| Rockwood Tile and Flooring Limited | Construction | 1984 |
| Roebridge Financial Management Limited | Financial services | 2002 |
| Roger Eaves & Son.Limited | Construction | 1946 |
| Roger Eaves Building Limited | Construction | 1953 |
| Roland Whatmore Limited | Construction | 1959 |
| Ron's Furniture Factory Limited | Wholesale & retail | 2018 |
| Roots Hindley Limited | Other services | 2002 |
| Rosehill Printers & Converters Limited | Manufacturing | 1979 |
| Rosney Joinery Contractors Ltd | Construction | 2005 |
| Rossall Window Company Ltd. | Construction | 1995 |
| Rosy Apple Childcare Limited | Administrative & support | 2003 |
| Rota ROD Limited | Manufacturing | 2002 |
| Rothwell Audio Products Limited | Manufacturing | 2003 |
| Rowan Veterinary Centre Limited | Professional & scientific | 2004 |
| ROY Turnbull (Fasteners) Limited | Wholesale & retail | 1987 |
| Royal Oak Landscape Design Limited | Administrative & support | 2004 |
| Royle Estates (Lancaster) Limited | Real estate | 2001 |
| Royton Dervent Ltd | Wholesale & retail | 2025 |
| RRG Group Limited | Wholesale & retail | 1972 |
| RS Infotech Ltd | Information & communication | 1997 |
| Rssei Ltd | Manufacturing | 2007 |
| Rufford Lathom Ltd | Wholesale & retail | 2025 |
| Rumbletums Ltd | Hospitality | 2003 |
| Russell Cargo Services Ltd. | Transport & logistics | 1993 |
| Russell Commercials Limited | Wholesale & retail | 2006 |
| Ruttle Heavy Haulage Limited | Administrative & support | 2007 |
| Ruttle Plant Holdings Limited | Professional & scientific | 1977 |
| Ruweigho Ltd | Other services | 2025 |
| RW & M Clark Ltd | Real estate | 1978 |
| RWH Management Ltd | Hospitality | 2021 |
| Ryan Anthony Services Limited | Professional & scientific | 1998 |
| Ryan Dental Services Ltd | Health & social care | 2007 |
| Ryans Business Advisors Limited | Professional & scientific | 2006 |
| Ryans Financial Management Limited | Financial services | 2005 |
| Ryde Optical Ltd | Wholesale & retail | 2017 |
| Ryder Properties (UK) Limited | Real estate | 2007 |
| Ryecourt Limited | Administrative & support | 2000 |
| S & K Property Management Limited | Transport & logistics | 2007 |
| S & R NU Look Hair Salon Limited | Other services | 2003 |
| S & S Supplies Limited | Extraterritorial | 1984 |
| S a Clough (Sewing M/Cs.) Bacup Limited | Wholesale & retail | 2002 |
| S a Marland Flooring Contractors Limited | Administrative & support | 2007 |
| S C D M Limited | Real estate | 2000 |
| S G H a Limited | Professional & scientific | 2005 |
| S G Silicone Products Limited | Manufacturing | 2002 |
| S J Nicholls Golf Limited | Wholesale & retail | 2003 |
| S K Electronics Limited | Administrative & support | 2001 |
| S Kirk Engineering Services Ltd | Manufacturing | 2006 |
| S P F Media Limited | Professional & scientific | 2006 |
| S R & R J Brown Limited | Agriculture & fishing | 2004 |
| S S Gilman & SON Limited | Wholesale & retail | 1965 |
| S T R Properties Limited | Real estate | 2003 |
| S W Allen Optical Limited | Wholesale & retail | 2004 |
| S. & P. Lomas Limited | Wholesale & retail | 2003 |
| S. C. Group Limited | Professional & scientific | 1987 |
| S. Schofield Steel Fabrications Limited | Manufacturing | 2005 |
| S.B. Electrical (Leigh) Limited | Manufacturing | 2008 |
| S1 Fire Ltd | Manufacturing | 2022 |
| SA Kitchens & Bedrooms Limited | Wholesale & retail | 2004 |
| SA Kitchens Limited | Professional & scientific | 2004 |
| SA Medical Services Ltd | Health & social care | 2019 |
| Safety Workwear Ltd | Wholesale & retail | 2008 |
| Safran Nacelles Limited | Manufacturing | 1989 |
| Sagon Finance Limited | Professional & scientific | 2005 |
| Sahara Project (Preston) Limited | Health & social care | 1994 |
| Saints & Sinners Limited | Wholesale & retail | 2007 |
| Saka Tattoo Ltd | Other services | 2025 |
| Salemart Limited | Professional & scientific | 1999 |
| Sales Management Consultancy Ltd | Professional & scientific | 2024 |
| Salisburys GAS & Electrical Ltd | Wholesale & retail | 2006 |
| Sally Wilks Limited | Arts & recreation | 2003 |
| Samsorros Ltd | Hospitality | 2002 |
| Sana Trading Limited | Wholesale & retail | 1998 |
| Sandfield Park Limited | Real estate | 2001 |
| Sands Care Holdings Limited | Financial services | 2008 |
| Sands Care Morecambe Limited | Health & social care | 1995 |
| Sanvie UK Ltd | Wholesale & retail | 2026 |
| Sarah Louise Limited | Manufacturing | 1974 |
| Sativa (U.K.) Limited | Manufacturing | 2004 |
| Saunders & Taylor (Manchester) Ltd | Construction | 1998 |
| Savensail Limited | Administrative & support | 2001 |
| Savoy Sports and Leisure Limited | Administrative & support | 1982 |
| Sbaikawrs Limited | Wholesale & retail | 2023 |
| Scaitcliffe Community Centre | Education | 2004 |
| Scan CI Limited | Information & communication | 2006 |
| Scanimage Limited | Administrative & support | 1998 |
| SCENT4YOU Ltd | Wholesale & retail | 2019 |
| SCG Joinery Ltd | Construction | 2025 |
| Scholastic Souvenir Company Limited | Professional & scientific | 1928 |
| Scotch Garage Limited | Wholesale & retail | 2007 |
| Screenline (UK) Limited | Administrative & support | 1997 |
| Scrutiny (Outsourcing) Limited | Professional & scientific | 2001 |
| SDL Drywall and Plastering Limited | Construction | 2024 |
| Sdlc Testing Solutions Ltd | Information & communication | 2005 |
| Search Engine Solutions Group Limited | Financial services | 2025 |
| Seasondune Limited | Real estate | 1985 |
| Sector Software Limited | Information & communication | 1993 |
| Sekim Holdings Limited | Professional & scientific | 2001 |
| Selby Marketing Services Ltd. | Professional & scientific | 2000 |
| Select Interior Shutters Limited | Professional & scientific | 2007 |