| Sparkleclean Experts Ltd | Administrative & support | 2025 |
| Sparkodic Ltd | Wholesale & retail | 2024 |
| Spartan Nava Ltd | Wholesale & retail | 2025 |
| Spatj Limited | Information & communication | 2024 |
| Speakera Access Limited | Information & communication | 2026 |
| Spearhead Dynamics Ltd | Education | 2025 |
| Spec Health and Social Care Limited | Health & social care | 2024 |
| Specdoor Ltd | Information & communication | 2025 |
| Specialist Laser Care Limited | Professional & scientific | 2018 |
| Specialist Laser Logistics Limited | Professional & scientific | 2018 |
| Specialist Recycling Ltd | Water & waste | 2025 |
| Specmora Listing Systems Ltd | Information & communication | 2026 |
| Spectra Acquisition Ltd | Information & communication | 2025 |
| Spectrum International Trading Co., Ltd | Wholesale & retail | 2024 |
| Speech Inspired Ltd | Administrative & support | 2018 |
| Speed Formula Media Ltd | Information & communication | 2026 |
| Speirah Holdings Ltd | Information & communication | 2025 |
| Spellman Richard Group Limited | Wholesale & retail | 2026 |
| Sperce Thareston Ltd | Wholesale & retail | 2025 |
| Sphere Construction (Southwest) Limited | Construction | 2020 |
| Sphinx Industry Limited | Manufacturing | 2024 |
| SPI Trade Ltd | Financial services | 2025 |
| Spice Beauty Ltd | Wholesale & retail | 2025 |
| Spick-N-Span Cleaning (UK) Ltd | Other services | 2012 |
| Spicy Holdings Ltd | Professional & scientific | 2022 |
| Spidershare Company Ltd | Extraterritorial | 2010 |
| Spin & Sound Ltd | Wholesale & retail | 2025 |
| Spinedeck Limited | Wholesale & retail | 2020 |
| Spinghxui Ltd | Wholesale & retail | 2025 |
| Spirit and Salt Ltd | Wholesale & retail | 2026 |
| Spirit Champion Ltd | Wholesale & retail | 2022 |
| Spirits Logistics Ltd | Wholesale & retail | 2018 |
| Splash Babies Limited | Education | 2012 |
| Splendid Oriental Co., Ltd | Wholesale & retail | 2025 |
| Split the Juice Ltd | Information & communication | 2025 |
| SPO Bearing Co., Ltd. | Administrative & support | 2020 |
| Sporecraft Ltd | Professional & scientific | 2026 |
| Spotless Pro Cleaning Limited | Administrative & support | 2025 |
| Spring Scenery Ltd | Wholesale & retail | 2025 |
| Springtrade Ltd | Other services | 2009 |
| Springwell Tapestry Ltd | Wholesale & retail | 2025 |
| Sprint Asset Management Ltd | Administrative & support | 2018 |
| Sprint Creative Studios Ltd | Professional & scientific | 2026 |
| Sproutdesk Ltd | Professional & scientific | 2018 |
| Sproutgrowth Ltd | Wholesale & retail | 2024 |
| SPS Wholesales Ltd | Wholesale & retail | 2022 |
| Sqihlngiuang Ltd | Wholesale & retail | 2025 |
| Sqish & Sqosh Ltd | Education | 2026 |
| Squad Jujur Ltd | Arts & recreation | 2025 |
| Square Solutions Team Ltd | Wholesale & retail | 2021 |
| Squareone Glass Limited | Construction | 2025 |
| Squiggly FOX Ltd | Wholesale & retail | 2026 |
| Squishy Community Ltd | Manufacturing | 2025 |
| SR Cinematography Ltd | Information & communication | 2018 |
| SR Global Sports Ltd | Arts & recreation | 2025 |
| Sremed Business Limited | Wholesale & retail | 2025 |
| Srlines Software House Ltd | Other services | 2025 |
| SS & TKS LLP | | 2024 |
| SS Advocacy and Advisory Services Ltd | Administrative & support | 2023 |
| SS Beauty Ltd | Information & communication | 2024 |
| SSC Production Ltd | Information & communication | 2023 |
| Ssccsy Ltd | Manufacturing | 2025 |
| SSL Creation Ltd | Manufacturing | 2025 |
| SSS Engineering Services Ltd | Manufacturing | 2013 |
| ST Motor Technology Limited | Extraterritorial | 2015 |
| Staff Trade Solutions Ltd | Administrative & support | 2025 |
| Staffnet Training and Recruitment Limited | Administrative & support | 2012 |
| Stage One AV Limited | Arts & recreation | 2016 |
| Stageware Ltd | Administrative & support | 2025 |
| Stake Logistix Solution Ltd | Transport & logistics | 2025 |
| Stalwart Holdings UK LLP | | 2020 |
| Standard Heritage Investment Management Holding Group Ltd | Professional & scientific | 2025 |
| Stanford Harrington Group Limited | Professional & scientific | 2021 |
| Stanobas Global Ventures Ltd | Wholesale & retail | 2023 |
| Stanolind Gumble Ltd | Wholesale & retail | 2025 |
| Stanton Stone Limited | Professional & scientific | 2012 |
| Stanton Systems Ltd | Information & communication | 2025 |
| Star Assets Limited | Real estate | 2023 |
| Star Broadcast Entertainment Ltd | Wholesale & retail | 2026 |
| Star Garden Media Ltd | Other services | 2019 |
| Star Nexus Limited | Wholesale & retail | 2025 |
| Star Safety Glazing Limited | Construction | 2017 |
| Star Sight Systems Limited | Professional & scientific | 2026 |
| Starbow Global Ltd | Wholesale & retail | 2025 |
| Starconn Fluid Control Engineering Co., Ltd. | Extraterritorial | 2014 |
| Starcore Tech Ltd | Wholesale & retail | 2026 |
| Starcrown Trading Co., Ltd | Administrative & support | 2023 |
| Stardrive Limited | Wholesale & retail | 2025 |
| Starglow Group Ltd | Wholesale & retail | 2025 |
| Stargold International UK Limited | Wholesale & retail | 2022 |
| Stark New Materials Limited | Manufacturing | 2025 |
| Starlet Maty Ltd | Professional & scientific | 2009 |
| Starlight Bazaar Co., Ltd | Wholesale & retail | 2025 |
| Starlight Culture Ltd | Wholesale & retail | 2026 |
| Starlin Homes Limited | Health & social care | 2025 |
| Starling Realty Ltd | Real estate | 2025 |
| Starlio.Tech Ltd | Information & communication | 2024 |
| Starpulse Live Ltd | Wholesale & retail | 2025 |
| Starrism Trading Ltd | Wholesale & retail | 2026 |
| Stars Shining Co., Ltd | Wholesale & retail | 2025 |