limited | Administrative & support | 1998 |
| Down to Earth Studios Ltd | Education | 2020 |
| Down to Earth Yoga Ltd | Education | 2014 |
| Downside Court Limited | Households | 1986 |
| Downsview Developments Limited | Construction | 2010 |
| Downsview Residents Association Management Limited | Hospitality | 1990 |
| Downsway Development Limited | Construction | 2026 |
| DPB Contracting Ltd | Information & communication | 2021 |
| DR Hunter Aesthetics Limited | Other services | 2023 |
| DR Karaoke Community Interest Company | Arts & recreation | 2026 |
| Dragon Industries Investments Limited | Financial services | 2020 |
| Drayton FEN Limited | Professional & scientific | 2013 |
| Dream Motors PVT Ltd | Wholesale & retail | 2023 |
| Dreamtech Competitions Ltd | Arts & recreation | 2019 |
| Drill Hall Portsmouth Limited | Financial services | 2017 |
| Du-Bek Accounting & Bookkeeping Services Limited | Professional & scientific | 2023 |
| Duma Partners Ltd | Professional & scientific | 2025 |
| Duncan Stewart Textiles Limited | Wholesale & retail | 2001 |
| Dunsfold Securities Ltd. | Professional & scientific | 2001 |
| Duodrive Logistics Ltd | Wholesale & retail | 2022 |
| Durrington Festival Ltd | Professional & scientific | 2024 |
| Duthu Ltd | Professional & scientific | 2018 |
| DVR Haulage Services Ltd | Transport & logistics | 2019 |
| Dynamic Cloud Services Limited | Information & communication | 2011 |
| Dynoc Limited | Professional & scientific | 2004 |
| DZA Technical EOT Limited | Professional & scientific | 2025 |
| DZA Technical Limited | Administrative & support | 2001 |
| E J Moyle LLP | | 2013 |
| E.W Logistics Ltd | Transport & logistics | 2025 |
| E.W Retail Ltd | Wholesale & retail | 2024 |
| Eagle Brewery Management Limited | Households | 2016 |
| Earnhouse Ltd | Information & communication | 2026 |
| Earthforce Lightning Protection Ltd | Professional & scientific | 2024 |
| East of the River Sussex Limited | Hospitality | 2023 |
| East Preston Architectural Ltd | Professional & scientific | 2018 |
| East Preston Business Services Ltd | Professional & scientific | 2024 |
| East Preston Festival Committee CIC | Arts & recreation | 2024 |
| East Preston Stays Ltd | Hospitality | 2025 |
| East Preston Village Preschool Ltd | Education | 2026 |
| East Street Coffee Limited | Hospitality | 2025 |
| Easy Access Bathing Ltd | Administrative & support | 2020 |
| Easy Pools Limited | Wholesale & retail | 2000 |
| Eaton Court (Freehold) Limited | Households | 2008 |
| Ebiko Ltd | Professional & scientific | 2023 |
| Ebony Group Ltd | Real estate | 2023 |
| Eccopop Ltd | Information & communication | 2025 |
| Echologika Holdings Ltd | Financial services | 2018 |
| Echologika Ltd | Water & waste | 2018 |
| Eco Action Partnership Limited | Professional & scientific | 2009 |
| Eco Contractors Europe Ltd | Construction | 2014 |
| Eden CAD Services Direct Ltd | Construction | 2011 |
| Edgcumbe Tea & Coffee Company Limited | Manufacturing | 1990 |
| Edwins Food Ltd | Hospitality | 2025 |
| Efexia UK Limited | Financial services | 2020 |
| EJG International Ltd | Transport & logistics | 2024 |
| EK Commercial Limited | Administrative & support | 2026 |
| EK Field Ltd | Wholesale & retail | 2017 |
| Ek&Co Ltd | Financial services | 2026 |
| EKO Barbers Ltd | Other services | 2022 |
| Elderwood Residents Association Limited | Households | 1984 |
| Electrical Sense Ltd | Construction | 2018 |
| Elevare Estates Management Limited | Real estate | 2025 |
| Eleven Carpentry & Construction Limited | Construction | 2024 |
| Elite Domestic Builders Limited | Construction | 2025 |
| ELJAYS44 Ltd | Information & communication | 2011 |
| ELM Court (UK) Limited | Households | 1998 |
| Elsie Joan Ltd | Real estate | 2009 |