| Sanghera Properties Limited | Real estate | 2018 |
| Sangi Ltd | Real estate | 2024 |
| Sangiorgi Consultancy Limited | Professional & scientific | 2016 |
| Sangster Properties LLP | | 2023 |
| Sanguine Wellness Ltd | Other services | 2016 |
| Sanidhya Ltd | Real estate | 2025 |
| Saninrat Thai Spa Ltd | Other services | 2024 |
| Sanipharma Limited | Wholesale & retail | 2025 |
| Saniyah Hussain Ltd | Health & social care | 2024 |
| Sanjay Events (UK) Ltd | Hospitality | 2021 |
| Sanjay Foods (UK) Limited | Wholesale & retail | 2010 |
| Sanjeevani Kitchen Limited | Hospitality | 2025 |
| Sanjha Punjab Leicester Ltd | Wholesale & retail | 2023 |
| Sanjib 8 Limited | Professional & scientific | 2023 |
| Sanjiri Spices Ltd | Wholesale & retail | 2026 |
| Sanjivani Health Ltd | Wholesale & retail | 2025 |
| Sanjog Creations Ltd | Manufacturing | 2024 |
| Sank Construction Ltd | Construction | 2026 |
| Sankalp Ltd | Real estate | 2026 |
| Sanket Trading Limited | Wholesale & retail | 2025 |
| Sankofa Consultancy Services Ltd | Professional & scientific | 1995 |
| Sankofa Events and Promotions Ltd | Arts & recreation | 2021 |
| Sanman Property Management Limited | Professional & scientific | 2016 |
| Sanova Care Ltd | Health & social care | 2025 |
| Sanraj Property Solutions Ltd | Real estate | 2026 |
| Sanray Ltd | Wholesale & retail | 2022 |
| Sansara Properties Limited | Real estate | 2010 |
| Sanshi Investments Limited | Real estate | 2017 |
| Sansom Enterprises (Midlands) Limited | Real estate | 1973 |
| Sansom Property Investments Limited | Real estate | 2021 |
| Sant Girdharanand Paramhans Sant Ashram | Other services | 2017 |
| Santa Removals and Packing Services Ltd | Transport & logistics | 2025 |
| Santal Investments Ltd | Real estate | 2024 |
| Santalijshoteliers Ltd | Hospitality | 2023 |
| Santan Property Limited | Real estate | 2002 |
| Santech Consultancy Ltd | Professional & scientific | 2024 |
| Santech Recruitment Ltd | Administrative & support | 2025 |
| Santex Trading Ltd | Wholesale & retail | 2014 |
| Santhi Leicester Ltd | Hospitality | 2025 |
| Santhi Restaurant Leicester Limited | Hospitality | 2021 |
| Santhouse Pensioneer Trustee Company Limited(The) | Professional & scientific | 1982 |
| Santi Design Ltd | Professional & scientific | 2023 |
| Santnu B Limited | Wholesale & retail | 2025 |
| Santo Healthcare Ltd | Health & social care | 2020 |
| Santok Venture Limited | Real estate | 2025 |
| Santosh Community Centre Community Interest Company | Health & social care | 2011 |
| Santosh Grocery Ltd | Wholesale & retail | 2022 |
| Santoshi MAA Ltd | Real estate | 2023 |
| Sanuaati Limited | Manufacturing | 2022 |
| Sanxpert Digital Ltd | Wholesale & retail | 2024 |
| Saobrasil Limited | Other services | 2020 |
| SAP (Leics) Ltd | Wholesale & retail | 2012 |
| Sapa Connect Ltd | Information & communication | 2025 |
| Sapcote Development Limited | Construction | 2022 |
| Sapcote Garden Centre Limited | Wholesale & retail | 2006 |
| Sapcote Road Burbage Limited | Construction | 2025 |
| Saphala Consulting Ltd | Information & communication | 2025 |
| Saphéa Ltd | Wholesale & retail | 2025 |
| Sapna Foods Limited | Wholesale & retail | 2024 |
| Sapori Restaurant & Bar Limited | Hospitality | 2017 |
| Sapphire Brands Limited | Wholesale & retail | 2010 |
| Sapphire DE Ceylon Ltd | Manufacturing | 2024 |
| Sapphire DNJ Limited | Wholesale & retail | 2023 |
| Sapphire Electrical and Security Solutions Ltd | Construction | 2015 |
| Sapphire Events & Weddings Limited | Arts & recreation | 2016 |
| Sapphire Homecare & Reablement Ltd | Health & social care | 2023 |
| Sapphire Legal Services Ltd | Professional & scientific | 2023 |
| Sapphire Leicester Ltd | Wholesale & retail | 2020 |
| Sapphire Lounge Ltd | Hospitality | 2020 |
| Sapphire Properties Leicester Ltd | Real estate | 2025 |
| Sapphire Rooms Limited | Hospitality | 2018 |
| Sapphire Travel Limited | Administrative & support | 2026 |
| Sapt Limited | Manufacturing | 2025 |
| Saptarshi Limited | Wholesale & retail | 2025 |
| Saqib Traders Ltd | Wholesale & retail | 2025 |
| Saqlain Mushtaq Ltd | Education | 2025 |
| SAR Developments Ltd | Real estate | 2026 |
| SAR Partnership Ltd | Public administration | 2025 |
| Sara (Leicester) Limited | Hospitality | 2016 |
| Sara 1 Ltd | Transport & logistics | 2014 |
| Sara Aesthetic Clinic Ltd | Other services | 2023 |
| Sara and ARA Properties Ltd | Real estate | 2025 |
| Sara Foods (UK) Ltd | Manufacturing | 2006 |
| Sara Holdings (Leicester) Ltd | Real estate | 2018 |
| Sara International Market Ltd | Wholesale & retail | 2022 |
| Sara JM Ltd | Manufacturing | 2020 |
| Saracens Clients Ltd | Wholesale & retail | 2026 |
| Sarah Cornish Barrister Ltd | Professional & scientific | 2026 |
| Sarah Elliott Conveyancing Limited | Other services | 2019 |
| Sarah Heeley Communications Limited | Administrative & support | 2011 |
| Sarah Higgins Corporate Coaching Ltd | Administrative & support | 2011 |
| Sarah Lane Properties Limited | Real estate | 2021 |
| Sarah Mackay Consulting Limited | Hospitality | 2016 |
| Sarah Rachel Boudoir Ltd | Professional & scientific | 2026 |
| Sarah Sear Ltd | Professional & scientific | 2015 |
| Sarah-Marina Limited | Transport & logistics | 2024 |
| Sarahpower Ltd | Administrative & support | 2016 |
| Sarai Construction Leics Limited | Construction | 2019 |
| Sarai Locum Ltd | Health & social care | 2024 |
| Saraj Patel Limited | Wholesale & retail | 1977 |