| SGM Commercial Services Limited | Professional & scientific | 2016 |
| SGW Ravelin Limited | Administrative & support | 2018 |
| SH Applications Ltd | Professional & scientific | 2025 |
| Shades of Grape Ltd | Arts & recreation | 2014 |
| Shadi Danin Limited | Health & social care | 2002 |
| Shadi's Hairdresser Ltd | Wholesale & retail | 2019 |
| Shahjalal Muslim Cultural Centre (Brighton and Hove) Ltd. | Other services | 2016 |
| Shakier & Co Ltd | Real estate | 2023 |
| Shakil Civil Engineering Limited | Professional & scientific | 2012 |
| Shalchi Property Limited | Real estate | 2021 |
| Sham Bodie Limited | Administrative & support | 2026 |
| Shamboozle Limited | Hospitality | 2018 |
| Shanadary Limited | Wholesale & retail | 2024 |
| Shandiz Hove Ltd | Hospitality | 2024 |
| Shannon Property Management Limited | Real estate | 1990 |
| Shape Architecture Ltd | Professional & scientific | 2006 |
| Sharon LEE Design Limited | Wholesale & retail | 2021 |
| Sharp Intelligence Ltd | Information & communication | 2022 |
| Sharp Medical Solutions Ltd | Health & social care | 2019 |
| Sharpys Woodworking & Developments Ltd | Construction | 2021 |
| Shatterhand Ltd | Real estate | 2019 |
| SHC Dental Limited | Health & social care | 2023 |
| SHE Sees Ltd | Professional & scientific | 2024 |
| Sheaf Energy Limited | Construction | 2021 |
| Sheldrick AI Ltd | Information & communication | 2025 |
| Shelf Direct Ltd | Manufacturing | 2012 |
| Shepherds Builders Limited | Construction | 2013 |
| Shereen Limited | Health & social care | 2019 |
| Shiftjump Ltd | Information & communication | 2024 |
| Shima Property Ltd | Real estate | 2021 |
| Shine and Tidy Cleaning Services Ltd | Administrative & support | 2024 |
| Shine Consultancy Group Limited | Professional & scientific | 2019 |
| Shineonbrighton Cleaning Ltd | Administrative & support | 2021 |
| Shingle & Shore Stays Ltd | Hospitality | 2026 |
| Shipment Scout Limited | Information & communication | 2026 |
| Shipton Capital Ltd | Professional & scientific | 2026 |
| Shiraz Kitchen Limited | Hospitality | 2026 |
| Shivansi Limited | Wholesale & retail | 2020 |
| Shlok & YOM Limited | Wholesale & retail | 2018 |
| SHO Invest Ltd | Administrative & support | 2025 |
| Shoot ME NOW Ltd | Professional & scientific | 2014 |
| Shore Accounting Ltd | Professional & scientific | 2011 |
| Shore Construction Group Limited | Construction | 2011 |
| Shore Executive Travel Ltd | Professional & scientific | 2017 |
| Shore Group Logistics Ltd | Administrative & support | 2022 |
| Shore GRP Resources LLP | | 2015 |
| Shore Integrated Services Limited | Administrative & support | 2004 |
| Shore Professional Services Limited | Professional & scientific | 2010 |
| Shore Stage Scaffolding Ltd | Construction | 2021 |
| Shore Technology LLP | | 2021 |
| Shoreham Carpets & Flooring Ltd | Wholesale & retail | 2019 |
| Shoreham Scaffolding & Plant Hire Ltd | Construction | 2019 |
| Shoreham-By-Sea Oyster Company Ltd | Wholesale & retail | 2020 |
| Shoreline Electrical Solutions Ltd. | Households | 2024 |
| Shoreline Property Holdings Limited | Financial services | 2026 |
| Shoreline Property Services Ltd | Real estate | 2025 |
| Shorestone Limited | Financial services | 2023 |
| Shorters Kitchens Ltd | Hospitality | 2024 |
| Shortgrass Limited | Wholesale & retail | 1999 |
| Shortlock Ltd | Arts & recreation | 2024 |
| Shorts Financial Services LLP | | 2004 |
| Shot by Women Ltd | Professional & scientific | 2020 |
| Shoutaboutit Limited | Professional & scientific | 2004 |
| Show Binary Ltd | Professional & scientific | 2021 |
| Shreem 888 Limited | Information & communication | 2025 |
| Shriram Pharma Ltd | Wholesale & retail | 2025 |
| Shut UP & SIT Down Ltd. | Information & communication | 2014 |
| Shutterly Fabulous Retail Limited | Wholesale & retail | 2006 |
| Shuttleworth Solar Limited | Energy | 2012 |
| Siam Precision Partners Limited | Professional & scientific | 2026 |
| Siam Style Limited | Wholesale & retail | 2009 |
| Sick BOI Ltd | Wholesale & retail | 2022 |
| Sidaravicius Ltd | Transport & logistics | 2017 |
| Sideline Assembly C.I.C. | Education | 2023 |
| Sidestreet Hair Limited | Extraterritorial | 2015 |
| Sidewinder Kitchen Ltd | Hospitality | 2026 |
| Sidewinder Management Limited | Professional & scientific | 2013 |
| Sidola & Co Limited | Real estate | 2023 |
| SIE Associates Limited | Professional & scientific | 2023 |
| SIG International Limited | Public administration | 2026 |
| Sige Semiconductor (Europe) Limited | Professional & scientific | 2000 |
| Sigmar Ltd | Real estate | 2026 |
| Sillwood Court Limited | Households | 2004 |
| Sillwood Mansions Residents Association Limited | Households | 1976 |
| Silver Birch Close Management Company Ltd | Construction | 2017 |
| Silver Cowboy Limited | Administrative & support | 2014 |
| Silver SOL Ltd | Administrative & support | 2025 |
| Silver Street Properties Limited | Real estate | 1996 |
| Silverforce Coaching Ltd. | Administrative & support | 2009 |
| Silverline Digital Labs Ltd | Information & communication | 2025 |
| Silvertech Engineering Limited | Professional & scientific | 2015 |
| Silvertech Limited | Construction | 2015 |
| Silverwood MAN Co Ltd | Real estate | 2026 |
| Simhomes Property Limited | Real estate | 2013 |
| Simon Andrew Starr Ltd | Information & communication | 2011 |
| Simon Beavis Communications Ltd | Information & communication | 2021 |
| Simon Howard Consulting Limited | Professional & scientific | 2023 |
| Simon Khalil Properties Limited | Real estate | 2023 |
| Simon Tierney Limited | Information & communication | 2008 |
| Simon Way Limited | Professional & scientific | 2013 |