| Splinter New Build Quality Inspections Ltd | Construction | 2021 |
| Spookfish Limited | Administrative & support | 2013 |
| Sports Plus Scheme Limited | Arts & recreation | 2005 |
| Spurge Ltd | Information & communication | 2025 |
| Squarelabs Limited | Manufacturing | 2014 |
| Squealing PIG Guitars Ltd | Wholesale & retail | 2020 |
| Squires Site Services Ltd | Construction | 2015 |
| SR Engineering & Installation Services Limited | Construction | 2025 |
| SR Interiors and Rendering Ltd | Construction | 2025 |
| SRI Create Limited | Health & social care | 2010 |
| SRL 2021 Limited | Financial services | 2020 |
| SRM Express Couriers Limited | Transport & logistics | 2014 |
| SRS (Midlands) Ltd | Construction | 2019 |
| SSG Insight (Emea) Limited | Information & communication | 1983 |
| SSG Insight Limited | Extraterritorial | 2001 |
| SSG Insight Technologies Limited | Information & communication | 1985 |
| SSI Midlands Limited | Professional & scientific | 2025 |
| Ssla Trading Company Ltd | Wholesale & retail | 2024 |
| ST Chad's Retreat Centres | Other services | 2014 |
| ST John's Hill (Shenstone) Management Company Limited | Households | 2009 |
| ST Johns House (Staffordshire) Limited | Hospitality | 2011 |
| ST Matthews Support Services Ltd | Health & social care | 2015 |
| ST. Chads Rectory Tenants Association Limited | Professional & scientific | 1978 |
| ST. Giles Hospice | Health & social care | 1979 |
| ST. Giles Hospice (Promotions) Limited | Information & communication | 1996 |
| ST. Mary's Centre Lichfield (Shops) Limited | Arts & recreation | 1993 |
| Stable Gardens (Fritwell) Management Company Limited | Households | 2023 |
| Stables Living Ltd | Hospitality | 2020 |
| Stadiatech Ltd | Manufacturing | 2024 |
| STAFF4DSHIRE Scaffolding Ltd | Construction | 2022 |
| Stafford Ryan Limited | Professional & scientific | 2018 |
| Staffordshire Conservatories Ltd | Construction | 2025 |
| Staffordshire Furniture Limited | Wholesale & retail | 2023 |
| Staffordshire Herbs Ltd | Agriculture & fishing | 2019 |
| Staffordshire Network for Mental Health Ltd | Health & social care | 2003 |
| Staffordshire Refrigeration and Air Conditioning Ltd | Manufacturing | 2019 |
| Staffordshire Restoration and Conservation Ltd | Construction | 2007 |
| Staffordshire Seeding Contractors Limited | Agriculture & fishing | 2024 |
| Staffordshire Winter Sports Club Limited | Arts & recreation | 2012 |
| Stag Consultancy Ltd | Professional & scientific | 2021 |
| Stamp Associates Limited | Administrative & support | 2010 |
| Standem Properties Ltd | Real estate | 2015 |
| Stanhope Residents Association Limited | Households | 2001 |
| Stanley Edens (UK) Limited | Extraterritorial | 2000 |
| Star Commercial & Domestic Cleaning Group Ltd | Administrative & support | 2022 |
| Star Taxis Lichfield Ltd | Transport & logistics | 2025 |
| Stara Safety Limited | Administrative & support | 2012 |
| Starjobs UK Ltd | Administrative & support | 2020 |
| Starkle Limited | Administrative & support | 1979 |
| Starsourcinguk Ltd | Wholesale & retail | 2022 |
| Start Over Solutions Ltd | Health & social care | 2026 |
| Startin Farms Limited | Agriculture & fishing | 1966 |
| Startin Tractors Limited | Wholesale & retail | 1978 |
| Staxf Ltd | Information & communication | 2013 |
| Steaizre Ltd | Administrative & support | 2021 |
| Stealth Management Services Limited | Professional & scientific | 2023 |
| Stec Holdings Ltd | Manufacturing | 2017 |
| Stec Ltd | Manufacturing | 2011 |
| Steeple HAY Limited | Professional & scientific | 2018 |
| Stella Boutique Ltd | Wholesale & retail | 2023 |
| Stellar Properties Limited | Real estate | 2016 |
| Stellar Ventures Limited | Professional & scientific | 2013 |
| Stelrick Homes Limited | Hospitality | 2012 |
| Stelwood Estates Limited | Real estate | 2017 |
| Stephen J Walker Contracting Limited | Information & communication | 2021 |
| Stephen James Property Ltd | Construction | 2018 |
| Stephen William Ling Limited | Extraterritorial | 2022 |
| Stephen.W.Ling. Ltd | Health & social care | 2005 |
| Stepingtand Ltd | Administrative & support | 2022 |
| Sterling AI Limited | Information & communication | 2026 |
| Steve Bayley Services Limited | Transport & logistics | 2018 |
| Stewart Linford Furniture Maker Limited | Manufacturing | 2024 |
| Stockfield Community Association | Real estate | 1991 |
| Stockfield Community Association (Subsidiary) Limited | Real estate | 1991 |
| Stokes Properties MK Ltd | Real estate | 2018 |
| Stone Consulting (UK) Ltd | Education | 2002 |
| Stone Conversions Limited | Construction | 2018 |
| Stonecore Commercial Management Ltd | Professional & scientific | 2026 |
| Stoneyford Estates Limited | Real estate | 2012 |
| Stoneywell (Midlands) Ltd | Construction | 2016 |
| Storm Dezign Ltd | Extraterritorial | 2015 |
| Storm Plumbers Ltd | Construction | 2019 |
| Stour Heath Holdings Ltd | Construction | 2020 |
| Stour Heath Projects Ltd | Professional & scientific | 2022 |
| Stowe & Ager Accountants Limited | Professional & scientific | 2018 |
| Stowe Contracting Limited | Construction | 2019 |
| Strada Investments Ltd | Real estate | 2016 |
| Straightforward Agency Ltd | Professional & scientific | 2025 |
| Straightline-Uk-Snowsports Ltd | Wholesale & retail | 2014 |
| Strandways Court Limited | Real estate | 1991 |
| Stratford Safety Solutions Limited | Professional & scientific | 2025 |
| Stratton Commercial 2024 Limited | Construction | 2024 |
| Stratton Glass Limited | Construction | 2025 |
| Stratton Oakmont Property Ltd | Real estate | 2021 |
| Strawberry Fields Financial Ltd | Professional & scientific | 2026 |
| Strawberrygum Limited | Wholesale & retail | 2010 |
| Strawco Limited | Real estate | 2022 |
| Streethay Wharf Engineering Ltd | Manufacturing | 2016 |
| Streethay Wharf Holdings Ltd | Financial services | 2016 |
| Streethay Wharf Ltd | Manufacturing | 2011 |