| Sansson Ltd | Professional & scientific | 2022 |
| Santalan Limited | Administrative & support | 2023 |
| Sante Solutions Limited | Administrative & support | 2006 |
| Sapphire Cars Leamington Ltd | Transport & logistics | 2026 |
| Sapphirecreationsart Ltd | Construction | 2018 |
| Sappo Labs Limited | Professional & scientific | 2019 |
| Sapwood Tree Care Ltd | Administrative & support | 2024 |
| Sara Bond Design Limited | Administrative & support | 2015 |
| Sara Bond Property Limited | Real estate | 2023 |
| Sarah Faulkner Limited | Professional & scientific | 2013 |
| Sarah Fordham Limited | Wholesale & retail | 2015 |
| Sarah Gurney Limited | Professional & scientific | 2013 |
| Sarai Khas Properties Ltd | Households | 2022 |
| Saravni Limited | Hospitality | 2013 |
| Sarh Limited | Extraterritorial | 2009 |
| Saskia Wearden Consultancy Limited | Professional & scientific | 2019 |
| Sass Carpet & Flooring Limited | Construction | 2018 |
| Satsavia Properties Limited | Real estate | 2005 |
| Saul & Co (Leamington Spa) Limited | Other services | 2018 |
| Savage Farley Designs Ltd | Professional & scientific | 2025 |
| Savages Close Residents Association Limited | Other services | 2008 |
| Sawbridge Road Management Company Limited | Households | 2022 |
| Saxomil Limited | Professional & scientific | 2017 |
| Saxon Trading Company Limited | Financial services | 2018 |
| Saxon-Nrg Limited | Wholesale & retail | 2025 |
| Sayant Limited | Extraterritorial | 2002 |
| SB Curious Collective Ltd | Professional & scientific | 2020 |
| SB Strategy Limited | Administrative & support | 2017 |
| SBE Property Holdings Limited | Real estate | 2023 |
| Sblake FS Limited | Professional & scientific | 2016 |
| SC Legal Limited | Professional & scientific | 2018 |
| Scallywags Activity Club Ltd | Health & social care | 2010 |
| Schofield Associates Limited | Health & social care | 2026 |
| School Lane Radford Management Company Limited | Households | 2017 |
| School Marking Services Ltd | Information & communication | 2025 |
| Schoolzine Ltd | Information & communication | 2016 |
| Schordan Properties Ltd | Real estate | 2026 |
| Schrover Properties Limited | Real estate | 2012 |
| Scodd Ltd | Construction | 2020 |
| Scorilo Ltd | Transport & logistics | 2023 |
| Scoss Limited | Transport & logistics | 2020 |
| Scotney Property Group Ltd | Real estate | 2025 |
| Scott J Holdings Limited | Professional & scientific | 2021 |
| Scottish Beef Association Ltd | Other services | 2010 |
| SCP Midlands Limited | Information & communication | 2013 |
| Scratch Cook Social Limited | Hospitality | 2023 |
| Scrimgeour Engineering Ltd | Professional & scientific | 2021 |
| SCT Garage Services Limited | Wholesale & retail | 2021 |
| Sctech Consulting Services Ltd | Professional & scientific | 2021 |
| Sctech Properties Services Ltd | Real estate | 2024 |
| Sculpt Academy Education Ltd | Education | 2026 |
| Sculpt SWC Ltd | Arts & recreation | 2025 |
| Scutt Creative Ltd | Information & communication | 2021 |
| SDH in the Community CIC | Other services | 2022 |
| SDS Plant Hire and Construction Ltd | Other services | 2014 |
| SDS Road Haulage Limited | Transport & logistics | 2018 |
| Seal Properties Ltd | Real estate | 2016 |
| Sean Byrne Limited | Professional & scientific | 2012 |
| Seanic Retail Software Limited | Information & communication | 2000 |
| Season & Seasons Limited | Wholesale & retail | 2016 |
| Seatlab Ticketing Ltd | Information & communication | 2022 |
| Secoac Investments Limited | Real estate | 2020 |
| Secret Code (Mode) Limited | Information & communication | 2026 |
| Secret Mode Limited | Information & communication | 2020 |
| SEE Consultancy Limited | Professional & scientific | 2020 |
| Selachii Ltd | Real estate | 2022 |
| Selekt Design Ltd | Professional & scientific | 2025 |
| Sendmake Limited | Wholesale & retail | 2022 |
| Senflower Seeds C.I.C. | Hospitality | 2025 |
| Sentinal Holdings Limited | Financial services | 2020 |
| Sentinel Global Ltd | Professional & scientific | 2025 |
| Sentio Marketing Limited | Manufacturing | 2014 |
| Sentra Property Limited | Real estate | 2023 |
| Sequimini Ltd | Manufacturing | 2023 |
| SER. Mdl/Influencer Management Ltd. | Professional & scientific | 2025 |
| Serenity Haven Support Trading AS Prosperity Housing Group/Coventry Ltd | Health & social care | 2024 |
| Serious Money Limited | Administrative & support | 1991 |
| Sero Future Limited | Professional & scientific | 2023 |
| Serving Services Ltd | Professional & scientific | 2022 |
| Setting OUT Services Ltd | Professional & scientific | 2009 |
| Seven Scents Home Ltd | Wholesale & retail | 2018 |
| Seven Stars 1 Limited | Financial services | 2024 |
| Seymour Place Associates Limited | Professional & scientific | 2020 |
| Seymours Solicitors Limited | Professional & scientific | 2015 |
| SFG Consultants Limited | Professional & scientific | 2022 |
| SFS Consulting (Leamington Spa) Limited | Professional & scientific | 2024 |
| SGA Catering Ltd | Hospitality | 2026 |
| SGG Technology Ltd | Information & communication | 2024 |
| SGH Solutions Limited | Professional & scientific | 2022 |
| SGO Consulting Ltd | Administrative & support | 2020 |
| SGP Construction Ltd | Construction | 2019 |
| SGT Project Management Services Limited | Professional & scientific | 2014 |
| Shades Snooker Club Limited | Arts & recreation | 2002 |
| Shadow Factory Limited | Professional & scientific | 2020 |
| Shaiharini Foods Ltd | Hospitality | 2022 |
| Shakari Properties Ltd | Real estate | 2022 |
| Shakespeare Carpentry Services Ltd | Manufacturing | 2021 |
| Shakespeare Door Systems Limited | Manufacturing | 2014 |
| Shakti Design Solutions Ltd | Professional & scientific | 2026 |
| Shape Your Wardrobe Limited | Professional & scientific | 2013 |