| Saint Preestigious Ltd | Manufacturing | 2025 |
| Salon Performance Limited | Professional & scientific | 2024 |
| Salsa Brighton Dance Ltd | Arts & recreation | 2026 |
| Salt & Stone Advisory Ltd | Professional & scientific | 2026 |
| Salt Air Stories Ltd | Education | 2026 |
| Salt Bookkeeping Ltd | Professional & scientific | 2017 |
| Salt Space Limited | Other services | 2014 |
| Saltair Limited | Health & social care | 2021 |
| Saltbeef Productions Limited | Information & communication | 2005 |
| Saltbeef TV Limited | Information & communication | 2010 |
| Saltbeef TV2 Limited | Information & communication | 2018 |
| Saltbeef TV3 Limited | Information & communication | 2020 |
| Salter Sullivan Ltd | Other services | 2017 |
| Salterp Ltd | Information & communication | 2026 |
| Saltieri Limited | Hospitality | 2012 |
| Saltire Investments Limited | Real estate | 1990 |
| Salty Earth Ltd | Wholesale & retail | 2024 |
| Salvis Network Ltd | Other services | 2017 |
| SAM Barber (SB) Ltd | Real estate | 2024 |
| SAM Davis Roofing Ltd | Construction | 2023 |
| SAM Leicester Therapeutic Services Ltd | Other services | 2015 |
| SAM Lock Art Ltd | Arts & recreation | 2018 |
| SAM Property Golden Group Ltd | Real estate | 2017 |
| Sama Alliance PLC | Information & communication | 2023 |
| Samah Holdings Ltd | Real estate | 2019 |
| Samambaya International Limited | Professional & scientific | 2006 |
| Samba DE Bamba UK Ltd | Education | 2021 |
| Sample Clearance Services Limited | Professional & scientific | 1998 |
| Samsara Consulting Ltd | Professional & scientific | 2012 |
| Samson Rosie Limited | Financial services | 2018 |
| Samuel Chapman Salon Ltd | Other services | 2015 |
| Samuel Lecky Ltd | Professional & scientific | 2023 |
| SAN John Ltd | Information & communication | 2014 |
| Sanches.Com Limited | Information & communication | 2002 |
| Sancus Security Design Ltd | Professional & scientific | 2025 |
| Sandcan Limited | Health & social care | 2021 |
| Sandhutton Solar Project Limited | Energy | 2014 |
| Sandown Court Hove Limited | Extraterritorial | 2009 |
| Sang Development Ltd | Construction | 2022 |
| Sangha Lettings Limited | Real estate | 2021 |
| Sanmaaya Limited | Real estate | 2023 |
| Sanna Annukka Limited | Arts & recreation | 2006 |
| Sanscript Consultancy Limited | Real estate | 1999 |
| Sansom Consultants Ltd | Professional & scientific | 2021 |
| Sansom Enterprises Ltd | Arts & recreation | 2011 |
| Santer Joinery Ltd | Manufacturing | 2008 |
| Santiago Group Ltd | Real estate | 2024 |
| Santler Mitten Limited | Construction | 2016 |
| Saom Ltd | Administrative & support | 2016 |
| Sapphire Gold Ltd | Real estate | 2016 |
| Sapphire Medical Group Limited | Health & social care | 2024 |
| Sarah Bolam Communications Limited | Professional & scientific | 2012 |
| Sarah King Interiors Ltd | Professional & scientific | 2021 |
| Saratoga Realisations Ltd | Real estate | 2010 |
| Saron Solar Limited | Energy | 2011 |
| Saross Consultancy Ltd | Information & communication | 2019 |
| Sarron Investments Limited | Administrative & support | 2010 |
| Sarson & Darby Ltd | Arts & recreation | 2020 |
| Saryas Fresh Limited | Wholesale & retail | 2024 |
| Sasha Nash Ltd | Professional & scientific | 2025 |
| Sassy Sommelier Ltd | Other services | 2017 |
| Sat-Insure Limited | Administrative & support | 2006 |
| Satellite 4 U Limited | Financial services | 2008 |
| Satori Living Ltd | Wholesale & retail | 2025 |
| Saul Projects Limited | Information & communication | 2009 |
| Sauna & Stretch Ltd | Other services | 2025 |
| Saunders Management Development Limited | Professional & scientific | 2005 |
| Savage Heart Ltd | Arts & recreation | 2020 |
| Sawna Llan Ltd | Other services | 2026 |
| Sawyer & Co Financial Services Limited | Financial services | 2023 |
| Sawyer & Co Sales & Lettings Limited | Real estate | 2001 |
| Saxon Down Properties Limited | Construction | 2016 |
| Saxthorpe Holdings Ltd | Real estate | 2025 |
| Saxthorpe Properties Limited | Extraterritorial | 2005 |
| Saya 34 Ltd | Information & communication | 2020 |
| SB Signature Stays Limited | Real estate | 2025 |
| SBA Dental Limited | Health & social care | 2023 |
| SBD Ltd | Health & social care | 2019 |
| Sbec Contract Services Ltd | Administrative & support | 2024 |
| SBS Accountancy and Taxation Services Limited | Professional & scientific | 2014 |
| SBS Building Services Limited | Construction | 1987 |
| Scalers Hill Pigs Limited | Wholesale & retail | 2014 |
| Scandi Design & Build Ltd | Professional & scientific | 2022 |
| Scarlet Marlin Limited | Information & communication | 2012 |
| Scarlett Jewellery Limited | Wholesale & retail | 2003 |
| SCC Simulation Ltd | Information & communication | 2015 |
| Scelti Clinic Ltd | Health & social care | 2026 |
| Scelti Nutrition Ltd | Health & social care | 2026 |
| Schmetterling Productions Ltd | Arts & recreation | 2025 |
| Schmidt C Consult Limited | Professional & scientific | 2017 |
| School of the Wild Ltd | Extraterritorial | 2021 |
| Scienion (UK) Limited | Professional & scientific | 2019 |
| SCJ Taylor Consulting Ltd | Professional & scientific | 2018 |
| SCL Control Systems Limited | Information & communication | 2010 |
| Scoremidable Ltd | Information & communication | 2025 |
| Scott INQ Ltd | Information & communication | 2018 |
| Scott Lift Services Ltd | Manufacturing | 2009 |
| Scott Newsom Ltd | Information & communication | 2015 |
| Scotties Café 2024 Ltd | Hospitality | 2024 |
| Scotties Hove Cafe Limited | Hospitality | 2017 |