| Core Tutoring Ltd | Education | 2023 |
| Cosy Willow Ltd | Manufacturing | 2022 |
| Craig Charlton Electrical Services Ltd | Construction | 2019 |
| Crowd House Group Limited | Professional & scientific | 2017 |
| CS Event Hire Limited | Extraterritorial | 2015 |
| CTK Properties & Maintence Ltd | Households | 2025 |
| Curry ME Away Ltd | Hospitality | 2024 |
| CUT Print Solutions Ltd | Manufacturing | 2023 |
| D and C Commercial Cleaning Ltd | Administrative & support | 2022 |
| D G Neil Limited | Wholesale & retail | 2007 |
| D&S Rope Solutions Ltd | Administrative & support | 2023 |
| D.A.H Fabrication Limited | Administrative & support | 2016 |
| DAD V the Teenage Years Limited | Information & communication | 2026 |
| Daisy Electrical Services Limited | Other services | 2014 |
| Daley Access Ltd | Construction | 2019 |
| Danesfield Completions Ltd | Professional & scientific | 2015 |
| Darton Investments Ltd | Hospitality | 2019 |
| Davey Smith Renewables Ltd | Construction | 2025 |
| David Hanlon Ltd | Other services | 2025 |
| David Huddart Joinery & Building Ltd | Administrative & support | 2017 |
| Davidson Properties NE Ltd | Real estate | 2024 |
| DAW NE Ltd | Construction | 2026 |
| DCM Tech Ltd | Wholesale & retail | 2019 |
| Deaa Y Ltd | Transport & logistics | 2025 |
| Debuchi Universal Ltd | Wholesale & retail | 2026 |
| Dels Taxis Ltd | Transport & logistics | 2019 |
| Denton Manor Ltd | Real estate | 2022 |
| Derma-Repair Ltd | Health & social care | 2015 |
| DHC Properties Ltd | Real estate | 2025 |
| Dhms Group Ltd | Professional & scientific | 2020 |
| Diamond Drilling and Cutting Limited | Construction | 1998 |
| Different NOT Less Project CIC | Information & communication | 2026 |
| DIGI8 Limited | Professional & scientific | 2017 |
| Diverse - Fitness and Wellbeing CIC | Education | 2022 |
| DIY Epoxy Ltd | Information & communication | 2025 |
| DJ Daines Logistics Ltd | Transport & logistics | 2025 |
| DJ Joinery North East Limited | Construction | 2016 |
| DJB Engineering Solutions Ltd | Professional & scientific | 2021 |
| DJH Wills Limited | Professional & scientific | 2025 |
| DOH Bros Ltd | Hospitality | 2025 |
| Dove Offshore Services Ltd | Mining & quarrying | 2019 |
| DPM Building & Construction Ltd | Construction | 2021 |
| Drainway Plumbing NE Ltd | Construction | 2023 |
| DRM Building & Property Services Ltd | Construction | 2020 |
| DSO Facility and Flooring Ltd | Administrative & support | 2020 |
| DT LPG Technology UK Ltd | Professional & scientific | 2020 |
| Dtja Limited | Hospitality | 2018 |
| Dudu Ltd | Construction | 2025 |
| Dulay Enterprise Ltd | Hospitality | 2019 |
| Dunbar Energy Limited | Other services | 2025 |
| Dunlop Hevea (Industrial & Protective Footwear) Limited | Wholesale & retail | 1996 |
| Dunn Enterprises Limited | Extraterritorial | 2021 |
| DW Pipe Services Ltd | Mining & quarrying | 2013 |
| Dwellcome Home Ltd | Administrative & support | 2019 |
| Dynamic 121 Ltd | Arts & recreation | 2019 |
| E M Precision Limited | Manufacturing | 2020 |
| Eat@Quorum Limited | Hospitality | 2013 |
| Edgar Business Ltd | Professional & scientific | 2025 |
| Edinburgh Property Group Ltd | Real estate | 2024 |
| Edutainment Connect Limited | Education | 2024 |
| Edwards Offshore Limited | Construction | 2026 |
| Electronic Market Centre Limited | Wholesale & retail | 2026 |
| Elegant Software Ltd | Information & communication | 2015 |
| Elite Accountancy Solutions Ltd | Professional & scientific | 2019 |
| Elite Ventilation Services Ltd | Manufacturing | 2018 |
| Elvet Flooring Solutions Limited | Construction | 2024 |
| EMC (N.E.) Limited | Administrative & support | 2009 |
| EMD Environmental Services Limited | Construction | 2008 |
| EME Steel Profilers Ltd | Manufacturing | 2017 |
| Emerga Charge Ltd | Wholesale & retail | 2023 |
| Emma’S Exotic Animal Encounters Ltd | Arts & recreation | 2022 |
| Energy Surveys (EPC) North East Limited | Professional & scientific | 2008 |
| Enlightened Mind Ltd | Education | 2019 |
| Enterprise 3PL Limited | Transport & logistics | 2024 |
| ERF Barbers Ltd | Other services | 2021 |
| Ernest Group Ltd | Professional & scientific | 2025 |
| Estrella Limited | Real estate | 2024 |
| Eurokalk Limited | Transport & logistics | 2013 |
| Event Warehouse Limited | Arts & recreation | 2024 |
| Everfront Solutions Limited | Administrative & support | 2026 |
| Everstone Property Partners Limited | Real estate | 2025 |
| Everyday Competitions 4U Ltd | Arts & recreation | 2025 |
| EX PAT Tax Consultants Ltd | Professional & scientific | 2022 |
| Exemplified Global Enterprise Company Limited | Wholesale & retail | 2024 |
| F.D Access Ltd | Construction | 2024 |
| Fabrications by MR Wood Ltd | Construction | 2019 |
| Fairbairn Marquees Limited | Administrative & support | 2015 |
| Fansii Creations Ltd | Manufacturing | 2021 |
| Fastfit Cars and Vans Limited | Wholesale & retail | 2013 |
| Faye Tozer Limited | Arts & recreation | 2010 |
| FB168 Consultancy Limited | Professional & scientific | 2025 |
| Fenix NE Ltd | Hospitality | 2025 |
| Ferguseo Limited | Information & communication | 2025 |
| FG Trailers Limited | Manufacturing | 2004 |
| Filtex APC Ltd. | Manufacturing | 2018 |
| Findlay Todd Holdings Ltd | Administrative & support | 2023 |
| Findlay Todd Ltd | Professional & scientific | 2022 |
| Firewolf Services Ltd | Administrative & support | 2020 |
| First Anchor Consulting Limited | Professional & scientific | 2021 |
| First Care Support Ltd | Health & social care | 2023 |