| Mawby Holdings Limited | Real estate | 2007 |
| Mccannhvsolutions Limited | Energy | 2022 |
| Mcdermott Commercials (Property) Ltd | Real estate | 2016 |
| MCS Carpentry&Joinery Ltd | Construction | 2019 |
| MCS Property Developments (Staffs) Ltd | Construction | 2023 |
| MCS Roofing & Cladding Supplies Limited | Manufacturing | 2006 |
| MD Doors & Gates Limited | Manufacturing | 2025 |
| MEC Homes (Leek) Ltd | Real estate | 2024 |
| Mefa Transport Services Limited | Health & social care | 2025 |
| Mehek of Leek Ltd | Hospitality | 2019 |
| Memorialman Limited | Manufacturing | 2026 |
| Michael Sain Limited | Other services | 2011 |
| Middle Cliffe Dairies Limited | Wholesale & retail | 2012 |
| Middle Cliffe Enterprises Ltd | Financial services | 2022 |
| Middle Cliffe Properties Ltd | Real estate | 2023 |
| Mill Publishing Ltd | Information & communication | 2013 |
| Milldale Construction Limited | Construction | 2025 |
| Miller Weblift Limited | Manufacturing | 1960 |
| Miniskips Ltd | Water & waste | 2018 |
| Mint Expeditions Ltd | Administrative & support | 2015 |
| Mkds Holdings Ltd | Financial services | 2020 |
| MLC Architectural Services Limited | Professional & scientific | 2024 |
| Modular Everything Ltd. | Professional & scientific | 2020 |
| Momand Discount Store Ltd | Wholesale & retail | 2026 |
| Moorland Developments Limited | Construction | 2018 |
| Moorland Horsebox Hire Ltd | Administrative & support | 2024 |
| Moorland Imaging (Leek) Limited | Administrative & support | 2018 |
| Moorland Medical Services Limited | Real estate | 2015 |
| Moorland Veterinary Centre Limited | Professional & scientific | 2017 |
| Moorlands Computer Services Limited | Other services | 2018 |
| Moorlands Custom Cabinets Ltd | Manufacturing | 2013 |
| Moorlands DAB Ltd | Information & communication | 2021 |
| Moorlands Developments Limited | Construction | 2022 |
| Moorlands Electrical Ltd | Construction | 2006 |
| Moorlands Home Care Limited | Health & social care | 2011 |
| Moorlands HR Ltd | Administrative & support | 2020 |
| Moorlands Optical Limited | Wholesale & retail | 2026 |
| Moorlands Radio C.I.C. | Arts & recreation | 2005 |
| Moorlands Tile and Bathroom Company Ltd | Wholesale & retail | 2021 |
| Moorlands Vehicle Rentals Ltd | Administrative & support | 2017 |
| Moorlands Voluntary and Community Transport | Administrative & support | 2019 |
| Moors Tours Ltd | Transport & logistics | 2024 |
| Moreton Manor Developments Limited | Construction | 2018 |
| Moreton Manor Holdings Limited | Financial services | 2019 |
| MOT Centre ( Leek ) Limited | Wholesale & retail | 2016 |
| Mountcastle Property Limited | Real estate | 2024 |
| MQ Trading Limited | Wholesale & retail | 2013 |
| MRW Installations Ltd | Construction | 2023 |
| MSP Services (Stoke-On-Trent) Limited | Transport & logistics | 2015 |
| MT & CM Birch Ltd | Transport & logistics | 2012 |
| MTS Electrical Maintenance Ltd | Construction | 2023 |
| Mudd & Co Ltd | Extraterritorial | 2014 |
| Mus&T Ltd | Education | 2024 |
| Mustard Leek Ltd | Wholesale & retail | 2025 |
| Mxdata Limited | Information & communication | 2012 |
| My Calm Limited | Other services | 2016 |
| Myepoxy Ltd | Manufacturing | 2025 |
| N & N Plant Hire Services Limited | Construction | 2018 |
| N P O Testing Limited | Professional & scientific | 2017 |
| N.J. Docksey Limited | Transport & logistics | 2000 |
| Nana Pams Congleton Ltd | Hospitality | 2025 |
| Neon Forest Limited | Manufacturing | 2020 |
| Nest and Ivory Properties Ltd | Real estate | 2026 |
| Neural Narratives Ltd | Information & communication | 2023 |
| New Day Partners Ltd | Wholesale & retail | 2019 |
| New Street Garage (Winkhill) Limited | Wholesale & retail | 2011 |
| Nexeron Limited | Hospitality | 2026 |
| Nexus Engineering Design Solutions Ltd | Professional & scientific | 2025 |
| Ngolf Ltd | Information & communication | 2015 |
| Ninja HR Ltd | Administrative & support | 2022 |
| Niracrest Ltd | Wholesale & retail | 2026 |
| Nixon Reeves Ltd | Construction | 2005 |
| NJL Consultancy Ltd | Administrative & support | 2015 |
| NKT Ltd | Wholesale & retail | 2015 |
| NLS (Leek) Limited | Wholesale & retail | 2009 |
| NO 5 Cafe Limited | Hospitality | 2016 |
| NO DIG Hoarding & Fencing Systems Limited | Construction | 2017 |
| NO Stress Property Ltd | Construction | 2021 |
| Noman Ltd | Wholesale & retail | 2026 |
| Norman Ferns Removals Limited | Transport & logistics | 2024 |
| Norscan - HUS Limited | | 1984 |
| North Downs Dairy Co. Limited | Manufacturing | 1983 |
| North Downs International Limited | Manufacturing | 1986 |
| Northwich Hearing Centre Ltd | Wholesale & retail | 2024 |
| Nose and Paws Active Limited | Arts & recreation | 2021 |
| NOT to Late Ltd | Administrative & support | 2025 |
| NOX Star Ltd | Wholesale & retail | 2026 |
| Nrglex Limited | Professional & scientific | 2011 |
| Nutra Pulse Limited | Wholesale & retail | 2025 |
| Oakland Carpentry MC Limited | Construction | 2014 |
| Objective Training Design Ltd | Professional & scientific | 2022 |
| OHH, Fancy! Limited | Extraterritorial | 2006 |
| Openly YOU Ltd | Health & social care | 2025 |
| Orata Ltd | Information & communication | 2019 |
| Ornua UK Limited | Manufacturing | 1987 |
| OUR Belonging Ltd | Professional & scientific | 2025 |
| Outlandia Limited | Wholesale & retail | 2022 |
| Outliers Brokerage Limited | Information & communication | 2016 |
| P L Whittaker Limited | Professional & scientific | 2017 |
| P L Whittaker Taxation Limited | Professional & scientific | 2017 |