| Protégé Ltd | Education | 2024 |
| Provino Limited | Wholesale & retail | 2016 |
| Proviz (UK) Limited | Administrative & support | 2009 |
| Prudent Financial Planning Advice Limited | Financial services | 2005 |
| Psifx Ltd | Other services | 2024 |
| Pudska Homes Limited | Real estate | 2025 |
| Puffinshop Ltd | Wholesale & retail | 2025 |
| Pumpernickel Taverns Ltd | Hospitality | 2020 |
| Pure Luxuries London Ltd | Wholesale & retail | 2009 |
| Pure System Window Cleaning Ltd | Administrative & support | 2024 |
| Purely Bathrooms Limited | Wholesale & retail | 2007 |
| Purple Interiors Ltd | Administrative & support | 2001 |
| Purple Renewables Limited | Energy | 2013 |
| Purple Sand Group (Holdings) Limited | Financial services | 2024 |
| Purple Sand Group (Sales) Limited | Real estate | 2024 |
| Purple Sand Group Limited | Real estate | 2017 |
| Purple Videos Limited | Professional & scientific | 2003 |
| PYD Limited | Extraterritorial | 2011 |
| Pyes Mill Ltd | Real estate | 2021 |
| Pyramid Consulting Limited | Construction | 2019 |
| Pyrocore Systems Ltd | Water & waste | 2026 |
| Q Brew Taps Limited | Manufacturing | 2025 |
| Q.A. Audits Limited | Agriculture & fishing | 2002 |
| Q.C.S.A. Ltd. | Professional & scientific | 1999 |
| QH Deli Lancaster Limited | Hospitality | 2022 |
| QM Systems+ Limited | Administrative & support | 2014 |
| QPH Estate and Management Services Limited | Hospitality | 2023 |
| Quaeritis Group Ltd | Information & communication | 2011 |
| Quality Street Catering Ltd | Hospitality | 2026 |
| Quantfinalytics Limited | Information & communication | 2025 |
| Quantum Base Holdings PLC | Financial services | 2020 |
| Quarks to Quasars Limited | Information & communication | 2004 |
| Quarnford Estates Limited | Agriculture & fishing | 1987 |
| Quarterhouse Lancaster Limited | Hospitality | 2019 |
| Quay Concrete Limited | Construction | 2009 |
| Quay Fabrications (Lancaster) Limited | Manufacturing | 1999 |
| Quay Services Limited | Real estate | 2015 |
| Quayside at Home Ltd | Construction | 2020 |
| Quayside Computing & Design Ltd | Manufacturing | 2017 |
| Quayside Storage Limited | Administrative & support | 2025 |
| Queens Yard Management Company Ltd | Real estate | 2009 |
| Queensgate Caravan Park Ltd | Hospitality | 2012 |
| Queensway Tiles and Bathrooms Ltd | Wholesale & retail | 2023 |
| Queer by GUM CIC | Arts & recreation | 2023 |
| Queer in Lancaster CIC | Arts & recreation | 2024 |
| Quick Digits Ltd | Information & communication | 2023 |
| Quicks Property Ltd | Real estate | 2021 |
| Quilligan Parks Limited | Hospitality | 2024 |
| Quixx Convenience Ltd | Wholesale & retail | 2018 |
| Quizicle Books Limited | Information & communication | 2022 |
| R & CJ Qhse Management Services Limited | Professional & scientific | 2015 |
| R & M Wheildon Limited | Construction | 2004 |
| R & S NW Ltd | Wholesale & retail | 2025 |
| R a Hughes Ltd | Agriculture & fishing | 2010 |
| R B Askew Contracting Ltd | Agriculture & fishing | 2018 |
| R Dyson Plastering & Tiling Ltd | Construction | 2019 |
| R E Buildings Limited | Construction | 1993 |
| R E C Services Limited | Construction | 2018 |
| R F Towers Ltd | Agriculture & fishing | 2017 |
| R G Bassett & Sons Limited | Transport & logistics | 1988 |
| R H & C Ayrton Limited | Agriculture & fishing | 2012 |
| R JOB Network Ltd | Information & communication | 2009 |
| R Pryce Electrical Limited | Construction | 2023 |
| R&M Healthtech Limited | Professional & scientific | 2020 |
| R&R Films Limited | Information & communication | 2015 |
| R. E. Salt & Co Limited | Construction | 2010 |
| R. J. Mason Ltd | Agriculture & fishing | 2014 |
| R.K. GAS Services Limited | Construction | 2006 |
| R.Taylor & Sons (Scrap) Limited | | 1962 |
| Rabg Academy Ltd | Education | 2017 |
| Rabutso Limited | Information & communication | 2014 |
| Rachel Hearne Ltd | Manufacturing | 2021 |
| Radia NW Limited | Health & social care | 2016 |
| Raefilm Limited | Information & communication | 2022 |
| Ralymi Ltd | Professional & scientific | 2025 |
| Randall Consultants (Lancaster) Limited | Professional & scientific | 2025 |
| Randall Millican SE Limited | Professional & scientific | 2025 |
| Rapture Theatre Arts Ltd | Arts & recreation | 2021 |
| Raven Aviation Ltd | Transport & logistics | 2022 |
| Rawsthorne and Eastham Ltd | Financial services | 2021 |
| RAY Metcalfe Limited | Construction | 2006 |
| Rays Court Management Company Limited | Households | 2013 |
| Razzle Dazzle Limited | Wholesale & retail | 2018 |
| RB Highfield Limited | Information & communication | 2023 |
| RB Highfield Properties Limited | Real estate | 2025 |
| RBS Hospitality Limited | Real estate | 2018 |
| RCP Plastering Contractors Limited | Construction | 2019 |
| RD Joinery North West Ltd | Construction | 2024 |
| RDA Restaurants Limited | Hospitality | 2000 |
| Re:Set Ltd | Health & social care | 2018 |
| Re:Set Recovery Studios Ltd | Administrative & support | 2023 |
| Read Properties Ltd | Real estate | 2021 |
| Ready AIM Succeed Coaching Ltd | Professional & scientific | 2024 |
| Real Agent Group Limited | Other services | 2017 |
| Real Lives Possible Worlds Ltd | Education | 2019 |
| Really Giant Posters Ltd. | Wholesale & retail | 2011 |
| Rebecca Garrett Holdings Limited | Other services | 2014 |
| Recircled Resources Ltd | Water & waste | 2016 |
| Rectory Farm Yard Owners Limited | Administrative & support | 1999 |
| Red Door Escapes Limited | Hospitality | 2021 |