| Rennoldson Property Maintenance Limited | Households | 2025 |
| Renocourts Ltd | Administrative & support | 2023 |
| Retreat Homes Ltd | Real estate | 2024 |
| Retrocars (North East) Ltd | Wholesale & retail | 2024 |
| RFM Property Services Limited | Construction | 2026 |
| RHR Property Ltd | Real estate | 2022 |
| Richard Coates Limited | Health & social care | 2016 |
| Richard Martin Automotive Solutions Ltd | Wholesale & retail | 2015 |
| Richfield Estates Ltd | Real estate | 2019 |
| Richstone Family Holdings Limited | Financial services | 2025 |
| Rigby-Affiliates Ltd | Professional & scientific | 2014 |
| Rippon Construction Limited | Construction | 2009 |
| Rippon Developments Limited | Extraterritorial | 2022 |
| RJC Groundworks Limited | Construction | 2017 |
| RJL Fencing Ltd | Construction | 2024 |
| RLB Northeast Ltd | Construction | 2026 |
| RLI Properties Ltd | Households | 2026 |
| RLM Group Ltd | Professional & scientific | 2016 |
| RMP Company Secretarial Services Ltd | Other services | 2016 |
| RMP Services NE Ltd | Hospitality | 2023 |
| ROB Barry Groundworks Limited | Construction | 2019 |
| Roberto Monerri Limited | Hospitality | 2016 |
| Robson-Scott Sports Management Limited | Arts & recreation | 2014 |
| Rockwood Estates N.E Limited | Real estate | 2006 |
| Rocolo Limited | Administrative & support | 2009 |
| Roll With IT ( South Shields ) Ltd | Construction | 2025 |
| Ronbar Ltd | Extraterritorial | 2022 |
| Rose Health & Safety Training Ltd | Other services | 2006 |
| Roseberry Club Leisure Limited | Hospitality | 1994 |
| Rosefield Energyfarm Limited | Energy | 2018 |
| Ross Elliott Ltd | Wholesale & retail | 2025 |
| Ross Hodgson Creative Studios Ltd | Professional & scientific | 2019 |
| Roza Garden Rooms Ltd | Construction | 2023 |
| RPG Maintenance & Inspections Ltd | Mining & quarrying | 2025 |
| RR Windows Ltd | Construction | 2026 |
| Rraw Enterprises Ltd | Information & communication | 2015 |
| RTJ Consulting NE Limited | Professional & scientific | 2025 |
| Rubber Duck Holdings Limited | Financial services | 2020 |
| Rusholme Windfarm Limited | Energy | 2008 |
| Russo Trattoria Ltd | Hospitality | 2019 |
| Ryhope Convenience Store Ltd | Wholesale & retail | 2019 |
| Ryland Engineering Ltd | Construction | 2020 |
| S & D Contractors & Construction Limited | Construction | 2025 |
| S Fuller Ltd | Construction | 2020 |
| S Nicholson & Sons Limited | Construction | 2011 |
| S Wood Vehicle Movement Ltd | Wholesale & retail | 2006 |
| S&A Core Solutions Ltd | Hospitality | 2025 |
| S&C Bargains Ltd | Wholesale & retail | 2024 |
| S.A.A (North East) Ltd | Hospitality | 2024 |
| S.B.A Waste and Groundworks Ltd | Construction | 2026 |
| S.I.S Modelling Limited | Professional & scientific | 2026 |
| Safe and Secure Properties Shiney ROW Ltd | Real estate | 2014 |
| Safe Utility Solutions Ltd | Construction | 2025 |
| Safer Streets Ltd | Administrative & support | 2018 |
| Saihaj Convenience Store Ltd | Wholesale & retail | 2014 |
| SAM Raincock Consultancy Limited | Information & communication | 2011 |
| Samantha Jayne’S Hair Studio Ltd | Other services | 2022 |
| Sambuca London Ltd | Hospitality | 2021 |
| Sancroft Group Ltd | Households | 2025 |
| Sand Dancer Limited | Manufacturing | 2024 |
| Sandhu Capital Investments Ltd | Real estate | 2020 |
| Sarah Conway Ltd | Real estate | 2021 |
| SAS Energy Limited | Energy | 2024 |
| SAS Plastering Specialists Limited | Construction | 2019 |
| Satgur Limited | Hospitality | 2023 |
| Satsa Club Ltd | Hospitality | 2025 |
| Saxon Property and Maintenance Ltd | Construction | 2013 |
| SB Estates NE Ltd | Real estate | 2024 |
| School Services International Ltd | Professional & scientific | 2022 |
| Scott and Kelsey Scaffolding Ltd | Construction | 2025 |
| Scott Digital Ltd | Information & communication | 2020 |
| Scott Robson Management (UK) LLP | | 2017 |
| SCR Products and Services Ltd | Wholesale & retail | 2025 |
| SD Legal Services Ltd | Other services | 2007 |
| Sea Road Ltd | Hospitality | 2018 |
| Seahorse Neuropsychology Ltd | Health & social care | 2025 |
| Sealants (UK) Limited | Construction | 2008 |
| Seaton Delaval Sport Property Limited | Arts & recreation | 2026 |
| Secret of Abundance Ltd | Health & social care | 2022 |
| SEE Things Limited | Professional & scientific | 2014 |
| Sekura Commercials Limited | Manufacturing | 2020 |
| Select Interiors (North East) Limited | Manufacturing | 2007 |
| Self Care Saturday Ltd | Wholesale & retail | 2021 |
| Semen LAB Ltd | Wholesale & retail | 2025 |
| Sexton Dogs Ltd | Agriculture & fishing | 2023 |
| Sgnn Ltd | Other services | 2024 |
| Shado Hasso Property Ltd | Real estate | 2026 |
| Shaheenco Limited | Manufacturing | 2020 |
| Shark Digital Displays Limited | Information & communication | 2020 |
| Shelly Equine Assisted Therapy CIC | Arts & recreation | 2025 |
| Shen Chakuch Ltd | Wholesale & retail | 2025 |
| Shields Solutions Limited | Information & communication | 2020 |
| Shindar Hasso Ltd | Other services | 2022 |
| Shiney Advice & Resource Project | Health & social care | 2003 |
| Shiney Nails Spa Ltd | Other services | 2025 |
| Shiney Paws Ltd | Wholesale & retail | 2022 |
| Shiney ROW 168 Limited | Hospitality | 2025 |
| Shiptalk Limited | Administrative & support | 2002 |
| Shukranaa Ltd | Wholesale & retail | 2025 |
| Siam Supreme NE Ltd | Hospitality | 2023 |