| Engie Supply Holding UK Limited | Professional & scientific | 1992 |
| Engineer + Telecommunications Ltd | Construction | 2024 |
| Engineered Assistance Limited | Manufacturing | 2008 |
| Engineered Carbons Limited | Wholesale & retail | 2017 |
| Engineered for Living Holdings Ltd | Financial services | 2021 |
| Engineered for Living Ltd | Real estate | 2020 |
| Engineered Systems (Electrical) Limited | Manufacturing | 1992 |
| Engineering Building Services (Electrical) Ltd | Construction | 2016 |
| Engineering Building Services Limited | Construction | 2014 |
| Engineering Plastic Supplies Limited | Wholesale & retail | 2002 |
| Engineering Utilities Limited | Wholesale & retail | 2011 |
| Englafot Construction Limited | Construction | 1973 |
| English Drilling Equipment Company Limited | Manufacturing | 1989 |
| English Language Video Learning Ltd | Administrative & support | 2019 |
| Engsm Ltd | Professional & scientific | 2020 |
| Engweb Design Ltd | Professional & scientific | 2025 |
| Enhance Advanced Aesthetics Ltd | Other services | 2018 |
| Enhance Automation Limited | Construction | 2010 |
| Enhance Builders Ltd | Construction | 2015 |
| Enhance Primary Healthcare Limited | Health & social care | 2011 |
| Enhance Technical Consulting Ltd | Professional & scientific | 2024 |
| Enhanced Care and Support Solutions Limited | Health & social care | 2015 |
| Enhanced Vision Limited | Real estate | 2016 |
| ENHANCEDK9 Ltd | Administrative & support | 2021 |
| Enhans Limited | Professional & scientific | 2023 |
| Enigma Consultancy Ltd | Professional & scientific | 2025 |
| Enigma Digital Enterprises Ltd | Professional & scientific | 2014 |
| Enigma International Services Limited | Wholesale & retail | 2016 |
| Enigma Wealth Management Limited | Financial services | 2014 |
| Enigmex Limited | Professional & scientific | 1990 |
| Enisade Limited | Real estate | 2009 |
| Enity Hockey Limited | Wholesale & retail | 2025 |
| Enjoy Design Holdings Limited | Financial services | 2016 |
| Enjoy Design Limited | Professional & scientific | 2010 |
| Enjoy Digital Communications Limited | Information & communication | 2008 |
| Enjoy Healthcare Ltd | Health & social care | 2019 |
| Enjoy Holdings Limited | Financial services | 2020 |
| Enjoy Safety Limited | Professional & scientific | 2025 |
| ENK Pharma Ltd | Health & social care | 2019 |
| Enkay & Co Ltd | Professional & scientific | 2012 |
| Ennah's Cakes Ltd | Manufacturing | 2020 |
| Ennerdale Apartments (Leeds) Limited | Households | 1971 |
| Enniez Helping Hand Ltd | Health & social care | 2013 |
| Enquiry Solutions Ltd | Financial services | 2016 |
| Enrax Ltd | Wholesale & retail | 2022 |
| Enrgy Counselling Ltd | Health & social care | 2025 |
| Enrichd Ltd | Wholesale & retail | 2019 |
| Enrique Enterprises Ltd | Wholesale & retail | 2004 |
| ENS Organization Ltd | Construction | 2025 |
| Ensco 1227 Limited | Financial services | 2017 |
| Ensco 1327 Limited | Professional & scientific | 2019 |
| Ensco 1519 Limited | Financial services | 2023 |
| Ensco 1528 Limited | Professional & scientific | 2023 |
| Ensco 515 Limited | Professional & scientific | 2006 |
| Enseigna Education Ltd | Education | 2015 |
| Enshaa Ltd | Construction | 2021 |
| Ensign Draughting Limited | Professional & scientific | 2005 |
| Ensign Security Services Ltd | Administrative & support | 2024 |
| ENT Leeds Limited | Health & social care | 2011 |
| Entelechy Limited | Professional & scientific | 2025 |
| Enterprise 26 Ltd | Hospitality | 2025 |
| Enterprise Growth Partners Ltd | Professional & scientific | 2026 |
| Enterprise TCG Ltd | Construction | 2020 |
| Enterprise Value Partners Limited | Administrative & support | 2026 |
| Enterpriseworx IT Limited | Professional & scientific | 2020 |
| Enterprising Data Management Limited | Information & communication | 2016 |
| Enterprising Ltd | Construction | 2026 |
| Enterprising Property Management Limited | Manufacturing | 2022 |
| Entertainment One Unscripted TV UK Limited | Information & communication | 2013 |
| Entertainment Things Ltd | Administrative & support | 2024 |
| Entesis Ltd | Financial services | 2012 |
| Entheos Media Group Ltd | Information & communication | 2019 |
| Enti Solutions Ltd | Wholesale & retail | 2020 |
| Entirely People Limited | Administrative & support | 2014 |
| Entist UK Limited | Professional & scientific | 2017 |
| Entourage Ltd | Administrative & support | 2006 |
| Entp Solutions Limited | Health & social care | 2021 |
| Entrepreneurlawyer Limited | Information & communication | 2008 |
| Entropy Records Ltd | Information & communication | 2025 |
| Entrust Services Ltd | Health & social care | 2022 |
| Entry Talent Consulting Limited | Professional & scientific | 2016 |
| Entwick (Projects) Ltd | Real estate | 2022 |
| Enula Ltd | Construction | 2021 |
| Envi Architecture Limited | Extraterritorial | 2008 |
| Envi Developments Limited | Extraterritorial | 2007 |
| Envi Homes Limited | Construction | 2024 |
| Enviro Noego Ltd | Professional & scientific | 2018 |
| Enviro-Leaf Limited | Wholesale & retail | 2013 |
| Enviro-Tek International Ltd | Extraterritorial | 2021 |
| Envirojet Ltd | Water & waste | 2025 |
| Environment Protect Ltd | Extraterritorial | 2025 |
| Environmental Project Management (Contracts) Limited | Manufacturing | 2002 |
| Environmental Sustainable Solutions Ltd | Manufacturing | 1995 |
| Environments for Learning Leeds Holdco Four Limited | Financial services | 2010 |
| Environments for Learning Leeds Holdco One Limited | Financial services | 2007 |
| Environments for Learning Leeds Holdco Three Limited | Financial services | 2008 |
| Environments for Learning Leeds Holdco Two Limited | Financial services | 2008 |
| Environments for Learning Leeds PFI Four Limited | Administrative & support | 2010 |
| Environments for Learning Leeds PFI One Limited | Administrative & support | 2007 |
| Environments for Learning Leeds PFI Three Limited | Administrative & support | 2008 |