| SPC Acquisitions 5 Limited | Financial services | 2018 |
| Spearhead Advisory Limited | Extraterritorial | 2010 |
| Specfin Group Ltd | Financial services | 2024 |
| Specfin Properties Ltd | Financial services | 2024 |
| Specialist Data Holdings Limited | Information & communication | 2013 |
| Specialist Data Software Limited | Information & communication | 1996 |
| Specialist Data Solutions Ltd | Information & communication | 1990 |
| Specialist Holidays (Travel) Limited | Administrative & support | 1947 |
| Specialist Joinery & Interiors Limited | Construction | 2019 |
| Specialist Nursing Solutions Ltd | Health & social care | 2017 |
| Speed Checked Ltd | Arts & recreation | 2020 |
| Speedy Bill Limited | Information & communication | 2023 |
| Speedy TV Aerial Services Limited | Professional & scientific | 2020 |
| Spesmilo Ltd | Extraterritorial | 2021 |
| Spiers Consultancy Ltd | Professional & scientific | 2024 |
| Spike's Sight Words Ltd | Education | 2022 |
| Spinnaker IT Consulting Ltd | Information & communication | 2017 |
| Spire Investment Group Ltd | Financial services | 2016 |
| Spire Platform Holdings Ltd | Financial services | 2026 |
| Spire Ventures JV Ltd | Financial services | 2023 |
| Spire Ventures Ltd | Administrative & support | 2012 |
| Spire View Limited | Professional & scientific | 2012 |
| Spirit Displays Limited | Manufacturing | 2002 |
| Spiritas Limited | Information & communication | 1996 |
| Spiritit Ltd | Information & communication | 2016 |
| Spiritland Productions Limited | Information & communication | 2018 |
| Spiritual Communications Limited | Information & communication | 2015 |
| SPK Health Limited | Health & social care | 2023 |
| Splash Entertainment Ltd | Arts & recreation | 2024 |
| Splashtacular (UK) Ltd | Manufacturing | 2017 |
| Spock Enterprises Ltd | Administrative & support | 2012 |
| Sporting Success Limited | Arts & recreation | 2012 |
| Sports Brokers Ltd | Wholesale & retail | 1994 |
| Sports Horses International Ltd | Wholesale & retail | 2004 |
| Sports Stars UK Limited | Education | 2012 |
| Sportscapes Enterprises Limited | Construction | 2025 |
| Sportsme Limited | Information & communication | 2025 |
| Spotless Professional Cleaning Services Limited | Administrative & support | 2025 |
| Spotty Dotty Ltd | Wholesale & retail | 2023 |
| SPP Air Conditioning Services Limited | Administrative & support | 2004 |
| SPR Heating Limited | Construction | 2021 |
| SPR Property & Development Ltd | Real estate | 2021 |
| Spreagadh Limited | Wholesale & retail | 2025 |
| Spring Park Capital LLP | | 2014 |
| Springboard Project | Arts & recreation | 1992 |
| Springfield Park (NO. 1) Management Company Limited | Households | 1998 |
| Springfield Park (NO. 2) Management Company Limited | Households | 1998 |
| Springfield Reim Limited | Financial services | 2022 |
| Springhill Products Limited | Manufacturing | 2013 |
| Sproul Aviation Ltd | Transport & logistics | 2018 |
| Spry Lifestylez Limited | Information & communication | 2012 |
| Spydasoft Limited | Information & communication | 2004 |
| Square EYE Retro Arcade Ltd | Hospitality | 2024 |
| Square Slice Consultancy Ltd | Administrative & support | 2022 |
| Squires (Advisory) Limited | Administrative & support | 2020 |
| Squires Engineering Limited | Real estate | 2019 |
| SR BUS Ltd | Arts & recreation | 2024 |
| Srec Ltd | Administrative & support | 2025 |
| SRI Sairam Engineering Ltd | Information & communication | 2012 |
| Srli Ltd | Wholesale & retail | 2015 |
| SSC Construction Services Ltd. | Construction | 1984 |
| SSC Contractors Limited | Construction | 2015 |
| Sslb Ltd | Professional & scientific | 2023 |
| SSS Removals Ltd | Water & waste | 2025 |
| ST George's Scaffolding (Southern) Ltd | Construction | 2021 |
| ST Leonard's RD Limited | Administrative & support | 2026 |
| ST Lighting Limited | Other services | 2016 |
| ST. Mary's Close Residents Association (Billingshurst) Limited | Households | 1987 |
| Stack Investments Limited | Real estate | 2016 |
| Stackley Management Limited | Real estate | 2015 |
| Staddon Advisory Group Ltd | Professional & scientific | 2025 |
| Stage X Media Ltd | Administrative & support | 2026 |
| Stagescripts Ltd | Administrative & support | 2007 |
| Stags Leap Limited | Financial services | 2010 |
| Stalagmite Consulting Limited | Professional & scientific | 2019 |
| Standby Self Storage Limited | Real estate | 2010 |
| Stanhill Analytic Limited | Professional & scientific | 2011 |
| Staples 7 Management Limited | Real estate | 2023 |
| Star Build Limited | Professional & scientific | 2014 |
| Star Concept Ltd | Wholesale & retail | 2021 |
| Starbuild Environmental Ltd | Construction | 2023 |
| Starfire Limited | Professional & scientific | 2009 |
| Stargazing Studio Ltd | Information & communication | 2023 |
| Starline Translation Limited | Professional & scientific | 2008 |
| Stars and Stripes Classics Ltd | Wholesale & retail | 2026 |
| Starshine Advisors Ltd | Professional & scientific | 2025 |
| Station Garage Horsham Ltd | Wholesale & retail | 2020 |
| Station Road (Horsham) Management Company Limited | Households | 1980 |
| Station Road Otford Management Company Limited | Professional & scientific | 2022 |
| Stavelot Commercial Management Limited | Professional & scientific | 2023 |
| Stay Sharp Men's Grooming Ltd | Other services | 2017 |
| Steadfast (IT) Consulting Ltd. | Information & communication | 2012 |
| Steadlands International Marketing Limited | Administrative & support | 1993 |
| Steamco Limited | Manufacturing | 2006 |
| Steban's Hair Studio Ltd. | Other services | 2006 |
| Steellane Trading Ltd | Wholesale & retail | 2025 |
| Stella Aurea Ltd | Financial services | 2018 |
| Stenton Holdings Ltd | Professional & scientific | 2021 |
| Step UP Physiotherapy Ltd | Health & social care | 2018 |
| Step UP Strength Ltd | Arts & recreation | 2021 |