| Station Mews Management Company Ltd | Households | 2002 |
| Staverton Oak Management Company Limited | Households | 2018 |
| Stax Sportswear Limited | Transport & logistics | 2019 |
| Stayinsouthernitaly Limited | Energy | 2002 |
| Steadman Development Consultants Limited | Construction | 2020 |
| Steam Powered Productions Ltd | Arts & recreation | 2010 |
| Steed Properties Limited | Real estate | 2024 |
| Steel and Sparks Ltd | Manufacturing | 2025 |
| Steel Line Solutions UK Ltd | Construction | 2024 |
| Stela Consulting Ltd | Information & communication | 2014 |
| Stellar G.M. Ltd | Professional & scientific | 2026 |
| Stellar Technology Ltd | Administrative & support | 2026 |
| Stenic Investments Limited | Financial services | 2025 |
| Sterling Cabs Ltd | Transport & logistics | 2020 |
| Steve Allen Limited | Agriculture & fishing | 2026 |
| Steve COE Limited | Professional & scientific | 2007 |
| Steve Mark Consultancy Ltd | Administrative & support | 2024 |
| Steve Thompson Video Editor Ltd | Information & communication | 2021 |
| Steven Westwick Consulting Limited | Information & communication | 2020 |
| Stewkley Enterprise Agency | Administrative & support | 2014 |
| Stewkley Heating Ltd | Construction | 2025 |
| Stewkley Stone Limited | Manufacturing | 2007 |
| Stewkley Storage Limited | Wholesale & retail | 1995 |
| Sticky Parrot Ltd | Information & communication | 2026 |
| Stirlng Lines Ltd | Transport & logistics | 2015 |
| Stockfields Place Residents Management Company Limited | Households | 2005 |
| Stockgrove Drive Company Limited | Households | 1991 |
| Stockgrove Park Management Limited | Households | 1996 |
| Stocks Road Productions Limited | Professional & scientific | 2025 |
| Stockwell Engineering Ltd | Manufacturing | 2025 |
| Stone & Thompson Ltd | Hospitality | 2025 |
| Stone Recruitment Ltd | Administrative & support | 2024 |
| Stone Town Planning Ltd | Professional & scientific | 2013 |
| Stonecasa Limited | Wholesale & retail | 2019 |
| Stonelaw Property Holdings Limited | Real estate | 2026 |
| Stonemead Gawcott (Management Company) Limited | Households | 2007 |
| Stormont Specialist Services Ltd | Administrative & support | 2003 |
| Strachan 2025 Ltd | Financial services | 2026 |
| Strata Nexus AI Ltd | Information & communication | 2026 |
| Strategic Talent Consulting Ltd | Professional & scientific | 2025 |
| Stratford Andrade Services Limited | Information & communication | 2025 |
| Stratos Creative Limited | Information & communication | 2014 |
| Strawberry Fieldz Ltd | Arts & recreation | 2013 |
| Strength Sports Ltd. | Wholesale & retail | 2012 |
| Striped Horse Consulting Ltd | Professional & scientific | 2022 |
| Strivex Consulting Ltd | Information & communication | 2025 |
| Strode & Budds Ltd | Administrative & support | 2025 |
| Stu's Oven Ltd | Hospitality | 2014 |
| Stuart Brown Mortgage Services Limited | Financial services | 2003 |
| Stuck for Staff Limited | Administrative & support | 2017 |
| Stud Farm Developments Ltd | Construction | 2026 |
| Studio Eight by Tyler-Rose Limited | Other services | 2020 |
| Studio Malpede Ltd | Information & communication | 2025 |
| STUDIO28ZERO Ltd | Professional & scientific | 2026 |
| Studios 7 CIC | Education | 2022 |
| Sugrue Construction Services Ltd | Construction | 2026 |
| Suit-The-Case Development Ltd. | Professional & scientific | 2016 |
| Suleman Business Solutions Ltd | Administrative & support | 2021 |
| Summit Hygiene Limited | Wholesale & retail | 2020 |
| Summit Marketing Limited | Information & communication | 2025 |
| Sunbird Homes Limited | Other services | 2020 |
| Sunbird Marketing Services Limited | Professional & scientific | 2023 |
| Sunfire Software Ltd | Information & communication | 2024 |
| Sunny Surani Limited | Information & communication | 2012 |
| Sunnydale Services Limited | Information & communication | 1994 |
| Sunrise Solutions Limited | Other services | 2007 |
| Sunscape Innovations Ltd | Wholesale & retail | 2020 |
| Sunshine Space Limited | Real estate | 2025 |
| Sunshine Works Ltd | Construction | 2023 |
| Sunzone Tanning Ltd | Other services | 2025 |
| Superabrasive Techniques Limited | Professional & scientific | 1988 |
| Superhero Panda Ltd | Information & communication | 2025 |
| Superpool Ltd | Wholesale & retail | 2016 |
| Supersonika Limited | Professional & scientific | 2018 |
| Superstar Events Limited | Arts & recreation | 2021 |
| Support UK Manufacturing Limited | Information & communication | 2026 |
| Supreme Locum Services Limited | Administrative & support | 2020 |
| Surfnscale Ltd | Wholesale & retail | 2025 |
| Surviscan Limited | Professional & scientific | 2023 |
| Sushi Show Limited | Hospitality | 2014 |
| Sustainability Wright Ltd | Professional & scientific | 2022 |
| Suzaku Consulting Ltd | Information & communication | 2024 |
| Suzie Bidlake Limited | Wholesale & retail | 2009 |
| SV Convention Engineering Solution Ltd | Professional & scientific | 2025 |
| SVR IT Solutions Ltd | Information & communication | 2016 |
| SVR Software Solutions Ltd | Information & communication | 2023 |
| Svst Construction Ltd | Construction | 2012 |
| SW Grips Limited | Information & communication | 2017 |
| Swan Mews (Wendover) Limited | Households | 1990 |
| Sweeney Sutton Roller Ltd | Information & communication | 2019 |
| Swift Electrical SE Ltd | Construction | 2025 |
| Swift Shift Group Ltd | Transport & logistics | 2024 |
| Syfrets Consulting Limited | Professional & scientific | 2018 |
| Sykes Ihlenfeldt Limited | Financial services | 2005 |
| Sykes Ihlenfeldt Wills Ltd | Other services | 2025 |
| Symcos Solutions Limited | Professional & scientific | 2019 |
| Syndicated Ltd | Administrative & support | 2025 |
| Syntax Logistic Ltd | Transport & logistics | 2016 |
| Synxis Ltd | Information & communication | 2018 |
| System Laboratories UK Ltd | Other services | 2020 |