| Pro-Light Supplies UK Ltd | Wholesale & retail | 2025 |
| Property Management (Greenfield) Limited | Extraterritorial | 2013 |
| Protagoras Forensic Services & Intervention Limited | Health & social care | 2009 |
| Protectoseal Ltd | Manufacturing | 2007 |
| PS Training Limited | Information & communication | 2000 |
| Puffin House Residential Ltd | Health & social care | 2020 |
| Purple Patch Broking Ltd | Information & communication | 2014 |
| Purple Patch Performance Limited | Professional & scientific | 2011 |
| Pxlc Limited | Professional & scientific | 2010 |
| Quantus Project Consulting Ltd | Professional & scientific | 2025 |
| Quinte Limited | Professional & scientific | 2010 |
| R. E. C. Haulage Limited | Transport & logistics | 2018 |
| R.O Agri & Plant Ltd | Wholesale & retail | 2024 |
| RAE Catering Ltd | Hospitality | 2024 |
| Ramp Inns Limited | Hospitality | 2024 |
| Rapt Leisure Limited | Professional & scientific | 2017 |
| Rbts Rentals Limited | Real estate | 2024 |
| Rebecca Hughes Ltd | Professional & scientific | 2014 |
| Red Chestnut Properties Ltd | Real estate | 2021 |
| Red Dragon GSE Ltd | Wholesale & retail | 2020 |
| Red Dragon Ventures Ltd | Arts & recreation | 2016 |
| Reference ME Ltd | Administrative & support | 2023 |
| Regenacaps Ltd | Wholesale & retail | 2025 |
| Regit Limited | Extraterritorial | 2000 |
| Rejuvenescence Ltd | Wholesale & retail | 2022 |
| Remontoire 68 Limited | Wholesale & retail | 2018 |
| Resin Driveway Company RDC Ltd | Construction | 2020 |
| RGJ Engineering Ltd | Manufacturing | 2014 |
| Rhyl & District Motor Club Limited | Arts & recreation | 1979 |
| Ringden Projects Limited | Construction | 2019 |
| Ringway Training Limited | Education | 2012 |
| Rising Stronger CIC | Education | 2024 |
| RKP Engineering Limited | Manufacturing | 2011 |
| Robinson Motorsport Limited | Arts & recreation | 2006 |
| Roots & Wings Child Day Care Ltd | Education | 2021 |
| Rose Networks Ltd | Information & communication | 2019 |
| Rose Tree Farm Boarding Limited | Agriculture & fishing | 2017 |
| RPJ Timber Framing Ltd | Manufacturing | 2022 |
| Rtbtech Limited | Other services | 2017 |
| Rubicontract Limited | Professional & scientific | 2020 |
| S a Home Improvements Ltd | Construction | 2022 |
| S V Services Rubbish Removeals Ltd | Wholesale & retail | 2026 |
| S.B.B. Limited | Construction | 1996 |
| Saco Ltd | Construction | 2019 |
| Safe Lifting Operations Ltd | Construction | 2020 |
| Safety First Electrical Limited | Construction | 2006 |
| Sangrisieo Ltd | Agriculture & fishing | 2024 |
| Sauviter Limited | Transport & logistics | 2010 |
| Saver Glass Ltd | Construction | 2019 |
| Saver Group Ltd | Construction | 2020 |
| Scaffold Supremacy Ltd | Administrative & support | 2025 |
| Schofeildpropertyholding Ltd | Real estate | 2022 |
| SDL Fire & Security Limited | Administrative & support | 2016 |
| Seaview Joinery Services Ltd | Construction | 2019 |
| Seek HS Limited | Agriculture & fishing | 2024 |
| Serenity Property Management Ltd | Real estate | 2024 |
| SES Park Works Limited | Real estate | 2013 |
| SET Free Projects Limited | Manufacturing | 2003 |
| Sewing GEM Ltd | Wholesale & retail | 2021 |
| SFX Hire Limited | Arts & recreation | 2012 |
| Shadowoption Limited | Construction | 1992 |
| Shamack Consultancy Limited | Professional & scientific | 2014 |
| Shed & Fencing World Limited | Manufacturing | 2005 |
| Shock Airsoft Ltd | Arts & recreation | 2020 |
| Shortys Properties Ltd | Real estate | 2014 |
| Side Step Events Limited | Arts & recreation | 2025 |
| Silver Fern Performance Ltd | Wholesale & retail | 2015 |
| Simon Lloyd Electrical Limited | Extraterritorial | 2016 |
| Simplified Management Systems Ltd | Professional & scientific | 2013 |
| Singar Limited | Administrative & support | 2007 |
| SJ Poultry Limited | Agriculture & fishing | 2008 |
| SME Solutions Group Limited | Administrative & support | 2021 |
| SML (NW) Limited | Construction | 2023 |
| Solar FIX North West & Wales Ltd | Construction | 2026 |
| Solar Power Provider UK Limited | Construction | 2011 |
| Solutions for Parks Ltd | Wholesale & retail | 2019 |
| Sorrel and Sage Woodland Wisdom Ltd | Health & social care | 2021 |
| SOS Hose Services Limited | Administrative & support | 1997 |
| Soul Sister Wellness CIC | Education | 2021 |
| Soulcareuk Ltd | Information & communication | 2025 |
| Spitfire Digital Ltd | Information & communication | 2022 |
| ST Johns Properties Limited | Real estate | 2014 |
| ST Peters Square Limited | Real estate | 2012 |
| ST Winefrides Close Management Company Limited | Real estate | 2016 |
| Stages for Events Ltd | Arts & recreation | 2016 |
| Stamford Gate Developments Limited | Real estate | 2008 |
| Stamford Gate Holdings Limited | Financial services | 2022 |
| Stamford Gate Hotel Limited | Hospitality | 1993 |
| Stamporium Limited | Wholesale & retail | 2025 |
| Status Construction North West Limited | Construction | 2015 |
| Steezbomb Limited | Wholesale & retail | 2016 |
| Steph's Beauty Lounge Limited | Other services | 2015 |
| Sturla Agricultural Services Ltd | Other services | 2017 |
| Sunlitdrops Ltd | Wholesale & retail | 2026 |
| Super-Spray (Europe) Limited | Professional & scientific | 2009 |
| Superexcess Limited | Professional & scientific | 1993 |
| Suzu Consultants Limited | Information & communication | 2009 |
| SW Traders Ltd | Wholesale & retail | 2013 |
| Sweet Caroline's Competitions Ltd | Wholesale & retail | 2021 |
| Sylfaen Property Ltd | Construction | 2025 |