| Eleven Lettings Limited | Real estate | 2019 |
| Elevessa Limited | Health & social care | 2025 |
| Elfia Property Limited | Real estate | 2020 |
| Elfinstone Ltd | Financial services | 2020 |
| Elgon Care Ltd | Health & social care | 2015 |
| Elite Aviation Surfacing Ltd | Construction | 2018 |
| Elite Civils Group Ltd | Construction | 2026 |
| Elite Decorating Northants Limited | Construction | 2026 |
| Elite Grab Hire Services Ltd | Water & waste | 2025 |
| Elite Heritage Autoworks Ltd | Wholesale & retail | 2025 |
| Elite Heritage Limited | Administrative & support | 2023 |
| Elite Heritage Sales Ltd | Wholesale & retail | 2023 |
| Elite KP Ltd | Hospitality | 2014 |
| Elite Luxury Homes Limited | Real estate | 2019 |
| Elite Meat & Dairy Products Co. Limited | Wholesale & retail | 2018 |
| Elite Surfacing & Installations Ltd | Construction | 2017 |
| Elite Survival Training Limited | Education | 2009 |
| Elitte Detailing Ltd | Wholesale & retail | 2026 |
| Elizabeth Vere Ltd | Wholesale & retail | 2025 |
| Elkington Gatic Limited | Construction | 1990 |
| Ellea Visual Design Ltd | Professional & scientific | 2021 |
| Elliot James Financial Services Ltd | Financial services | 2017 |
| Elliott Construction Anglia LLP | | 2007 |
| Elmore Capital Ltd | Education | 2024 |
| Elmore Developments Ltd. | Construction | 2007 |
| Elms Solutions Ltd | Financial services | 2024 |
| ELS Social Spark Ltd | Arts & recreation | 2024 |
| Elyven Logistics Limited | Transport & logistics | 2021 |
| EM Care and Recruitment Services Ltd | Administrative & support | 2026 |
| EM W Aesthetics Ltd | Health & social care | 2020 |
| EMB Building and Construction Ltd | Manufacturing | 2019 |
| Embrace Everything Ltd. | Health & social care | 2022 |
| Emcars Limited | Transport & logistics | 2024 |
| Emerald Care Ltd | Health & social care | 2002 |
| Emerge Healthcare Services Limited | Health & social care | 2022 |
| Emery Consulting Ltd | Professional & scientific | 2024 |
| Emet Limited | Health & social care | 2011 |
| Emily Louise Beauty & Aesthetics Ltd | Other services | 2019 |
| Emilys Electrical Limited | Manufacturing | 2025 |
| EMJ Process Engineering Ltd | Professional & scientific | 2021 |
| EMK Childcare Ltd | Health & social care | 2020 |
| Emma Proctor Designs Ltd | Information & communication | 2023 |
| Emmadave Associates Limited | Health & social care | 2019 |
| Emmant & SON Limited | Transport & logistics | 2016 |
| Empatia Dementia Ltd | Health & social care | 2024 |
| Emperor Coaching Limited | Administrative & support | 2019 |
| Empire Attire Ltd | Wholesale & retail | 2017 |
| Empire Local Limited | Administrative & support | 2016 |
| Empire Scaffolding Holdings Ltd | Financial services | 2023 |
| Empire Scaffolding Limited | Construction | 1997 |
| Emporium Roofing Limited | Construction | 2024 |
| Empress DRY Cleaners Limited | Other services | 2012 |
| Empty Property Seller Ltd | Real estate | 2025 |
| Emtmedical+ Ltd | Health & social care | 2019 |
| Enapay Consulting Ltd | Professional & scientific | 2023 |
| Endless Possibilities Agency Ltd | Information & communication | 2024 |
| Endless Possibility Care Ltd | Health & social care | 2023 |
| Endybg Ltd | Transport & logistics | 2021 |
| Energentia Consulting Ltd | Professional & scientific | 2026 |
| Enterprisemanufacturing Ltd | Administrative & support | 2026 |
| Entigen Ltd | Construction | 2021 |
| Envelope Solutions Ltd | Professional & scientific | 2009 |
| Envirovision Espu Ltd | Professional & scientific | 2025 |
| Envision Driving Limited | Professional & scientific | 2020 |
| Envision Energy Limited | Extraterritorial | 2022 |
| Enzi Solutions Ltd | Administrative & support | 2020 |
| Enzo Associates Limited | Professional & scientific | 2015 |
| EP Real Estate Holdings Ltd | Real estate | 2024 |
| EP1 Holdings Ltd | Financial services | 2024 |
| Epic Media Productions Limited | Information & communication | 2023 |
| Epic Moments Ltd | Wholesale & retail | 2025 |
| Epsilon Mechanical Ltd | Professional & scientific | 2025 |
| EPV Holdings Ltd | Financial services | 2024 |
| EPV Property & Building Solutions Ltd | Construction | 2024 |
| EPV Real Estate Ltd | Real estate | 2024 |
| Equal Value Limited | Administrative & support | 2023 |
| Equinox Aromas Limited | Manufacturing | 2000 |
| Equinox Organics Limited | Manufacturing | 1993 |
| Equisplash Limited | Agriculture & fishing | 2022 |
| Equity Kitchens Limited | Construction | 2015 |
| ER Beauty Studio Ltd | Other services | 2023 |
| Erea Property Ltd | Real estate | 2025 |
| ERG Builders Ltd | Other services | 2021 |
| ERG Property Group Ltd | Construction | 2026 |
| Erico Food & Drinks Ltd | Wholesale & retail | 2026 |
| Erictron AI Ltd | Information & communication | 2023 |
| Eroza Limited | Wholesale & retail | 2025 |
| Es&J Ltd | Health & social care | 2025 |
| Escape Everything Ltd. | Arts & recreation | 2014 |
| Eservuk Limited | Information & communication | 2022 |
| Esi-A Limited | Health & social care | 2019 |
| Eskdaill Place Management Company Limited | Households | 1988 |
| Eskz Ltd | Information & communication | 2023 |
| ESO Conveyancing Limited | Professional & scientific | 2026 |
| Esoire Limited | Other services | 2018 |
| Espiral Limited | Professional & scientific | 2014 |
| Espro Limited | Arts & recreation | 2005 |
| Essential Merchandise Limited | Wholesale & retail | 2011 |
| Estate Retail Ltd | Wholesale & retail | 2013 |
| Esteemed Property Solutions Limited | Construction | 2024 |