| Dornans Paving & Landscapes Ltd | Administrative & support | 2025 |
| Douglas Property & Storage Ltd | Real estate | 2025 |
| Down Royal Day Care Ltd | Health & social care | 2023 |
| Down Royal Park Racecourse Limited | Arts & recreation | 2018 |
| DP Payroll Services Ltd | Information & communication | 2019 |
| DR Electrical Services N.I. Ltd | Construction | 2025 |
| DR Green Tree Care Ltd | Agriculture & fishing | 2019 |
| DR S M Medics Ltd | Health & social care | 2026 |
| DR Tanya Kane Ltd | Health & social care | 2019 |
| Dragon Eventus Ltd | Arts & recreation | 2025 |
| Drayne's Dairy Limited | Wholesale & retail | 2025 |
| Drayne's Group Limited | Financial services | 2025 |
| Dream Designs Group Ltd | Professional & scientific | 2021 |
| Dreambuildni Ltd | Construction | 2026 |
| Drennan Equestrian Limited | Agriculture & fishing | 2023 |
| DRG Assets Ltd. | Manufacturing | 2022 |
| Drip Culture GUN Ltd | Wholesale & retail | 2026 |
| Drivebuddy Group Ltd | Information & communication | 2025 |
| Drumballyroney Heritage C.I.C. | Education | 2022 |
| Drumbeg Mews Limited | Households | 2019 |
| Drumbo Smith & Engineering Works Limited | Manufacturing | 1966 |
| Drumhill Tractors (Lisburn) Ltd | Manufacturing | 2023 |
| Drumhill Tractors Limited | Manufacturing | 2001 |
| Drummond Reid Ltd | Construction | 2015 |
| Drumvale Investments Limited | Real estate | 2010 |
| DRY Risers N.I. Limited | Construction | 2018 |
| DS Auto Performance Ltd | Wholesale & retail | 2024 |
| Duct & Scientific Services Limited | Manufacturing | 2001 |
| Dumac LLP | | 2011 |
| Dunbridge Ltd | Real estate | 2013 |
| Dundrod and District Motorcycle Club Limited | Arts & recreation | 1989 |
| Dunnaree Hill Wind Farm Ltd | Energy | 2026 |
| Dunounly Ltd | Wholesale & retail | 2026 |
| Dunrock Limited | Administrative & support | 2011 |
| Dusishidan World Co Limited | Wholesale & retail | 2026 |
| DW & J Enterprises Limited | Wholesale & retail | 2017 |
| Dynamic Electrical Systems Ltd | Construction | 2017 |
| Dynamit Sales LP | | 2017 |
| E-Pink Image Co Limited | Wholesale & retail | 2026 |
| E-Sell Agency LP | | 2020 |
| E-Tech Boiler Services Ltd | Manufacturing | 2018 |
| E.A. Property (NI) Limited | Real estate | 2003 |
| EA Retail Group Ltd | Wholesale & retail | 2019 |
| Eachros Ltd | Wholesale & retail | 2023 |
| Eaglewood Contracts Ltd. | Construction | 2018 |
| Earlscourt Property and Development Ltd | Construction | 2018 |
| Early Systems & Technologies LLP | | 2017 |
| Earney Contracts (NI) Limited | Real estate | 2008 |
| Earney Contracts Limited | Construction | 1976 |
| Earney Properties NI Ltd | Real estate | 2020 |
| Easability Showers Limited | Manufacturing | 1993 |
| Eastwood Funeral Directors (Crumlin) Ltd | Other services | 2018 |
| Ebenezer Residence Ltd | Hospitality | 2023 |
| Ebony (Lisburn) Limited | Administrative & support | 2010 |
| Ebony Developments Limited | Real estate | 2005 |
| ECL Electrical Ltd | Construction | 2024 |
| Ecoat Ireland Limited | Manufacturing | 1987 |
| Ecoformix Ltd | Information & communication | 2024 |
| Ecohealth Ltd | Wholesale & retail | 2024 |
| Ecosealni Ltd | Construction | 2019 |
| Ecostar Energy LLP | | 2021 |
| Eden Bloodstock Limited | Agriculture & fishing | 2019 |
| Edenfells Properties Ltd | Real estate | 2007 |
| Edenmar Trading Ltd | Wholesale & retail | 2004 |
| Edentrillick Quarries Limited | Mining & quarrying | 1987 |
| Edgar #52 Limited | Other services | 2022 |
| Edge Sports Ltd | Information & communication | 2026 |
| Edgeform Fabrications Limited | Manufacturing | 2000 |
| Edina Power Limited | Manufacturing | 2003 |
| EF Plumbing & Heating Ltd | Construction | 2020 |
| Efemile Limited | Hospitality | 2024 |
| Effective Engineering Systems Limited | Professional & scientific | 2020 |
| Eglia Ltd | Health & social care | 2016 |
| Elco Developments Limited | Construction | 2004 |
| Electric Vehicle Association Northern Ireland CIC | Other services | 2021 |
| Electrical Drawing Services Limited | Professional & scientific | 2017 |
| Electro Automation (N.I.) Limited | Manufacturing | 1985 |
| Electronic Document Management Consultancy Ltd | Information & communication | 2011 |
| Elite Business Solutions 2019 Ltd | Wholesale & retail | 2019 |
| Elite Construction & Shopfitting Ltd | Construction | 2013 |
| Elite Fit OUT Limited | Construction | 2011 |
| Elite Shopfitting and Construction Limited | Construction | 2011 |
| Elite Training (NI) Limited | Professional & scientific | 2013 |
| Elite Training and Consultancy Services Ltd | Information & communication | 1994 |
| Elixa Health Ltd | Wholesale & retail | 2023 |
| Elliott MSK Radiology Ltd | Health & social care | 2010 |
| ELM Meadows Company Limited | Financial services | 2015 |
| Elmt Ltd | Financial services | 2025 |
| Elora Living Ltd | Real estate | 2025 |
| ELP Ltd | Administrative & support | 2024 |
| ELS Autos Ltd | Wholesale & retail | 2020 |
| ELV Contracts Ltd | Professional & scientific | 2024 |
| Elysium Properties (N.I.) Limited | Construction | 2024 |
| EMA Systems Integration Limited | Information & communication | 2002 |
| Embedded Monitoring Systems Limited | Professional & scientific | 2003 |
| Embroidery 4 Trade Ltd | Manufacturing | 2018 |
| Emerald Invest LP | | 2017 |
| Emerald Property Management Ltd | Construction | 2017 |
| Emmett Fitzpatrick Tractors Limited | Wholesale & retail | 2011 |
| Empire Holdings (U.K.) Limited | Construction | 2015 |