| Support Brand Ltd | Wholesale & retail | 2024 |
| Support by Strive Ltd | Hospitality | 2023 |
| Support IT 4U (Holdings) Ltd | Information & communication | 2012 |
| Support Warehouse Limited | Information & communication | 2000 |
| Supratude Limited | Information & communication | 2015 |
| Supreme Clean Family Ltd | Administrative & support | 2020 |
| Supreme Cuisine London Ltd | Hospitality | 2021 |
| Supreme Developments (Yorkshire) Ltd | Real estate | 2020 |
| Supreme Electrical Solutions Limited | Construction | 2017 |
| Supreme Fitness Coach Limited | Arts & recreation | 2025 |
| Supreme Greengrocers Limited | Wholesale & retail | 2013 |
| Supreme Heating Solutions Ltd | Construction | 2015 |
| Supreme Indulgence Ltd | Hospitality | 2019 |
| Supreme Industries Ltd | Wholesale & retail | 2017 |
| Supreme Tailoring Limited | | 1983 |
| SUR Wellness Ltd | Health & social care | 2022 |
| Sura Group Limited | Financial services | 2026 |
| Surabhi Medical Limited | Health & social care | 2024 |
| Surat Limited | Health & social care | 2010 |
| Suraya Ltd | Other services | 2023 |
| Surbiton Fitbox Ltd | Arts & recreation | 2021 |
| Sure Drainage Solutions Ltd | Water & waste | 2023 |
| Sure Property Partners Ltd | Real estate | 2024 |
| Surebuild (Garforth) Limited | Construction | 2006 |
| Surecare North Leeds Limited | Health & social care | 2016 |
| Surer Supplies Limited | Wholesale & retail | 2019 |
| Suresign Contracts Limited | Professional & scientific | 2016 |
| Surestop Limited | Manufacturing | 2006 |
| Surface Consultants Limited | Professional & scientific | 2020 |
| Surface Design Solutions Ltd | Wholesale & retail | 2022 |
| Surface Repair Leeds Ltd | Construction | 2017 |
| Surface Ventures Ltd | Other services | 2020 |
| Surfaceskins Limited | Manufacturing | 2008 |
| Surfachem Group Limited | Professional & scientific | 1996 |
| Surfachem Limited | Wholesale & retail | 1981 |
| Surge Protection Limited | Extraterritorial | 2013 |
| Surge Sportswear Trade Limited | Wholesale & retail | 2026 |
| Surged Innovations Ltd | Health & social care | 2025 |
| Surgical Innovations Group PLC | Manufacturing | 1988 |
| Surgical Innovations Limited | Manufacturing | 1992 |
| Surgical Jurisprudence Ltd | Health & social care | 2014 |
| Suri Properties Ltd | Administrative & support | 2016 |
| Surinder House Limited | Real estate | 2024 |
| Surraya Hanif Community Support CIC | Health & social care | 2023 |
| Surrey Independent Advisers Limited | Financial services | 1994 |
| Surrey Street (NO 1 Derby) Management Company Limited | Extraterritorial | 2016 |
| Sursum Advisory Limited | Professional & scientific | 2022 |
| Surveilark Technologies Ltd | Information & communication | 2023 |
| Survey Logistics Ltd | Professional & scientific | 2010 |
| Survey Roofing Group Limited | Construction | 2014 |
| Surveys Direct Yorkshire Ltd | Professional & scientific | 2026 |
| SUS Leeds Ltd | Construction | 2021 |
| Susan Baskind Limited | Health & social care | 2025 |
| Susan Johnson Limited | Extraterritorial | 2024 |
| Susmatic Ltd | Wholesale & retail | 2022 |
| Sust-Nance Ltd | Real estate | 2021 |
| Sustain CO2 Limited | Manufacturing | 2018 |
| Sustain Collaborative Limited | Professional & scientific | 2013 |
| Sustainability Leeds Ltd | Other services | 2019 |
| Sustainability Skills-Works Limited | Professional & scientific | 2017 |
| Sustainability Without Compromise Limited | Professional & scientific | 2020 |
| Sustainable Artist C.I.C. | Education | 2023 |
| Sustainable Arts in Leeds C.I.C. | Professional & scientific | 2020 |
| Sustainable Communities Alliance CIC | Wholesale & retail | 2019 |
| Sustainable Dynamics Limited | Information & communication | 2021 |
| Sustainable Energy Environmental and Educational Development Ltd | Professional & scientific | 2014 |
| Sustainable People Limited | Financial services | 2019 |
| Sustainable Water and Drainage Systems Limited | Manufacturing | 2013 |
| Sustainaboard Group Ltd | Wholesale & retail | 2024 |
| Sustainchoice Ltd | Information & communication | 2025 |
| Sustainership Ltd | Information & communication | 2026 |
| Sutcliffe Electrical Ltd | Construction | 2024 |
| Sutcliffe Joinery Ltd | Construction | 2011 |
| Sutcliffe Property Group Ltd | Real estate | 2026 |
| Sutton Communications Limited | Professional & scientific | 2018 |
| Sutton Family Holdings Ltd | Financial services | 2014 |
| Sutton PR Limited | Professional & scientific | 2006 |
| Sutton Staithe Bar Ltd | Hospitality | 2020 |
| Suttonstaithehospitality Ltd | Hospitality | 2021 |
| Suvi Sauna Ltd | Administrative & support | 2024 |
| Suvia Care Limited | Health & social care | 2009 |
| SUZ Finance Limited | Education | 2025 |
| Suzuki Garphyttan Limited | Manufacturing | 2009 |
| SV Pro Limited | Real estate | 2025 |
| Svane Properties Limited | Hospitality | 2021 |
| Svane Ventures Limited | Professional & scientific | 2017 |
| SVB Mortgages Ltd | Financial services | 2022 |
| SVOVAH48 Ltd | Transport & logistics | 2026 |
| SVR Pharma UK Limited | Wholesale & retail | 2019 |
| Svrc Limited | Health & social care | 2025 |
| Svrd Limited | Health & social care | 2021 |
| SVS Operations Ltd | Manufacturing | 2014 |
| SVT Education Ltd | Education | 2025 |
| Svype Tech Limited | Wholesale & retail | 2024 |
| SW Inspection Ltd | Professional & scientific | 2019 |
| SW Projects Consulting Ltd | Information & communication | 2019 |
| SW Retail Consultancy Limited | Professional & scientific | 2015 |
| SW Sports & Education Ltd | Other services | 2017 |
| SW Talent Solutions Ltd | Administrative & support | 2022 |
| SW Town Planning Ltd | Professional & scientific | 2020 |