| Datoma Ltd | Professional & scientific | 1999 |
| Davise Property Limited | Real estate | 2025 |
| Dbsl Investments Limited | Professional & scientific | 2023 |
| Dbsl Property Limited | Real estate | 2015 |
| DBX Rail Limited | Professional & scientific | 2025 |
| DC Aesthetics & Training Academy Ltd | Education | 2022 |
| DDM Dismantling Limited | Financial services | 2016 |
| DE Biasio Properties Limited | Real estate | 1987 |
| Deakin Cleaning Services Limited | Administrative & support | 2020 |
| Deakin Smithson Ltd | Professional & scientific | 2025 |
| Deejaycee Ltd | Administrative & support | 2011 |
| Deerstone Homes Ltd | Construction | 2019 |
| Define Technologies Limited | Information & communication | 2000 |
| Deliverex Transport Ltd | Transport & logistics | 2008 |
| Demtech Services Limited | Construction | 2017 |
| Denehurst Chemical Safety Limited | Professional & scientific | 2000 |
| Denehurst Finance Partners Ltd | Professional & scientific | 2026 |
| Denton Properties Limited | Real estate | 1987 |
| Denton Reserve (Holdings) Limited | Financial services | 2020 |
| Denton Reserve (Hospitality) Limited | Hospitality | 2020 |
| Denton Reserve (Land) Limited | Agriculture & fishing | 2020 |
| Denwells Limited | Administrative & support | 2002 |
| Derbyshire Specialists Group Ltd | Construction | 2022 |
| Dereix Medical and Education Services Ltd | Health & social care | 2026 |
| Derek Powell Consultancy Ltd | Professional & scientific | 2011 |
| Design Emporium Limited | Administrative & support | 2002 |
| DESTECH2000 Limited | Professional & scientific | 2013 |
| Destination Homes Ltd | Construction | 2024 |
| Developing Success Ltd | Professional & scientific | 2006 |
| Devplan Limited | Administrative & support | 2004 |
| Dexastrong Limited | Professional & scientific | 2021 |
| Dexterity Group Holdings Limited | Financial services | 2024 |
| Dexterity Partners Limited | Professional & scientific | 2021 |
| Dexton Properties Ltd | Real estate | 2024 |
| DGL (Ilkley) Limited | Construction | 2006 |
| Diagram Industries Limited | Information & communication | 2017 |
| Diamond Lotus Group Ltd | Real estate | 2024 |
| Dickinson's of Addingham Limited | | 1978 |
| Dicky Deans Ltd | Manufacturing | 2024 |
| Didia Ltd | Other services | 2015 |
| Digi-Tal (UK) Ltd | Information & communication | 2011 |
| Digital Media Direct Limited | Professional & scientific | 2016 |
| Digital Minds Recruitment Ltd | Administrative & support | 2011 |
| Dillons Health and Fitness Limited | Arts & recreation | 2010 |
| Direct Authoring Ltd | Information & communication | 2022 |
| Direct Eastern European Trailers Ltd | Transport & logistics | 2001 |
| Direct Supply Limited | Wholesale & retail | 2005 |
| Direct Trailers Limited | Real estate | 2002 |
| Divine Universal Properties Ltd | Real estate | 2025 |
| DJC Management Consulting Limited | Professional & scientific | 2025 |
| DJD Performance Limited | Professional & scientific | 2012 |
| Djsa Consulting Limited | Professional & scientific | 2024 |
| DLS Physiotherapy Ltd | Health & social care | 2019 |
| Dobson Construction Limited | Construction | 2004 |
| Dotty Print Ltd | Wholesale & retail | 2014 |
| Dove in the Room Limited | Professional & scientific | 2019 |
| Doveash Property Management Limited | Households | 1984 |
| Down-At-Heel Limited | Construction | 1982 |
| Dowson Food Machinery Limited | Manufacturing | 2011 |
| DP Offplan Properties Ltd | Real estate | 2025 |
| DR Andrew Cobb Limited | Health & social care | 2013 |
| DR Michael O'Gorman Ltd | Health & social care | 2022 |
| Dracell UK Limited | Wholesale & retail | 2016 |
| Drake and Macefield Limited | Wholesale & retail | 2002 |
| Dream Catcher Properties Ltd | Real estate | 2026 |
| Drivegain Limited | Information & communication | 2008 |
| Driven Athlete Ltd | Arts & recreation | 2022 |
| Drunk Uncle Ltd | Hospitality | 2024 |
| DTB Management Services Limited | Professional & scientific | 2025 |
| Dunchurch UK Ltd | Real estate | 2026 |
| DWR Landscapes Ltd | Professional & scientific | 2021 |
| Dynamic Event Management Limited | Other services | 2015 |
| Dysons Corner Stores Ltd | Wholesale & retail | 2026 |
| E & H Estate Agents Limited | Real estate | 2013 |
| E & J Developments Yorkshire Ltd | Administrative & support | 2023 |
| E a Clinic Limited | Health & social care | 2009 |
| E H Decorating Ltd | Construction | 2023 |
| E Muirhead Ltd | Health & social care | 2014 |
| E Prenga Bathrooms Ltd | Construction | 2019 |
| E Prenga Bathrooms&Tiles Ltd | Construction | 2024 |
| E. G. Wilson Limited | Real estate | 1934 |
| E2BN Protex Limited | Education | 2008 |
| Eagle Express Europe Ltd | Wholesale & retail | 2025 |
| East London Electric Company Ltd | Health & social care | 2019 |
| Eastwood UK Properties Limited | Real estate | 1993 |
| EBI Tuition Limited | Education | 2020 |
| Ebilc Ltd | Other services | 2026 |
| Eco-Cigarette (Middlesbrough) Ltd | Wholesale & retail | 2019 |
| Ecogpx Ltd | Information & communication | 2024 |
| Ecogrill UK Ltd | Wholesale & retail | 2018 |
| Ecomtrad Limited | Other services | 2019 |
| Eden Squared Ltd | Information & communication | 2025 |
| Edenbean Limited | Real estate | 2009 |
| Edenborough Associates Limited | Administrative & support | 2006 |
| Edged International Education Consultancy Limited | Professional & scientific | 2025 |
| Effra Associates Limited | Education | 2025 |
| EFO20 Limited | Real estate | 2025 |
| Ehah Properties Ltd | Real estate | 2023 |
| EJR Estates Ltd | Real estate | 2024 |
| Elcrest Yorks Limited | Hospitality | 2019 |