| Ryde School | Education | 1947 |
| S.J. Clarke's Construction (I.O.W.) Limited | Construction | 2000 |
| Salesmatch Ltd | Professional & scientific | 2001 |
| Samels Limited | Hospitality | 2003 |
| Sandham Office Services Limited | Administrative & support | 2003 |
| Sandilands Copy Limited | Professional & scientific | 2024 |
| Sandown Airfield Ltd | Arts & recreation | 2015 |
| Senator Plant Hire Limited | Real estate | 1972 |
| Shanklin HK City Limited | Hospitality | 2017 |
| Sherri's Composites Limited | Manufacturing | 2024 |
| Solent Home Extensions Limited | Wholesale & retail | 1989 |
| Somerton Developments Limited | Real estate | 2002 |
| Sootseekers Property Services Limited | Construction | 2023 |
| Spence & Sons Limited | Agriculture & fishing | 1961 |
| Springfield and Teakwood Management Limited | Households | 2004 |
| ST Catherine's - Speech and Language | Education | 1983 |
| Staddlestones Garage Limited | Wholesale & retail | 2002 |
| Stanford Property Services Limited | Professional & scientific | 2004 |
| Steinberg House (IOW) Limited | Households | 2005 |
| Steve Ross Foundation for the Arts | Information & communication | 1976 |
| Stoneham IOW Ltd | Construction | 2017 |
| Stubbings Bros Holdings Limited | Financial services | 2021 |
| Stylish Plastics Limited | Construction | 2004 |
| Sunburst Corporation Limited | Real estate | 1999 |
| Sweetlime Limited | Information & communication | 2014 |
| Tempo Ventures Limited | Administrative & support | 1998 |
| Terence Michael Willey & Company Limited | Professional & scientific | 2001 |
| THE Brambles Management (I.O.W.) Company Limited | Households | 1998 |
| THE Grange Management Company (Bonchurch) Limited | Professional & scientific | 1997 |
| THE Holiday Shop Ltd | Administrative & support | 2014 |
| THE Island Copier Company Ltd | Real estate | 2001 |
| THE Isle of Wight Tramway Company Limited | Extraterritorial | 1998 |
| THE Jackson Family Ltd | Information & communication | 1996 |
| THE Old Smithy (IOW) Limited | Wholesale & retail | 2004 |
| THE Rufflers Way Residents Association Limited | Households | 1998 |
| THE Shide Court Association Limited | Households | 2002 |
| THE Sign Company Limited | Manufacturing | 1995 |
| THE Way Ahead School of Motoring Limited | Education | 2003 |
| TIM Hall Consulting Services Limited | Information & communication | 2013 |
| Tricycle Media Limited | Extraterritorial | 2018 |
| Tricycle Talent Limited | Administrative & support | 2019 |
| UK Sailing Academy | Education | 1988 |
| Uksa Trading Limited | Arts & recreation | 2007 |
| Univoice Limited | Information & communication | 1998 |
| V H Developments Limited | Construction | 2001 |
| Valint and Balk Limited | Information & communication | 2025 |
| Van Mossel IOW Limited | Wholesale & retail | 1946 |
| Vectawarm (Isle of Wight) Limited | Wholesale & retail | 1969 |
| Vectis Drylining and Ceilings Limited | Construction | 2006 |
| Ventnor Holiday Villas Limited | Real estate | 1999 |
| Victoria Road (Newport) Management Limited | Professional & scientific | 2004 |
| Vokins 2000 Limited | Real estate | 2002 |
| Volfsball Limited | Arts & recreation | 1983 |
| W.A.Souter & Son(Cowes)Limited | | 1961 |
| W.Hurst & Son.(I.W.)Limited | Wholesale & retail | 1961 |
| Warden Mount Freehold Company Limited | Households | 2017 |
| Wayne Isaacson Tree Consultancy Ltd | Professional & scientific | 2015 |
| Weaver Brothers Limited | Other services | 1957 |
| West Wight Nursery | Education | 2007 |
| West Wight Sports and Community Centre Trust Limited | Arts & recreation | 1976 |
| Westhill IOW Limited | Health & social care | 2005 |
| White Space Services Limited | Information & communication | 2019 |
| Wight Aviation Museum | Arts & recreation | 2017 |
| Wight Community Access Ltd | Transport & logistics | 2011 |
| Wight Tile Limited | Construction | 2001 |
| Wight Ventilation Specialists Limited | Construction | 2018 |
| Wightfibre Limited | Information & communication | 2005 |
| Wightworld Limited | Professional & scientific | 2000 |
| Wiltons of Shanklin Limited | Wholesale & retail | 1998 |
| Wing FC Limited | Hospitality | 2018 |
| Wootton Business Centre Limited | Real estate | 1991 |
| World Cruising Club Limited | Arts & recreation | 2005 |
| WP Recruitment & HR Ltd | Administrative & support | 2015 |
| YAR Limited | Financial services | 2002 |
| Yummy Tummy IOW Ltd | Hospitality | 2019 |