| Snow Manor Ltd | Wholesale & retail | 2025 |
| Snowervix Ltd | Wholesale & retail | 2019 |
| Snowreef Ltd | Transport & logistics | 2019 |
| Snuff Mill Management Ltd | Households | 2024 |
| SOC Ltd | Manufacturing | 2026 |
| Sodington Hall Limited | Real estate | 2013 |
| Sodington Limited | Real estate | 2016 |
| Sokolova Ltd | Arts & recreation | 2019 |
| SOL Solar Solutions Ltd | Construction | 2024 |
| Solar for Schools Ltd | Administrative & support | 2011 |
| SOLARPOWER4U Ltd | Energy | 2025 |
| Sold by the Bear Limited | Wholesale & retail | 2023 |
| Soletradr Limited | Wholesale & retail | 2026 |
| Solid Bond Limited | Professional & scientific | 2019 |
| Solid Surfacing Company Limited | Manufacturing | 2003 |
| Solidskin Ltd | Administrative & support | 2019 |
| Solutions Specialist Limited | Construction | 2018 |
| Somerleyton Properties Ltd | Real estate | 2025 |
| SOMETHING-QUIRKY-4U Limited | Wholesale & retail | 2014 |
| Sonnaz Traders Limited | Wholesale & retail | 2025 |
| Sophedeia Ltd | Wholesale & retail | 2019 |
| Sordicer Ltd | Administrative & support | 2024 |
| Sorockrem Ltd | Administrative & support | 2024 |
| Sotrack Ltd | Administrative & support | 2024 |
| Soucones Ltd | Health & social care | 2024 |
| Soufflé Fashion Ltd | Wholesale & retail | 2022 |
| Soulcraft Limited | Administrative & support | 2001 |
| Sound Discs Manufacturing Limited | Information & communication | 1996 |
| South Face Solar Ltd | Construction | 2023 |
| South Kilworth Ltd | Administrative & support | 2021 |
| South Newbald Ltd | Transport & logistics | 2021 |
| South West Construction (West Midlands) Ltd | Construction | 2016 |
| Southwill Holdings Limited | Financial services | 2021 |
| Sovereign Business Consultancy Limited | Professional & scientific | 2026 |
| Sovereign GAS Limited | Construction | 2022 |
| Spadpate Properties Limited | Real estate | 1976 |
| Spannerlife Ltd | Wholesale & retail | 2025 |
| Sparkza Ltd | Administrative & support | 2019 |
| Spartan Holdings Group Limited | Financial services | 2025 |
| Spartan Motor Holdings Limited | Administrative & support | 2008 |
| Spartan Trophies Ltd | Wholesale & retail | 2002 |
| Spartanalloys Ltd | Transport & logistics | 2019 |
| Spears Security Limited | Households | 2009 |
| Specialised Technical Services Limited | Administrative & support | 2006 |
| Specialist Foundations & Construction Limited | Construction | 2004 |
| Specialist Foundations and Piling Ltd | Construction | 2022 |
| Specialist Foundations Ltd | Construction | 2017 |
| Specialredfoods Ltd | Hospitality | 2019 |
| Speech and Language Therapy Hub Ltd | Health & social care | 2014 |
| Speed Fuels Ltd | Wholesale & retail | 2021 |
| Spennells Aerospace Solutions Ltd | Transport & logistics | 2016 |
| Spennells Takeaway Ltd | Hospitality | 2017 |
| Spenvale Limited | Real estate | 1994 |
| Spesbona Limited | Construction | 2004 |
| Spice Empire Restaurants Limited | Hospitality | 2015 |
| Spiced Right Limited | Manufacturing | 1996 |
| Spicehill Limited | Real estate | 2004 |
| Spinney View Woodwork Limited | Construction | 2020 |
| Spisdight Ltd | Administrative & support | 2024 |
| Splinters Flooring Ltd | Construction | 2022 |
| Spoke Technology Ltd | Information & communication | 2026 |
| Spongespark Ltd | Transport & logistics | 2019 |
| Sport IQ Ltd | Professional & scientific | 2006 |
| Spregdon Free Ltd | Administrative & support | 2022 |
| Spring ROW Ltd | Transport & logistics | 2022 |
| SPS Group Limited | Administrative & support | 2006 |
| Sraharory Ltd | Wholesale & retail | 2022 |
| Srovemear Ltd | Administrative & support | 2024 |
| SRR Europa Group Ltd | Construction | 2023 |
| SSC Care Services Limited | Health & social care | 2011 |
| ST4 Secure Storage LLP | | 2023 |
| Staggered Inns Limited | Hospitality | 2021 |
| Staletre Ltd | Administrative & support | 2024 |
| Stalvam Ltd | Administrative & support | 2024 |
| Stan Wall & SON (Timber) Limited | Agriculture & fishing | 2003 |
| Standbardfood Ltd | Wholesale & retail | 2019 |
| Stanier Properties Limited | Real estate | 2019 |
| Stanmore Mews Management Company Limited | Households | 2010 |
| Stapleton Accounting Solutions Ltd | Professional & scientific | 2013 |
| Starboard PCB Design Ltd | Information & communication | 2016 |
| Starethel Ltd | Wholesale & retail | 2019 |
| Stargaze Roofs Ltd | Manufacturing | 2021 |
| Starkie Property Limited | Hospitality | 2023 |
| Starry Construction Limited | Construction | 2023 |
| Start Construction Limited | Construction | 2003 |
| Startapp House Limited | Information & communication | 2023 |
| Steadman Hawkes Ltd | Financial services | 2018 |
| Steadymethod Ltd | Transport & logistics | 2019 |
| Steph Motors Limited | Wholesale & retail | 2025 |
| Stepple Farm Ltd | Professional & scientific | 2014 |
| Sterladmas Ltd | Administrative & support | 2019 |
| Stespray Limited | Wholesale & retail | 2024 |
| Steve Lloyd Electrical Limited | Manufacturing | 2023 |
| Steve Morris Agriculture Ltd | Wholesale & retail | 2024 |
| Steve Williams Construction West Midlands Ltd | Construction | 2020 |
| Steve Williams Hire Ltd | Administrative & support | 2025 |
| Steve Williams Holdings Limited | Financial services | 2025 |
| Steve's Garden & Property Maintenance Services Limited | Administrative & support | 2020 |
| Stevenson Couriers Ltd | Transport & logistics | 2022 |
| Stevetop Limited | Professional & scientific | 2015 |