| Playeredge Ltd | Education | 2023 |
| Playgirl Ltd | Manufacturing | 2025 |
| Plumbing Heating & Design Limited | Construction | 2011 |
| Plumbing Industry Short Courses Limited | Education | 2022 |
| Pounds Meadow Braunton Ltd | Real estate | 2019 |
| Powerful Tickets Ltd | Administrative & support | 2026 |
| Precision Scaffolding Ltd | Construction | 2019 |
| Promenade Gifts Ilfracombe Limited | Wholesale & retail | 2017 |
| Protect the Human Limited | Information & communication | 2024 |
| Prudzani Ltd | Health & social care | 2020 |
| PTL Forestry Limited | Agriculture & fishing | 2020 |
| PV Lettings Limited | Real estate | 2025 |
| Pyracantha Limited | Professional & scientific | 1998 |
| Quay Shoes Limited | Wholesale & retail | 2003 |
| Quickcalc Limited | Information & communication | 2006 |
| R and T Business Ltd | Hospitality | 2026 |
| RAD Chugg Ltd | Construction | 2022 |
| Raddy Racing Ltd | Arts & recreation | 2024 |
| Rbpi-Uk Limited | Financial services | 2020 |
| Real Business Applications EOT Limited | Financial services | 2026 |
| Real Business Applications Limited | Information & communication | 1991 |
| Rebel Leisure Direct Ltd | Wholesale & retail | 2023 |
| Red Admiral Letting Agents Limited | Real estate | 2007 |
| Redvers (UK) Ltd | Extraterritorial | 2011 |
| Renovate Devon Ltd | Construction | 2022 |
| Response Ready Ltd | Administrative & support | 2025 |
| Retco 1 Limited | Wholesale & retail | 2020 |
| Rethink Maintenance Limited | Construction | 2021 |
| RH Electrical Contractors (South West) Limited | Construction | 2019 |
| Ricch Devon Ltd | Wholesale & retail | 2020 |
| Richardsons the Sweet People Ltd | Wholesale & retail | 2003 |
| Ridiculous Solutions (SW) Ltd | Arts & recreation | 2019 |
| Rillage Ltd | Real estate | 2024 |
| Ritepriceuk Ltd | Wholesale & retail | 2025 |
| Riverflow Residents Association Limited | Households | 1983 |
| RJ Willis Heating Ltd | Construction | 2019 |
| RK Quality Solutions Ltd | Professional & scientific | 2017 |
| Rock Paper Film Limited | Wholesale & retail | 2017 |
| Rockcliffe Management (2001) Limited | Households | 2001 |
| Rockfield Road Management Limited | Households | 2006 |
| Rogan Creative Ltd | Information & communication | 2025 |
| Rone House Management Company Limited | Households | 2006 |
| RS Farming Limited | Agriculture & fishing | 2014 |
| Runnacleave Court Apartments Management Limited | Households | 2020 |
| RW Property Solutions Ltd | Construction | 2019 |
| Ryan Miles Mobile Fish & Chips Ltd | Hospitality | 2010 |
| S + H Technical Support Limited | Administrative & support | 2003 |
| Sage Cottage Tearoom Ltd | Hospitality | 2024 |
| Salt Wood Ltd | Agriculture & fishing | 2016 |
| Sana Organica Limited | Health & social care | 2020 |
| Saville Place Management Limited | Households | 1987 |
| Scarlet Pimpernel Cars Limited | Real estate | 1948 |
| Scarlett Group Europe Ltd | Real estate | 2024 |
| SCC Construction & Development Limited | Manufacturing | 2023 |
| Scolopax Consulting Ltd | Information & communication | 2015 |
| Screenpath Computing Limited | Information & communication | 1995 |
| Sea Rock Apartments Management Company Limited | Households | 2006 |
| Seacroft Gifts Limited | Wholesale & retail | 2012 |
| Seaview Developments SW Ltd | Construction | 2024 |
| Seneca Property Maintenance T/A Seneca Commercial Carpet Cleaning Ltd | Administrative & support | 2022 |
| Serenity Apartments Management Company Ltd | Households | 2020 |
| Serve the Vibe Ltd | Wholesale & retail | 2026 |
| Sevenfold Properties Ltd | Real estate | 2022 |
| Sevenfold Retail Ltd | Other services | 2024 |
| Seventythree Foundation | Professional & scientific | 2022 |
| Shannic One Construction Ltd | Construction | 2016 |
| Shindig Events Ltd | Administrative & support | 2024 |
| Silk Crystal Studio Ltd | Wholesale & retail | 2021 |
| Silverdale Hire Ltd | Administrative & support | 2020 |
| Site Engineering Southwest Ltd | Construction | 2015 |
| SJ Fleming Associates Ltd | Professional & scientific | 2025 |
| Slice of Devon Ltd | Hospitality | 2018 |
| SLT Ilfracombe Ltd | Hospitality | 2025 |
| Smarter Appliances Ltd | Manufacturing | 2014 |
| Smarter Business Investments Ltd | Financial services | 2023 |
| Smarter Fleet Management Ltd | Information & communication | 2025 |
| Smarter Web Development Ltd | Information & communication | 2023 |
| SMD Pharmacy Ltd | Wholesale & retail | 2018 |
| SMH Building Ltd | Construction | 2023 |
| Smokey Cloudz Ltd | Wholesale & retail | 2024 |
| SMT Assets Limited | Real estate | 2006 |
| Softec Ltd | Information & communication | 2001 |
| Soilet Systems Limited | Water & waste | 2009 |
| Soundboat Ltd | Information & communication | 2019 |
| South Leigh Limited | Professional & scientific | 2000 |
| South TOR Apartments Ltd | Households | 2015 |
| South West Curiers Ltd | Transport & logistics | 2025 |
| South West Real Estate Ltd | Real estate | 2025 |
| Spirit Level Cinema Limited | Information & communication | 1999 |
| Spiritus AER Ltd | Arts & recreation | 2025 |
| SSC BIO Limited | Professional & scientific | 2016 |
| Stapleton Farms Ltd | Agriculture & fishing | 2012 |
| Star Dust Wines Ltd | Wholesale & retail | 2018 |
| Starcloth and Drape Hire Limited | Professional & scientific | 2009 |
| Steam Pickett Ltd | Construction | 2019 |
| Sterling Managers Limited | Real estate | 2012 |
| Steve Wightman Limited | Administrative & support | 2012 |
| Sthale Ltd | Hospitality | 2025 |
| Stone Building Solutions Ltd | Water & waste | 2026 |
| Stowford Leisure Ltd | Wholesale & retail | 2020 |