| Dreme Ltd | Real estate | 2016 |
| Dressingup Limited | Administrative & support | 2018 |
| DRG General Builders Limited | Construction | 2011 |
| DRG Property Investments Ltd | Real estate | 2021 |
| DRI Holdings Limited | Real estate | 2016 |
| DRI Optical Limited | Health & social care | 2005 |
| Drian Andrei Ltd | Transport & logistics | 2018 |
| Drian Petru Trans Ltd | Transport & logistics | 2016 |
| Driffield Management Company Limited | Households | 2024 |
| Drift Care Ltd | Health & social care | 2025 |
| Drift Hub Ltd | Wholesale & retail | 2025 |
| Drift Solutions Ltd | Administrative & support | 2017 |
| Driftwood Design and Build Ltd | Construction | 2023 |
| Driftwood GIN Ltd | Manufacturing | 2023 |
| Drillstyle Limited | Health & social care | 1985 |
| Drinks Chef Consultancy Limited | Professional & scientific | 2021 |
| Drinks Chef Limited | Extraterritorial | 2021 |
| Drip Buy Ltd | Real estate | 2022 |
| Drip Factory Ltd | Wholesale & retail | 2022 |
| Drip&Celebrate Ltd | Hospitality | 2025 |
| Drippin Soda Bar Limited | Wholesale & retail | 2026 |
| Drips and Jabs Ltd | Other services | 2025 |
| Drishti Transportation Ltd | Transport & logistics | 2020 |
| Drive Buddi Ltd | Education | 2016 |
| Drive Contact Centre LLP | | 2012 |
| Drive Eco Solutions Ltd | Professional & scientific | 2025 |
| Drive ILM Ltd | Education | 2026 |
| Drive Mint Ltd | Wholesale & retail | 2026 |
| Drive Motor Properties LLP | | 2010 |
| Drive Motor Retail Limited | Wholesale & retail | 2001 |
| Drive N’ Shine Ltd | Wholesale & retail | 2025 |
| Drive on Hire Ltd | Administrative & support | 2025 |
| Drive Thru Tyer Leicester Ltd | Wholesale & retail | 2022 |
| Drivejet Ltd | Transport & logistics | 2022 |
| Driveline Cars Ltd | Wholesale & retail | 2026 |
| Driver Training Education Ltd | Education | 2023 |
| Drivers Dream Days Limited | Arts & recreation | 2019 |
| Drivers Foods (Leicester) Limited | Manufacturing | 2014 |
| Drivers Pickles Ltd | Manufacturing | 2017 |
| Driveuforward Solutions Limited | Professional & scientific | 2024 |
| Driving Experiences Group Limited | Administrative & support | 2017 |
| Driving Licence Training Academy Ltd | Education | 2024 |
| Driving Talent Limited | Administrative & support | 2017 |
| Driving Wheels Limited | Transport & logistics | 2013 |
| Drizul Limited | Hospitality | 2021 |
| DRK Property Management Limited | Real estate | 2021 |
| DRL Consultancy Services Ltd | Financial services | 2022 |
| DRL Group Limited | Transport & logistics | 2026 |
| DRM Architects Ltd | Professional & scientific | 2020 |
| DRM Studio Ltd | Wholesale & retail | 2025 |
| DRN Financial Ltd | Professional & scientific | 2026 |
| Droginia Limited | Real estate | 2025 |
| Dromader Transports Ltd | Transport & logistics | 2017 |
| Dromkeenuk Ltd | Wholesale & retail | 2025 |
| Drone Sports Ltd | Wholesale & retail | 2023 |
| Drop of Compassion | Health & social care | 2013 |
| Drop Table Ltd | Information & communication | 2021 |
| Droparoll Ltd | Wholesale & retail | 2026 |
| Drplab Limited | Education | 2020 |
| DRR Autos Ltd | Wholesale & retail | 2025 |
| DRS Docrat Limited | Health & social care | 2015 |
| DRT Countryside Limited | Construction | 2024 |
| Drum Architecture Ltd | Professional & scientific | 2026 |
| Drumology ENT Ltd | Arts & recreation | 2024 |
| Drumpark Care Ltd | Health & social care | 2012 |
| Drury Luggage & Bags Ltd | Manufacturing | 2026 |
| Drus Cafe and Desserts Ltd | Hospitality | 2019 |
| DRV Asset Management Limited | Real estate | 2015 |
| Drvaja Ltd | Health & social care | 2022 |
| DRW Health Ltd | Health & social care | 2023 |
| DRY Ice Network (UK) Ltd. | Manufacturing | 1995 |
| DRY Ice Network Ltd | Extraterritorial | 2018 |
| Dryad Creative Limited | Financial services | 2019 |
| Dryad Leicester Limited | Financial services | 2018 |
| Drym Health Ltd | Health & social care | 2022 |
| Drynks LAB Ltd | Hospitality | 2021 |
| Dryv Limited | Wholesale & retail | 2025 |
| DS Bodyworks Ltd | Manufacturing | 2025 |
| DS Bookkeeping Service (Leics) Limited | Professional & scientific | 2025 |
| DS Brothers Ltd | Wholesale & retail | 2026 |
| DS Finvest Limited | Financial services | 2025 |
| DS Houses Ltd | Hospitality | 2018 |
| DS Insulation Holdings Ltd | Wholesale & retail | 2022 |
| DS Insulation Services Limited | Wholesale & retail | 2000 |
| DS Leicester Ltd | Other services | 2025 |
| DS Patel Ltd | Professional & scientific | 2022 |
| DS Plant Ltd | Extraterritorial | 2015 |
| DS Trucking Ltd | Transport & logistics | 2026 |
| DS1 Automotive Limited | Wholesale & retail | 2025 |
| DSA Regent Holdings Ltd | Financial services | 2024 |
| DSA Regent Investments Ltd | Financial services | 2024 |
| DSC Timber Solutions Limited | Manufacturing | 2025 |
| DSD Enterprises Limited | Wholesale & retail | 2013 |
| DSD Venturetech Limited | Information & communication | 2015 |
| Dsdriverservice Ltd | Transport & logistics | 2025 |
| DSF Engineering Consultancy Limited | Administrative & support | 2014 |
| DSF Holdings Group Ltd | Financial services | 2024 |
| DSF Premier Investments Ltd | Real estate | 2024 |
| Dsgn Studio UK Ltd | Professional & scientific | 2025 |
| DSH Properties Ltd | Real estate | 2017 |