| SP Guard Ltd | Information & communication | 2026 |
| Space MGM LLP | | 2019 |
| Special Chicken Ltd | Hospitality | 2025 |
| Spectra Management L.P. | | 2013 |
| Spectro Trade L.P. | | 2014 |
| Speedstarterminal Ltd | Wholesale & retail | 2025 |
| Spence Plant Services Ltd | Transport & logistics | 2021 |
| Spence Transport Services Ltd | Transport & logistics | 2016 |
| Spey Electech Services Ltd | Energy | 2017 |
| Spey Systems Ltd | Information & communication | 2026 |
| Spey Valley Hire Centre Limited | Construction | 1988 |
| Spfr Limited | Professional & scientific | 2024 |
| Spice of Life Limited | Hospitality | 2025 |
| Spicey of Life Limited | Hospitality | 2026 |
| Spicy Spot Ltd | Hospitality | 2023 |
| Spilt Milk Ltd | Administrative & support | 2015 |
| Spirit Advocacy | Administrative & support | 2011 |
| Spirit Journeys Ltd | Administrative & support | 2015 |
| Sports Lining Services Ltd | Construction | 2024 |
| Sppm Ltd | Professional & scientific | 2023 |
| Springfield Europe L.P. | | 2013 |
| SSB Land Ltd | Construction | 2025 |
| ST Olaf Care Limited | Health & social care | 2020 |
| ST. Modans Care Home Limited | Health & social care | 1984 |
| Stag Communications Limited | Professional & scientific | 2023 |
| Stags Barbers Ltd | Other services | 2024 |
| Stalcair Ltd | Administrative & support | 2013 |
| Stanehoose Ltd | Real estate | 2023 |
| Stanford Tech Services Ltd | Construction | 2019 |
| Starlight Musical Theatre Limited | Arts & recreation | 2013 |
| Starport Alliance L.P. | | 2014 |
| Status Green Projects Limited | Professional & scientific | 2015 |
| Staunchest Holding LP | | 2016 |
| Stayinverness Limited | Hospitality | 2025 |
| Stayness Ltd | Real estate | 2024 |
| Steady Impacts LP | | 2016 |
| Steen Access Ltd | Construction | 2023 |
| Steen Building Services Ltd | Construction | 2018 |
| Steinhold LP | | 2018 |
| Stephen Leslie Limited | Manufacturing | 2019 |
| Steps Podiatry and Gait Ltd | Health & social care | 2024 |
| Sterner Aquatech UK Limited | Extraterritorial | 2023 |
| Stewart Ground Solutions Limited | Construction | 2018 |
| Stewart Mortgage Services Limited | Financial services | 2017 |
| Stillwater Risk Limited | Administrative & support | 2026 |
| Stoddart Engineering Ltd | Other services | 2021 |
| Stone Sales Limited | Manufacturing | 2024 |
| Stonemill Group LP | | 2018 |
| Stoneyfield Ltd | Real estate | 2019 |
| Stonnel Sales LP | | 2017 |
| Storr Electrical Services Ltd | Construction | 2010 |
| Story and Stage Limited | Information & communication | 1991 |
| Strategic 7 Ltd | Administrative & support | 2012 |
| Strategy Story Ltd | Professional & scientific | 2017 |
| Strath Services Scotland Limited | Professional & scientific | 2014 |
| Strathdearn Builders Limited | Construction | 2006 |
| Strathdearn Community Developments | Other services | 2013 |
| Strathdearn Limited | Professional & scientific | 2019 |
| Strathdearn Scottish Distillers Limited | Professional & scientific | 1994 |
| Stratherrick and Foyers Community Trust Limited | Other services | 2004 |
| Strathnairn Beach Cafe Ltd | Hospitality | 2020 |
| Strathnairn Community Benefit Fund Limited | Professional & scientific | 2004 |
| Strathnairn Community Woodlands | Agriculture & fishing | 2002 |
| Strathnairn Whisky Limited | Manufacturing | 1964 |
| Strathspey Mountain Hostel Ltd. | Hospitality | 2003 |
| Strawmack Construction Ltd | Extraterritorial | 2012 |
| Strength HQ Ltd | Arts & recreation | 2020 |
| Strut Digital Creative Ltd | Information & communication | 2006 |
| Stuart Dunbar Ltd | Wholesale & retail | 2022 |
| Stuart Macleod Painter & Decorator Limited | Construction | 2003 |
| Stuarts Cottages Ltd | Real estate | 2025 |
| Studio Highlands Ltd | Professional & scientific | 2024 |
| Stuff'D UP Ltd | Wholesale & retail | 2025 |
| Styland Property LP | | 2016 |
| Subsea Alba Limited | Mining & quarrying | 2012 |
| Subsea Marine International Limited | Professional & scientific | 2012 |
| Sueno IT Solutions Ltd | Information & communication | 2017 |
| Sultans Kitchen Ltd | Hospitality | 2020 |
| Summer Skye Property Ltd | Real estate | 2025 |
| Summit Highland Limited | Real estate | 2017 |
| Sun City Properties Inverness Ltd | Real estate | 2024 |
| Sunamul Ltd | Administrative & support | 2011 |
| Sunlex OIL LP | | 2016 |
| Sunnut Finance LP | | 2017 |
| Sunnybank Property Letting Ltd | Hospitality | 2026 |
| Superhosty Ltd | Hospitality | 2023 |
| Suprema Trade L.P. | | 2013 |
| Supremo L.P. | | 2015 |
| Supremo Systems L.P. | | 2013 |
| Surdail Limited | Professional & scientific | 2023 |
| Suresensors Limited | Professional & scientific | 2006 |
| Surface DR Limited | Construction | 2018 |
| Survey & Design Services Limited | Administrative & support | 1999 |
| Susan Mccreevy Artist Limited | Arts & recreation | 2024 |
| Sustainable Aquaculture Innovation Cluster Ltd | Professional & scientific | 2026 |
| Sutherland Engineering Limited | Real estate | 2003 |
| Sutherland Estates (Scotland) Limited | Professional & scientific | 2018 |
| Sutherland House Care Limited | Health & social care | 2025 |
| Sutherland Osteo Ltd | Health & social care | 2019 |
| Sutherland Property Group Ltd | Real estate | 2021 |