| Spaces Design Limited | Construction | 2024 |
| SPACES2GROW Workspace Ltd | Real estate | 2023 |
| Sparkmate Ltd | Information & communication | 2025 |
| Specialist Orthodontic Practice Limited | Health & social care | 2018 |
| Specialist Project Solutions Limited | Administrative & support | 2009 |
| Specialist Rail Solutions Ltd | Transport & logistics | 2007 |
| Speedyfan Ltd | Construction | 2024 |
| Speedysnack Limited | Hospitality | 2024 |
| Spencers Railway Ltd | Administrative & support | 2023 |
| SPH Bhangal Limited | Administrative & support | 2004 |
| SPH Capital Limited | Real estate | 2022 |
| Spick and Spandy Ltd | Administrative & support | 2017 |
| Spiderweb Systems.Net Limited | Information & communication | 2000 |
| Spine Balance Ltd | Health & social care | 2022 |
| Spire View Court Freehold Limited | Households | 2022 |
| Sponsorguard Ltd | Administrative & support | 2026 |
| Sport Intent Ltd | Education | 2026 |
| Sports Knee Physio Ltd | Health & social care | 2024 |
| Springfield Car Wash Ltd | Wholesale & retail | 2018 |
| Springfield Health Limited | Health & social care | 2024 |
| Spruce Laundry Engineering & Consultancy Limited | Other services | 2002 |
| Spry Ltd | Wholesale & retail | 2024 |
| Squad Fitness Limited | Arts & recreation | 2016 |
| Square Edge Interiors Ltd | Construction | 2024 |
| Square EGG Productions Limited | Information & communication | 2015 |
| Square Stay Ltd | Hospitality | 2023 |
| Squareplot Limited | Real estate | 2024 |
| Squarezoned Limited | Wholesale & retail | 2023 |
| Squishy Corner Ltd | Construction | 2020 |
| Squpsies Ltd | Other services | 2023 |
| SR & DJ Ventures Limited | Other services | 2013 |
| SR Barbers Ltd | Other services | 2023 |
| SR Capital Ltd | Real estate | 2023 |
| SRC 2016 Limited | Administrative & support | 2016 |
| SRI Veera Bhadra Services Ltd | Wholesale & retail | 2023 |
| Srigo Consulting Limited | Information & communication | 2018 |
| Srikaran Solutions Ltd | Information & communication | 2022 |
| SRM Haji Group Ltd | Wholesale & retail | 2025 |
| Srps Limited | Health & social care | 2007 |
| SRW Heating & Plumbing Ltd | Construction | 2018 |
| SRZ Builds Ltd | Construction | 2019 |
| SS Global Investments Ltd | Financial services | 2024 |
| SS Property Ltd | Real estate | 2017 |
| SS Vehicle Security Ltd | Wholesale & retail | 2026 |
| SSB Universal Ltd | Transport & logistics | 2025 |
| Ssbt Estates Ltd | Real estate | 2024 |
| Ssbt Intellects Ltd | Information & communication | 2018 |
| SSC Portfolios Ltd | Real estate | 2025 |
| Sscf Limited | Health & social care | 2010 |
| SSJ Advisory Limited | Professional & scientific | 2025 |
| SSK London Property Limited | Real estate | 2022 |
| SSP Property Ventures Ltd | Real estate | 2024 |
| SSW Services Limited | Health & social care | 2025 |
| ST Clements Oral Surgery Limited | Health & social care | 2020 |
| ST James (Partnership) Properties Limited | Real estate | 2026 |
| ST Michaels Rest Home Ltd | Health & social care | 2018 |
| ST Nicholas Avenue 1967 Limited | Extraterritorial | 2015 |
| ST Pharma Limited | Other services | 2015 |
| Stabana Limited | Real estate | 2011 |
| Stacey's Auctioneers Limited | Wholesale & retail | 2025 |
| Stacey's Beauty and Wellbeing Ltd | Other services | 2019 |
| Stacknflow Ltd | Wholesale & retail | 2025 |
| Stadium Bathroom Properties Limited | Real estate | 2022 |
| Stadium Bathrooms Limited | Construction | 2013 |
| Stafx Limited | Construction | 2017 |
| Stallion Chauffeur Services Ltd | Transport & logistics | 2024 |
| Stanbourne Group Limited | Construction | 2025 |
| Stanford Solutions Limited | Wholesale & retail | 2026 |
| Stanley Carpentry Limited | Administrative & support | 2024 |
| Stanley Education Advisory Services Ltd | Professional & scientific | 2023 |
| Star Catering & Dining Ltd | Hospitality | 2025 |
| Star Memorabilia Limited | Wholesale & retail | 2013 |
| Star Mini Cabs Ltd | Administrative & support | 2005 |
| Starline Autoparts Limited | Wholesale & retail | 2023 |
| Starling Medical Limited | Health & social care | 2026 |
| Starling Survey Ltd | Information & communication | 2026 |
| Starrbeautyy Ltd | Other services | 2023 |
| Stars Accountants Limited | Professional & scientific | 2017 |
| Stars Consultants Limited | Professional & scientific | 2020 |
| Stars Law Limited | Other services | 2019 |
| Starsec Services Ltd | Administrative & support | 2019 |
| Starsmile Plus Limited | Health & social care | 2022 |
| Station Parade Lounge Ltd | Hospitality | 2017 |
| Staunch Properties Limited | Real estate | 2023 |
| Staunch Support Limited | Public administration | 2023 |
| Stavely Way Properties Limited | Real estate | 2024 |
| Stayweb Ltd | Information & communication | 2021 |
| STC Building Solutions Ltd | Construction | 2021 |
| Stcosmetics Limited | Other services | 2024 |
| Steel Build Masters Limited | Construction | 2006 |
| Steels ARE US Ltd | Construction | 2014 |
| Stefan Carpenter Ltd | Construction | 2023 |
| Stellar Labels Ltd | Manufacturing | 2026 |
| Stellar Property Solutions Ltd | Construction | 2023 |
| Stellar Shift Consulting Limited | Professional & scientific | 2025 |
| Stellar Sound Productions Limited | Arts & recreation | 2021 |
| Step Property Finance Limited | Financial services | 2020 |
| Step Property Group Limited | Administrative & support | 2006 |
| Step Property Limited | Real estate | 1992 |
| Stephen Anderson Limited | Health & social care | 2017 |