| Sferra Fine Linens UK Limited | Wholesale & retail | 2018 |
| SG Exchange Ltd | Wholesale & retail | 2021 |
| SG Visuals Limited | Other services | 2010 |
| SG Westerham Ltd | Hospitality | 2022 |
| SGI Hampton Wick Development Management Company Limited | Households | 2020 |
| SGO Limited | Professional & scientific | 2000 |
| SGO Music Management Limited | Arts & recreation | 2000 |
| SGO Music Publishing Limited | Information & communication | 1990 |
| SGR Films Limited | Professional & scientific | 2023 |
| SGT Group Ltd | Extraterritorial | 2025 |
| SH Project Management Ltd | Other services | 2014 |
| Shabak Land Limited | Real estate | 2025 |
| Shadow Fire Ltd | Construction | 2019 |
| Shah G Ltd | Hospitality | 2022 |
| Shajhan Ltd | Hospitality | 2015 |
| Shaksstaxofwax Ltd | Wholesale & retail | 2018 |
| Shamdasani Change Ltd | Information & communication | 2026 |
| Shana Enterprises Limited | Hospitality | 2015 |
| Shane Hutchinson Consultancy Ltd | Professional & scientific | 2026 |
| Shane Hutchinson Ltd | Professional & scientific | 2024 |
| Shared Living Ltd | Real estate | 2024 |
| Sharkie’S Pizza Ltd | Hospitality | 2025 |
| Sharon Rice-Oxley Limited | Professional & scientific | 2012 |
| Sharqiya Limited | Information & communication | 2007 |
| Sharqy Limited | Information & communication | 2014 |
| Shaysi Properties Limited | Real estate | 2022 |
| Sheen Uncovered Limited | Wholesale & retail | 1999 |
| Shelbys Traders Limited | Transport & logistics | 2024 |
| Shella Lusarito Ltd | Health & social care | 2024 |
| Shellscrape Games Ltd | Information & communication | 2025 |
| Shelter International Invest Ltd | Administrative & support | 2017 |
| Shelving Plus Limited | Wholesale & retail | 2011 |
| Shenzhen Kangaroo Garments Co., Ltd. | Extraterritorial | 2008 |
| Shepperton Signs Middx Limited | Administrative & support | 2002 |
| Sheridan Law LLP | | 2011 |
| Shiftzz Limited | Information & communication | 2022 |
| Shiraz Persia Ltd | Hospitality | 2024 |
| Shiraz Rentals Ltd | Real estate | 2019 |
| Shire Place Residents Company Limited | Households | 1995 |
| Shirley Hyrst Residents' Association Limited | Households | 1981 |
| Shiv Sans Limited | Administrative & support | 2004 |
| SHL Developments Ltd | Real estate | 2023 |
| SHN Care Ltd | Health & social care | 2012 |
| Shoeshow Limited | Wholesale & retail | 2025 |
| Shopping Mary Limited | Manufacturing | 2003 |
| Shopping Monkeys Ltd | Wholesale & retail | 2025 |
| Showprint Graphics Limited | Professional & scientific | 1994 |
| Shrivedhan Ltd | Information & communication | 2023 |
| Shrub and Stone Limited | Administrative & support | 2018 |
| Shukrana Foods Limited | Wholesale & retail | 2026 |
| Shumen Ltd | Construction | 2013 |
| Shuriana Ltd | Professional & scientific | 2017 |
| Shutter 24 Ltd | Construction | 2022 |
| Shutter Design Limited | Construction | 2016 |
| Shwinq Ltd | Professional & scientific | 2021 |
| Sialthan Ltd | Health & social care | 2021 |
| Sian Almond Cooks Ltd | Education | 2026 |
| Sibu Consultancy Limited | Professional & scientific | 2022 |
| Sienna INK Ltd | Information & communication | 2024 |
| Sierra Echo Projects Limited | Professional & scientific | 2018 |
| Sigma Business Intelligence Services (PVT) Ltd | Information & communication | 2014 |
| Sigma Sports Holdings Limited | Financial services | 2018 |
| Sigma Sports Limited | Wholesale & retail | 2003 |
| Sign & Lighting Innovations Ltd | Manufacturing | 2006 |
| Sign Savvy Limited | Professional & scientific | 2014 |
| Sign-Tec Supplies Limited | Manufacturing | 2023 |
| Signature Lettings and Investments Ltd | Real estate | 2019 |
| Signet Seal Ltd | Professional & scientific | 2025 |
| Significant Limited | Administrative & support | 1998 |
| Silklis Limited | Wholesale & retail | 2012 |
| Silva Express Ltd | Wholesale & retail | 2022 |
| Silver Harvest Limited | Real estate | 2020 |
| Silver Throne Limited | Hospitality | 2010 |
| Silvercrest House Management Limited | Households | 1988 |
| SIM Textile Ltd | Wholesale & retail | 2021 |
| Siman Systems Limited | Information & communication | 2019 |
| Simbiosis BI Limited | Information & communication | 2012 |
| Simmonds Maintenance Ltd | Construction | 2026 |
| Simmons Taylor Hall Topco Limited | Financial services | 2023 |
| Simon Bain Building Services Limited | Construction | 2002 |
| Simon Says Events Limited | Information & communication | 2021 |
| Simple 2023 Ltd | Hospitality | 2023 |
| Simple Parts Co., Ltd | Wholesale & retail | 2019 |
| Simple Pleasures Limited | Hospitality | 2023 |
| Simply Secure Services Limited | Financial services | 1992 |
| Simply Technical Limited | Construction | 2022 |
| SIMS4TRAINING Ltd | Professional & scientific | 2017 |
| Simulus Education Services Limited | Other services | 1998 |
| Simulus Properties Ltd | Real estate | 2020 |
| SIN Fitness Academy Limited | Other services | 2021 |
| Singing in the Rain CIC | Health & social care | 2023 |
| Sirius Consulting Limited | Professional & scientific | 2025 |
| Sirus Wallcovering Limited | Construction | 2020 |
| Sisu and Glow Ltd | Other services | 2019 |
| SIX3NINE Ltd | Professional & scientific | 2025 |
| SJ Retail Limited | Wholesale & retail | 2016 |
| SJC Haus Ltd | Real estate | 2025 |
| SJM Engineering Consulting Services Limited | Other services | 2010 |
| SJW IT Solutions Limited | Information & communication | 2007 |
| SK Greenfield Solutions Ltd | Information & communication | 2015 |