| Nepr Limited | Construction | 2013 |
| Nesham Private Nursery Limited | Education | 2011 |
| Neshmusic Ltd | Arts & recreation | 2026 |
| Neuroinc Ltd | Information & communication | 2023 |
| New Futures Social Care Ltd | Health & social care | 2023 |
| New Gloss Limited | Other services | 2024 |
| New Herrington Ltd | Real estate | 2018 |
| New PWR NKU Limited | Transport & logistics | 2021 |
| New Results Ltd | Professional & scientific | 2012 |
| Newbottle Rivaaj Ltd | Hospitality | 2025 |
| Newcastle Deli Limited | Hospitality | 2018 |
| Nexacivil Infrastructure Ltd | Construction | 2026 |
| NGJ Bookkeeping & Payroll Limited | Professional & scientific | 2010 |
| NGT Group Ltd | Real estate | 2023 |
| NGT Heating Ltd | Construction | 2021 |
| Nicbro (Holdings) Limited | Financial services | 2019 |
| Nichol Associates Limited | Construction | 2004 |
| Nimishambika Private Limited | Wholesale & retail | 2025 |
| Ninth Wave Ventures Limited | Professional & scientific | 2025 |
| Nipa Limited | Administrative & support | 2001 |
| NNN Facilities Management Ltd | Construction | 2024 |
| Noble FL Ltd | Wholesale & retail | 2025 |
| Nordigo Ltd | Transport & logistics | 2025 |
| North East Hydro Ltd | Wholesale & retail | 2020 |
| North East Interior Solutions Ltd | Construction | 2025 |
| North East Plumbing and GAS Services Ltd | Energy | 2020 |
| North East Podiatry Limited | Health & social care | 2012 |
| North East Property Service Limited | Construction | 2013 |
| North East Retail Ltd | Wholesale & retail | 2025 |
| North East Rover Owner's Club Limited | Arts & recreation | 1990 |
| North East Tiling Services Limited | Construction | 2024 |
| North East Wedding Network Ltd | Information & communication | 2025 |
| North Leisure Products Ltd | Wholesale & retail | 2009 |
| North Riviera Retail Ltd | Wholesale & retail | 2024 |
| North West Wedding Network Ltd | Manufacturing | 2025 |
| Northern Construction Solutions Limited | Construction | 2002 |
| Northern Contractors NE Ltd | Construction | 2023 |
| Northman Technical Ltd | Professional & scientific | 2023 |
| Northpoint Cleaning Co. Ltd | Administrative & support | 2026 |
| Northside Consultants Ltd | Professional & scientific | 2026 |
| NOT a Statistic Northeast CIC | Other services | 2023 |
| NS Chowdary Ltd | Hospitality | 2025 |
| NSC Associates Limited | Professional & scientific | 2021 |
| Nuvoke Ltd | Construction | 2019 |
| Nvpwtq Limited | Wholesale & retail | 2025 |
| Oak Dene Transport Limited | Transport & logistics | 2025 |
| Oakes Energy Services Ltd | Construction | 2007 |
| Oaktree Construction NE Ltd | Construction | 2026 |
| Octave Solutions Ltd | Information & communication | 2020 |
| OH SO Delicious Media Limited | Professional & scientific | 2026 |
| OLA Fencing Ltd | Construction | 2026 |
| Oldpost Ltd | Hospitality | 2013 |
| Ollyfaith Property Ltd | Real estate | 2022 |
| Omino Ltd | Health & social care | 2011 |
| Only Food NOT Horses Ltd | Wholesale & retail | 2025 |
| Onlyfabs Ltd | Manufacturing | 2025 |
| Onsneakzuk Ltd | Wholesale & retail | 2026 |
| Open Minds Psychological Therapy Service Limited | Health & social care | 2014 |
| OPS Consulting Ltd | Public administration | 2025 |
| Optimum Smart Repairs Ltd | Wholesale & retail | 2025 |
| Orchid Medical Secretarial Services Ltd | Administrative & support | 2025 |
| Orilla Construction Solutions Limited | Professional & scientific | 2019 |
| OTL Family Trading Limited | Wholesale & retail | 2024 |
| OUR Minds Work Limited | Professional & scientific | 2006 |
| Oval Tax Consultants Limited | Professional & scientific | 2019 |
| Overwatch IT Ltd | Professional & scientific | 2020 |
| P&F Landscaping Ltd | Administrative & support | 2019 |
| P.D.M (North East) Limited | Manufacturing | 1997 |
| Pacifica Appliance Services Limited | Other services | 2004 |
| Pacifica Group Limited | Administrative & support | 2005 |
| Pacifica Limited | Extraterritorial | 2020 |
| Pada Capital Holdings Limited | Extraterritorial | 2021 |
| Pakway Limited | Manufacturing | 2016 |
| Palace of Fencehouses Limited | Hospitality | 2025 |
| Pali Pizza Ltd | Hospitality | 2020 |
| Palmyra Retail Limited | Wholesale & retail | 2026 |
| Panda Easington Limited | Hospitality | 2019 |
| Paper and Park Ltd | Wholesale & retail | 2025 |
| Parcel Delivery People Ltd | Transport & logistics | 2025 |
| Parkgate Group Limited | Transport & logistics | 2016 |
| Parlett Financial Limited | Financial services | 2014 |
| Pato Property Ltd | Real estate | 2024 |
| Paul Stephenson Electrical Ltd | Construction | 2023 |
| Pawsitive Hoofbeat Ltd | Wholesale & retail | 2023 |
| Pawsome Pet Pantry Ltd | Wholesale & retail | 2024 |
| Pawtastic Ltd | Wholesale & retail | 2023 |
| Pdjp Ltd | Hospitality | 2024 |
| PDK (N.E) Limited | Transport & logistics | 2007 |
| Peach Garden Penshaw Limited | Hospitality | 2025 |
| Peach Garden Takeaway Ltd | Hospitality | 2012 |
| Pearl Girl Kingdom Ltd | Wholesale & retail | 2025 |
| Pebble Magic Ltd | Construction | 2014 |
| Pendeford Metal Spinnings Limited | Manufacturing | 1971 |
| Penshaw Car Clinic Limited | Wholesale & retail | 2017 |
| Penshaw Consultancy Ltd | Professional & scientific | 2008 |
| Penshaw Equestrian Centre Limited | Other services | 2019 |
| Penshaw Indian Restaurant Limited | Hospitality | 2024 |
| Penshaw Prospect PUB Company Ltd | Hospitality | 2025 |
| Penshaw Rope Access Ltd | Manufacturing | 2024 |
| Penshaw View Enterprises Limited | Education | 2008 |