| Declutterwise Ltd | Public administration | 2025 |
| Decorque Limited | Wholesale & retail | 2012 |
| Deep Jyoti Properties Ltd | Real estate | 2026 |
| Defined Aesthetics Oxford Limited | Other services | 2025 |
| Degu IO Ltd | Information & communication | 2015 |
| Dehalvi Investments LLP | | 2021 |
| Delpol Ltd | Construction | 2016 |
| Delta 3 Limited | Construction | 2007 |
| Delta Alpha PSI Services Limited | Professional & scientific | 2015 |
| Dene Baldwin Associates Limited | Professional & scientific | 2014 |
| Dene House Limited | Households | 2006 |
| Detail Drive Ltd | Professional & scientific | 2025 |
| Development Smart Properties Ltd | Real estate | 2024 |
| DFG Design Ltd | Construction | 2021 |
| DGM Electrical (Oxford) Limited | Construction | 2016 |
| Diamond Physiotherapy Ltd | Health & social care | 2026 |
| Digital Vision Advisors Limited | Professional & scientific | 2019 |
| Digital Workflow Limited | Other services | 2019 |
| Dispergo Vaping Ltd | Wholesale & retail | 2019 |
| Diverse Direct Ltd | Wholesale & retail | 2012 |
| Diverse Direct Solutions Limited | Information & communication | 2018 |
| Divine Beauty Parlour Ltd | Wholesale & retail | 2024 |
| DJL (Coventry) Limited | Real estate | 2015 |
| DK Veterinary Services Ltd | Professional & scientific | 2025 |
| DKM Builders (Oxford) Ltd | Construction | 2021 |
| DL UK Property Ltd | Real estate | 2022 |
| Doda Nest Ltd | Households | 2026 |
| Dododo Ltd | Manufacturing | 2025 |
| Dorchester Court (Summertown) Limited | Households | 1995 |
| Dorchester Court Management (Headington) Company Limited | Households | 1996 |
| Dowleys Business Enterprises Limited | Wholesale & retail | 2009 |
| DPG Carpentry Limited | Construction | 2019 |
| DR Allyson Parry Limited | Health & social care | 2023 |
| DR. Peter Lawrence Limited | Financial services | 2006 |
| Dreamforge-Entertainment Ltd | Information & communication | 2024 |
| Dreaming Spires Photography Ltd | Professional & scientific | 2023 |
| Drop Zone Delivery Ltd | Transport & logistics | 2026 |
| Dukes Court (9 Shipton Road) Management Company Limited | Households | 2015 |
| Duofarm Limited | Extraterritorial | 1979 |
| Dynamix Technology Limited | Professional & scientific | 1993 |
| Dyne Testing Limited | Administrative & support | 2013 |
| Dynovia Ltd | Professional & scientific | 2024 |
| E. R. P Electrical Ltd | Construction | 2025 |
| E.A.Sowter Limited | Manufacturing | 1935 |
| East Street Fritwell Management Company Limited | Households | 2006 |
| Eastfield Place Management Limited | Households | 2004 |
| Eclectic Creative Interiors Limited | Professional & scientific | 2024 |
| Ecomora Ltd | Wholesale & retail | 2024 |
| Edchauffeurs Ltd | Transport & logistics | 2021 |
| Edss Property Ltd | Real estate | 2021 |
| Edss Rural Ltd | Real estate | 2018 |
| Edward RM Ltd | Administrative & support | 2023 |
| Egal Property Group Limited | Real estate | 2024 |
| EGO Cargo Care Ltd | Construction | 2020 |
| EGW Bloodstock Ltd | Agriculture & fishing | 2022 |
| EGW Translations Ltd | Professional & scientific | 2021 |
| Eids Productions Ltd | Information & communication | 2024 |
| Eleanor Mace Audiology Ltd | Health & social care | 2024 |
| Electrogenic Ltd. | Wholesale & retail | 2018 |
| Elevate Travel Ltd | Administrative & support | 2025 |
| Elida Ndregjoni Ltd | Health & social care | 2024 |
| Elite Bodies Ltd | Arts & recreation | 2025 |
| Elite Case Management Ltd | Professional & scientific | 2025 |
| Elitebnb Ltd | Real estate | 2024 |
| Ellard Outloud Limited | Information & communication | 2018 |
| Elmelo Limited | Information & communication | 2016 |
| Elmerston Limited | Construction | 2013 |
| Emad Salehi Ltd | Wholesale & retail | 2021 |
| Emergency Nutrition Network | Information & communication | 2003 |
| Empire Barber 2 Limited | Other services | 2024 |
| Empire City Construction Limited | Construction | 2020 |
| Enaibl Ltd | Health & social care | 2023 |
| Enwild Ventures Ltd | Construction | 2025 |
| EP Property Developments Ltd | Construction | 2023 |
| Ep&Ic Limited | Arts & recreation | 2017 |
| EP8 Ltd | Construction | 2026 |
| Epic Laser and Beauty Ltd | Other services | 2025 |
| Eran Ltd | Real estate | 2026 |
| Erebagen Ltd | Professional & scientific | 2020 |
| ERP Magic Limited | Other services | 2012 |
| ERS Consultants Ltd | Professional & scientific | 2006 |
| Eskf Land Ltd | Real estate | 2025 |
| Esnt Holdings (NO.1) Limited | Professional & scientific | 1997 |
| Esnt International Limited | Professional & scientific | 1985 |
| ESP Photo Ltd | Manufacturing | 2024 |
| Esquire Estates London Ltd | Real estate | 2024 |
| Essentra (Northampton) Ltd. | Extraterritorial | 1995 |
| Essentra Components Limited | Manufacturing | 1955 |
| Essentra Finance Limited | Administrative & support | 2005 |
| Essentra International Limited | Professional & scientific | 1974 |
| Essentra Overseas Limited | Professional & scientific | 2007 |
| Essentra Pension Trustees Limited | Professional & scientific | 2005 |
| Essentra PLC | Professional & scientific | 2005 |
| Esther House (Kidlington) Freehold Company Limited | Households | 2025 |
| Ethica Luma Ltd | Information & communication | 2025 |
| Euro Impex International Limited | Wholesale & retail | 2020 |
| European Industrial Resource Supplier Ltd | Wholesale & retail | 2025 |
| Evenlode Electrical Ltd | Construction | 2021 |
| Event Catering by Green's Limited | Hospitality | 2013 |
| Evie Charging Limited | Construction | 2021 |