| Surecert Electrical Ltd | Other services | 2018 |
| Surefire Management Services Limited | Construction | 2017 |
| Suren Ltd | Information & communication | 2024 |
| Surepotential Ltd | Administrative & support | 2011 |
| Suretask Ltd | Information & communication | 2019 |
| Surrey and Hampshire Racing Limited | Professional & scientific | 2026 |
| Surrey Builders Limited | Construction | 1979 |
| Survin Limited | Real estate | 2026 |
| Susanna Young Limited | Hospitality | 2022 |
| Sussex & Southern Estates Ltd | Real estate | 2015 |
| Sussex Academy of Music Limited | Education | 2008 |
| Sussex Accountancy Services (S.E.) Limited | Professional & scientific | 2004 |
| Sussex ACM Solutions Ltd | Water & waste | 2020 |
| Sussex Acorns Ltd | Education | 2006 |
| Sussex Actually Ltd | Manufacturing | 2026 |
| Sussex and Brighton Learning Community CIC | Health & social care | 2025 |
| Sussex Automation Services Limited | Information & communication | 2006 |
| Sussex Back Pain Clinic Limited | Health & social care | 2002 |
| Sussex Backup Limited | Information & communication | 2003 |
| Sussex Blinds Limited | Extraterritorial | 2009 |
| Sussex Block Management Ltd | Real estate | 2020 |
| Sussex Boiler & Plumbing Services Ltd | Construction | 2021 |
| Sussex BPM Limited | Construction | 2020 |
| Sussex Business & Project Management Ltd | Administrative & support | 2022 |
| Sussex Business Compliancy Solutions Limited | Construction | 2011 |
| Sussex Cardiovascular Clinic Ltd | Financial services | 2019 |
| Sussex Caterers Ltd | Hospitality | 2024 |
| Sussex Clean Team Ltd | Administrative & support | 2020 |
| Sussex Commercial Properties Limited | Real estate | 2025 |
| Sussex Cricket Estates Limited | Construction | 2018 |
| Sussex Cricket Foundation | Education | 2015 |
| Sussex Day Nurseries Limited | Health & social care | 2024 |
| Sussex Downs Construction Ltd | Construction | 2024 |
| Sussex Educational Psychology Ltd | Education | 2024 |
| Sussex Estates Limited | Real estate | 1988 |
| Sussex Fitness Holdings Ltd | Arts & recreation | 2025 |
| Sussex Foot Surgery Limited | Health & social care | 2013 |
| Sussex Framing Solutions Ltd | Professional & scientific | 2025 |
| Sussex Funeral Services Ltd | Other services | 2010 |
| Sussex Go Ltd | Transport & logistics | 2021 |
| Sussex Heritage Properties Limited | Real estate | 1998 |
| Sussex Home Solutions Limited | Construction | 2022 |
| Sussex Investments UK Limited | Real estate | 2017 |
| Sussex Letting Shop Ltd | Extraterritorial | 2013 |
| Sussex Maths Tutor Ltd | Education | 2020 |
| Sussex Mortgage Services Limited | Financial services | 2016 |
| Sussex Open Ltd | Arts & recreation | 2019 |
| Sussex Outdoors Life Ltd | Administrative & support | 2023 |
| Sussex Pads Ltd | Real estate | 2021 |
| Sussex Plumbing Solutions Ltd | Construction | 2018 |
| Sussex Precision Plumbing and Heating Ltd | Construction | 2020 |
| Sussex Property Services Ltd | Wholesale & retail | 2008 |
| Sussex Psychiatric Services Ltd | Health & social care | 2009 |
| Sussex Reliance Taxi Ltd | Transport & logistics | 2024 |
| Sussex Sash Window Restoration Ltd | Construction | 2015 |
| Sussex Scoops Limited | Hospitality | 2025 |
| Sussex SEO Ltd | Administrative & support | 2013 |
| Sussex Skin Doctor Limited | Health & social care | 2022 |
| Sussex Skin Services Limited | Real estate | 2009 |
| Sussex Speedy Recovery’S Limited | Wholesale & retail | 2025 |
| Sussex TA Ltd | Administrative & support | 2026 |
| Sussex Tools Limited | Wholesale & retail | 1992 |
| Sussex Tree Works Ltd | Agriculture & fishing | 2022 |
| Sussex Window Works Ltd | Construction | 2023 |
| Sustain Futures Limited | Professional & scientific | 2012 |
| Sustainable Evolution at Home Ltd. | Professional & scientific | 2006 |
| Sustainable Evolution Ltd. | Professional & scientific | 2004 |
| Sustainable Furniture London Ltd | Manufacturing | 2019 |
| Sustainable Resourcing Limited | Administrative & support | 2011 |
| Sustainpath Advisory Ltd | Professional & scientific | 2026 |
| Suters Yard Ltd | Hospitality | 2013 |
| Suzanne Rogers Ltd | Administrative & support | 2015 |
| SW Architects Ltd | Professional & scientific | 2002 |
| SW10 London Ltd | Real estate | 2017 |
| SW16 Pizza Ltd | Hospitality | 2021 |
| Swag Limited | Wholesale & retail | 2011 |
| Swainson Property Maintenance Limited | Construction | 2012 |
| Swallowmead (Steyning)) Limited | Households | 2007 |
| Swan Computer Services Limited | Professional & scientific | 1983 |
| Swanborough Court (Shoreham-By-Sea) Management Company Limited | Households | 1992 |
| Sweet and Sour Limited | Wholesale & retail | 2025 |
| Sweet Crude Ltd | Information & communication | 2012 |
| Sweet Software Limited | Information & communication | 2017 |
| Sweetielicious Ltd | Wholesale & retail | 2018 |
| Swell AI Momentum Ltd | Information & communication | 2024 |
| Swenk Ltd | Wholesale & retail | 2013 |
| Swindon Solar Farm Ltd | Energy | 2014 |
| Swingfirst Limited | Real estate | 1986 |
| Swish Hair Ltd | Other services | 2018 |
| Swlock Ltd | Information & communication | 2022 |
| Sword Lily Limited | Real estate | 2023 |
| Swordman Ltd | Professional & scientific | 2023 |
| Sycamine Ltd | Real estate | 2021 |
| Sydneyplus International Library Systems (UK) Limited | Information & communication | 1998 |
| Symmetric Networks Limited | Administrative & support | 2011 |
| Symmetry International Limited | Professional & scientific | 2020 |
| Symposium Tours Limited | Administrative & support | 2020 |
| Symva Coffee Limited | Wholesale & retail | 2022 |
| Syndicateexpressuk Ltd | Wholesale & retail | 2025 |
| Synergy Capital UK Limited | Professional & scientific | 1999 |