| Oneness Emporium Limited | Wholesale & retail | 2025 |
| Onyourtiptoes Limited | Professional & scientific | 2025 |
| Oopstay Lancaster Ltd | Manufacturing | 2026 |
| Open Analytics Ltd | Information & communication | 2018 |
| Ophion Ltd | Information & communication | 2010 |
| Optimal Logistics Limited | Professional & scientific | 2010 |
| Optomack Ltd | Health & social care | 2012 |
| Orange IVY Photography Limited | Professional & scientific | 2023 |
| Orbital Light Optics Ltd | Professional & scientific | 2023 |
| Orcaber Camping Austwick Ltd | Hospitality | 2023 |
| Orcaber Camping Ltd. | Arts & recreation | 2019 |
| Orchard Field Bentham Limited | Real estate | 2009 |
| Orchard Training and Consultancy Ltd | Professional & scientific | 2021 |
| Organise ME Lancashire Limited | Administrative & support | 2022 |
| Organised Technology Ltd. | Manufacturing | 1998 |
| Ormrods Continuing Healthcare Limited | Health & social care | 2021 |
| Ormside Mill Residential Centre Limited | Arts & recreation | 1998 |
| Orti Lancaster Ltd | Hospitality | 2017 |
| Osbaldeston Hall Farm Riding Centre Limited | Arts & recreation | 1986 |
| OST Limited | Wholesale & retail | 2023 |
| OST Outlet Ltd | Wholesale & retail | 2025 |
| Osteorehab Clinics Ltd | Health & social care | 2026 |
| OSW Solutions Ltd | Administrative & support | 2025 |
| Otter House Productions Ltd | Information & communication | 2022 |
| OUR Shop 3 Limited | Hospitality | 2018 |
| Ours Property Limited | Real estate | 2026 |
| Outdoor Adventurer Limited | Extraterritorial | 2011 |
| Overseas Education Trust Limited | Education | 2010 |
| Oxcliffe Limited | Information & communication | 2012 |
| Oxica Limited | Information & communication | 2004 |
| Oxyamco (UK) Limited | Other services | 2020 |
| Oxygen Creative Limited | Professional & scientific | 2020 |
| P & Y Well Services Limited | Mining & quarrying | 1990 |
| P Culligan Limited | Real estate | 2023 |
| P G Studio Limited | Professional & scientific | 2020 |
| P&Pc Surveyors Ltd | Real estate | 2008 |
| P.I. London Limited | Professional & scientific | 2016 |
| P6 Spice & Co Ltd | Hospitality | 2025 |
| Pacific Crest Ltd | Professional & scientific | 2026 |
| Packaging Services Europe Limited | Administrative & support | 2016 |
| Padem Ltd | Wholesale & retail | 2015 |
| Padgett Properties Caton Limited | Real estate | 2025 |
| Pagm Limited | Health & social care | 2022 |
| Paley's Wood Limited | Real estate | 2019 |
| Palm Shehryar Limited | Real estate | 2013 |
| Palm Tree Partnerships Ltd | Administrative & support | 2023 |
| Panther Payroll Limited | Professional & scientific | 2015 |
| Papa Juliet Ltd | Professional & scientific | 2023 |
| Parallel Movie Ltd | Information & communication | 2023 |
| Paramount Prestige Limited | Wholesale & retail | 2020 |
| Parinama Ltd | Professional & scientific | 2023 |
| Park Hotel Lancaster Ltd | Hospitality | 2022 |
| Park Mews (Hornby) Limited | Households | 1989 |
| Park Social Work Solutions Limited | Health & social care | 2015 |
| Parker Property Investments Limited | Administrative & support | 1998 |
| Parkeriot Limited | Information & communication | 2025 |
| Parkhouse Court (Barrow) Management Company Limited | Real estate | 2007 |
| Parkin Woods Services Limited | Construction | 2001 |
| Parkinson Properties (Lancaster) Limited | Real estate | 2000 |
| Parklands (Caton) Management Company Limited | Households | 2023 |
| Parkway Insurance Ltd | Financial services | 1985 |
| Parton & Co Ltd | Financial services | 2021 |
| Partyupgg Ltd | Professional & scientific | 2025 |
| Pascals PUB Limited | Hospitality | 2025 |
| Pasha NW Ltd | Wholesale & retail | 2024 |
| Patisserie SAM Ltd | Manufacturing | 2023 |
| Patterned Earth Landscape and Garden Design Limited | Administrative & support | 2025 |
| Paul Clegg & Company Limited | Extraterritorial | 2010 |
| Paul Pedals Limited | Wholesale & retail | 2025 |
| Pause United Ltd | Education | 2024 |
| PB Architecture Limited | Professional & scientific | 2020 |
| PBS Financial Solutions Ltd | Financial services | 2007 |
| PD Lawyers Limited | Professional & scientific | 2009 |
| Peak Brand Management Ltd | Professional & scientific | 2024 |
| Peak Performance Rooftop Maintenance Ltd | Construction | 2026 |
| Pearl Tea & Arts Limited | Wholesale & retail | 2019 |
| Pearson Joinery Limited | Construction | 2012 |
| Pegasus Financial Planning Limited | Professional & scientific | 2020 |
| Pegasus Portfolio Planning LLP | | 2005 |
| Pegasus Window Cleaning Ltd | Administrative & support | 2011 |
| Pellet Trials UK Ltd | Manufacturing | 2019 |
| Pelumbra Ltd | Professional & scientific | 2010 |
| Pemberton Properties Lytham Limited | Real estate | 2022 |
| Penhale Court Limited | Real estate | 2004 |
| Peninsula Contract Furnishings Ltd | Other services | 2018 |
| Peninsula Group Ltd | Extraterritorial | 2019 |
| Pennine Court Land Management Company Limited | Extraterritorial | 2006 |
| Pennington Court RTM Company Limited | Households | 2021 |
| Penny Mini Market Ltd | Wholesale & retail | 2026 |
| Pensemore Ltd | Financial services | 2008 |
| Penta Cleaning and Moving Solutions Ltd | Construction | 2025 |
| People Development Matters Group Ltd | Professional & scientific | 2023 |
| Peoplepraxis Ltd | Professional & scientific | 2025 |
| Peppered Palette Ltd | Manufacturing | 2022 |
| Perfect Properties Group Ltd | Real estate | 2024 |
| Perilicious Lancs Limited | Hospitality | 2024 |
| Person 1ST Childcare Limited | Health & social care | 2011 |
| Petre Management Ltd | Extraterritorial | 2022 |
| Pgbws Limited | Information & communication | 2023 |
| PGK Engineering Limited | Professional & scientific | 2015 |