| Sarsons Garage Limited | Wholesale & retail | 2003 |
| Savpen Properties Limited | Real estate | 2007 |
| SC & SC Investments Limited | Real estate | 2023 |
| Scot Young Research (Leics) Limited | Wholesale & retail | 2008 |
| Scratchi & Scratchi Limited | Professional & scientific | 1996 |
| Seagrave Commercial Limited | Wholesale & retail | 2016 |
| Sean Byrne Golf Limited | Wholesale & retail | 2022 |
| Sensibly Zero Limited | Professional & scientific | 2006 |
| Sensing Opco UK Limited | Manufacturing | 2025 |
| Serova Properties Limited | Real estate | 2001 |
| Shanghai Way Limited | Professional & scientific | 2004 |
| Shanti Wellness Limited | Other services | 2026 |
| Shaun Cadden Limited | Construction | 2006 |
| Sheffield & Meredith Ltd | Wholesale & retail | 2003 |
| Shenu Limited | Other services | 2005 |
| Sherwood Property Developments Limited | Extraterritorial | 2007 |
| Shinebright Creative Communications Limited | Professional & scientific | 2002 |
| Shirley Price Aromatherapy Limited | Manufacturing | 2006 |
| Shree Krishnagiri Parshwa Padmavathi | Other services | 2006 |
| Sign 2000 Group Limited | Professional & scientific | 2016 |
| Sign 2000 Holdings Limited | Professional & scientific | 2016 |
| Sign Matrix Ltd | Professional & scientific | 2023 |
| Simknit Limited | Wholesale & retail | 1974 |
| Simon Charles | | 1991 |
| Simple Self Storage Limited | Administrative & support | 2007 |
| Simply HAN Limited | Hospitality | 2002 |
| Simplypay Limited | Professional & scientific | 2002 |
| Sinclair Estate Agents (Coalville) Limited | Real estate | 2006 |
| Sinclair Estate Agents Limited | Real estate | 2005 |
| Sites by SAM Ltd | Information & communication | 2021 |
| SJ & HJ Limited | Professional & scientific | 2006 |
| SJK Limited | Wholesale & retail | 2005 |
| Skiptex Limited | Extraterritorial | 1984 |
| Smart Payment Technologies BID Co Limited | Financial services | 2018 |
| Smart Payment Technologies Hold Co Limited | Financial services | 2006 |
| Smart Payment Technologies Holdings Limited | Financial services | 2018 |
| Smart Payment Technologies Limited | Wholesale & retail | 2002 |
| Smart Payment Technologies Top Co Limited | Financial services | 2018 |
| Smartlabel Solutions Limited | Extraterritorial | 2001 |
| SMC Fabrications Ltd | Manufacturing | 2016 |
| Smith Hannah Limited | Professional & scientific | 2001 |
| Smith Safety Solutions Limited | Professional & scientific | 2006 |
| SMS Construction Chemicals Limited | Construction | 2005 |
| SO Co-Living Ltd | Real estate | 2020 |
| Soar Valley Press Limited | Manufacturing | 1988 |
| Social Work Solutions (Leicester) Limited | Health & social care | 2015 |
| Sofatech Ltd | Other services | 2004 |
| Solarmatch Limited | Wholesale & retail | 1997 |
| Solid Rock Accountancy Limited | Professional & scientific | 2005 |
| Somali Development Services C.I.C. | Other services | 2004 |
| Somerby Financial Solutions Limited | Financial services | 2001 |
| Sonichem Limited | Health & social care | 2000 |
| Sonodrome Ltd | Real estate | 2012 |
| Southview Homes (Leicester) Ltd | Real estate | 2006 |
| Sozu Limited | Information & communication | 2004 |
| Spark and Flow Limited | Construction | 2004 |
| SPK Shah & Co Limited | Professional & scientific | 2002 |
| SPL Blacking Ltd | Manufacturing | 2003 |
| Sport Jewellery Limited | Wholesale & retail | 2002 |
| Sporting Designs Ltd | Manufacturing | 2005 |
| Spread Garden Supplies Limited | Professional & scientific | 1960 |
| Squire Properties & Investments Ltd | Real estate | 2024 |
| Squire Recognition Systems Limited | Wholesale & retail | 1996 |
| SRS Properties Limited | Real estate | 2003 |
| SSC Fleet Services Limited | Manufacturing | 2008 |
| STA Distribution Ltd | Administrative & support | 2011 |
| Stanhope House Day Nursery Limited | Education | 2003 |
| Staniforth Court Management Limited | Households | 1998 |
| Star Travels Limited | Transport & logistics | 2007 |
| Starry Hills Ltd | Administrative & support | 2015 |
| Stemfield Limited | Real estate | 1973 |
| Steve Bifulco Ceramic Tiling Contractors Limited | Construction | 2006 |
| Steve Bosch Ltd | Construction | 2002 |
| Stevensons MOT Centre Limited | Wholesale & retail | 2011 |
| STM Projects Limited | Professional & scientific | 2001 |
| Stormcourt Properties Limited | Real estate | 1998 |
| Stressline (Patents) Limited | Real estate | 1968 |
| Stressline Limited | Manufacturing | 1964 |
| Structured Digital Consulting Ltd | Information & communication | 2026 |
| Stuart Dodd Consulting Ltd | Information & communication | 2000 |
| Studio Enterprise Limited | Professional & scientific | 2000 |
| Sulphur Mills Limited | Extraterritorial | 2005 |
| Sunargow (Broughton Astley) Ltd | Hospitality | 2014 |
| Sunny Heating Limited | Construction | 2002 |
| Supreme Concrete Limited | Manufacturing | 1979 |
| Surespray Coatings (Midlands) Limited | Manufacturing | 2004 |
| Suttons Spiral Supplies Limited | Manufacturing | 2001 |
| SV Surveying Ltd | Construction | 1988 |
| Swift Fitted Furniture Limited | Construction | 2003 |
| Swifton Databases Limited | Information & communication | 2000 |
| Swifts Taxi Contracts Limited | Extraterritorial | 1990 |
| Swithland Estates Limited | Manufacturing | 1998 |
| Sykefield Avenue (NO.2) Management Company Limited | Households | 1992 |
| Symphony Studios Ltd | Education | 2002 |
| Synchemicals Limited | Professional & scientific | 1941 |
| Sytner Carshop Limited | Wholesale & retail | 1986 |
| Sytner Direct Limited | Wholesale & retail | 1998 |
| Sytner Finance Limited | Wholesale & retail | 1989 |
| Sytner Group Limited | Wholesale & retail | 1993 |
| Sytner Holdings Limited | Professional & scientific | 1992 |