| 2 Hart's Ltd | Administrative & support | 2025 |
| 2 Lena Gardens Management Company Limited | Households | 2021 |
| 2 MEN and a Van Limited | Transport & logistics | 2013 |
| 2 Mile House Ltd | Hospitality | 2021 |
| 2 Pillar Services Ltd | Construction | 2024 |
| 2 Plan Group Limited | Professional & scientific | 2006 |
| 2 Plan Limited | Administrative & support | 2008 |
| 2 Plan Wealth Management Limited | Financial services | 2006 |
| 2 West LEA Management Company Limited | Real estate | 2013 |
| 2 Westfield Terrace Management Company Limited | Professional & scientific | 2001 |
| 2 Whingate Road RTM Company Ltd | Households | 2017 |
| 20/20 Radiology Limited | Health & social care | 2011 |
| 20/20 Vision Recordings Limited | Arts & recreation | 2000 |
| 2020 Hearing Ltd | Wholesale & retail | 2014 |
| 2030DESIGNS Limited | Professional & scientific | 2023 |
| 20:20 House (Residential Management) Limited | Households | 2008 |
| 20BY10 Limited | Wholesale & retail | 2024 |
| 20FIFTY Limited | Professional & scientific | 2020 |
| 20TWENTY Property Ltd | Real estate | 2020 |
| 21 Batcliffe Drive Management Company Limited | Real estate | 2017 |
| 21 Burton Crescent Management Limited | Households | 1992 |
| 21 Degrees Digital Services Limited | Information & communication | 2023 |
| 21 Degrees Productions Limited | Information & communication | 2024 |
| 21 Degrees Weddings Ltd | Information & communication | 2019 |
| 21 Yorkshire Limited | Real estate | 2025 |
| 21/22 Park ROW Management Company Limited | Households | 2001 |
| 2124 Ltd | Professional & scientific | 2025 |
| 22 Design Services Limited | Information & communication | 2009 |
| 22 Street Lane Holdings Limited | Education | 2015 |
| 22-44 the Shambles Limited | Hospitality | 2008 |
| 22022022 Ltd | Administrative & support | 2022 |
| 22ND Century Online Services Ltd | Professional & scientific | 2023 |
| 23 Five Design Limited | Professional & scientific | 2024 |
| 23 Five Limited | Administrative & support | 2020 |
| 23 ST Mary's LLP | | 2025 |
| 23 Westgate Ltd | Hospitality | 2014 |
| 230 Harehills Avenue (Leeds) Management Limited | Households | 2022 |
| 232 Otley Road Management Company Limited | Households | 1999 |
| 235 Harrogate Road Management Company Ltd | Households | 2005 |
| 23TWELVE Limited | Manufacturing | 2024 |
| 24 24 Jewellers Ltd | Wholesale & retail | 2024 |
| 24 Access Group Ltd | Administrative & support | 2024 |
| 24 Blenheim Square Management Company Limited | Real estate | 2024 |
| 24 Seven Cloud Communications Ltd | Information & communication | 2018 |
| 24 Seven Communications (Holdings) Ltd | Information & communication | 2017 |
| 24 Seven Communications Limited | Information & communication | 2002 |
| 24 Seven Telecom Limited | Extraterritorial | 2003 |
| 24 the Best Cleaning Ltd | Administrative & support | 2022 |
| 24 TMG Ltd | Wholesale & retail | 2023 |
| 24-7 Cutz Ltd | Other services | 2024 |
| 24-7 Electrical Services Yorkshire Ltd | Administrative & support | 2017 |
| 24/7 Cleaning Ltd | Administrative & support | 2026 |
| 24/7 Health Ltd | Health & social care | 2025 |
| 24/7 RX Limited | Health & social care | 2023 |
| 24/7 Van MAN UK Ltd | Transport & logistics | 2024 |
| 2410 Trading Limited | Financial services | 2025 |
| 247 Accommodation Ltd | Hospitality | 2025 |
| 247 FTL Express Ltd | Transport & logistics | 2024 |
| 247 Logistics (Yorkshire) Ltd | Transport & logistics | 2025 |
| 247 Nutrition Limited | Manufacturing | 2024 |
| 247 UK Developments Ltd | Wholesale & retail | 2015 |
| 24SEVEN Consultancy Services Limited | Construction | 2018 |
| 24SEVEN Property Propositions Limited | Real estate | 2024 |
| 24WIN Competitions Ltd | Wholesale & retail | 2025 |
| 25 Venner Road Limited | Households | 1994 |
| 2501 Events Limited | Professional & scientific | 2024 |
| 26 Digital Ltd | Information & communication | 2026 |
| 260 Degrees West | Financial services | 2021 |
| 261 Vintage Limited | Wholesale & retail | 2026 |
| 27 Scents Limited | Wholesale & retail | 2025 |
| 271 Hair Ltd | Other services | 2014 |
| 271I Consulting Limited | Information & communication | 2016 |
| 27DST Limited | Real estate | 2025 |
| 28 Devonshire Place Freehold Limited | Real estate | 2017 |
| 28 Devonshire Place Limited | Administrative & support | 2013 |
| 28MCD Ltd | Financial services | 2024 |
| 28UTTERFLY Ltd | Wholesale & retail | 2023 |
| 2AMDESSERTS Ltd | Hospitality | 2024 |
| 2BHK High ASH Ltd | Wholesale & retail | 2025 |
| 2BHK Management Ltd | Hospitality | 2023 |
| 2BHK Properties Ltd | Real estate | 2021 |
| 2C Developments Limited | Construction | 2017 |
| 2CHIC Event Management Ltd | Administrative & support | 2025 |
| 2DIO Architecture Ltd | Professional & scientific | 2020 |
| 2DWELL Ltd | Construction | 2025 |
| 2I Global Investments Limited | Information & communication | 2018 |
| 2I Local Media Limited | Professional & scientific | 2009 |
| 2IT Learning Ltd | Information & communication | 2022 |
| 2J Nail Supply Limited | Wholesale & retail | 2020 |
| 2M Financial Group Ltd | Financial services | 2011 |
| 2M Financial Services Ltd | Financial services | 2009 |
| 2ND Academic Showroom Ltd | Wholesale & retail | 2022 |
| 2ND Time Around Leeds Ltd | Wholesale & retail | 2023 |
| 2P1 Ltd | Information & communication | 2025 |
| 2PM Financial Services Limited | Financial services | 2002 |
| 2PRU Gymnastics Club Ltd | Arts & recreation | 2023 |
| 2RUVIA Ltd | Construction | 2025 |
| 2S2N Homes Limited | Real estate | 2025 |
| 3 B'S Yorkshire Limited | Manufacturing | 2017 |
| 3 County Property Commercial Services Limited | Other services | 2018 |