| Shakville Estates Ltd | Real estate | 2025 |
| Sharp & Tappin Technology Ltd | Manufacturing | 2003 |
| Shepherd Medical Ltd | Health & social care | 2024 |
| Shires Construction Limited | Construction | 2008 |
| SHOPPING4DISCOUNT Limited | Other services | 2006 |
| Short & Abbott Limited | Manufacturing | 2001 |
| Sibi Vita Ltd | Agriculture & fishing | 2025 |
| Sign Team (Bedfordshire) Limited | Manufacturing | 2013 |
| Signgeer Limited | Manufacturing | 2000 |
| Silver Spoon Hospitality Group Ltd | Hospitality | 2021 |
| Slingo Properties Limited | Real estate | 2024 |
| Sluggett Limited | Transport & logistics | 2002 |
| Smokey Sam’S Ltd | Hospitality | 2025 |
| Solar Heart Limited | Construction | 2025 |
| Somachology Ltd | Health & social care | 2026 |
| Sotherby Sanders & Partners Limited | Professional & scientific | 1996 |
| South West Sports Boats Limited | Construction | 1997 |
| South West Steel Construction Limited | Construction | 2007 |
| Southview Home Care Ltd | Health & social care | 2020 |
| Sparkling Health UK Limited | Wholesale & retail | 2001 |
| Spicer Homes Limited | Real estate | 2022 |
| SPL Training Ltd | Education | 2024 |
| ST. Anne's Residential Home Limited | Health & social care | 2012 |
| Sterling Property Solutions (Home Counties) Limited | Construction | 2013 |
| Steyn Operations Ltd | Construction | 2022 |
| Still Management Consultancy Limited | Professional & scientific | 2023 |
| Stone Building Limited | Construction | 2000 |
| Stonebridge Estate & Development Limited | Construction | 2025 |
| Stop GAP Fencing Limited | Administrative & support | 2009 |
| Stratton Deanery CIC | Other services | 2025 |
| Strivonex Ltd | Information & communication | 2020 |
| Summit Holdings (SW) Ltd | Financial services | 2026 |
| Superforma Limited | Wholesale & retail | 2011 |
| Swannacott Manor HOG Roast Ltd | Hospitality | 2017 |
| SWT Ltd | Administrative & support | 2023 |
| T T Engineering & Fabrication Limited | Manufacturing | 2019 |
| T. Cook Limited | Agriculture & fishing | 1999 |
| Tamar Land & Property Company Holdings Limited | Construction | 2014 |
| Tamar Land & Property Company Limited | Construction | 2014 |
| Tamar Roofing & Building Services Ltd | Construction | 2026 |
| Tamar Valley Holidays Limited | Hospitality | 2024 |
| Tamarstone Limited | Construction | 2020 |
| Tamerworthy Ltd | Real estate | 2025 |
| Tarka Kitchens Ltd | Manufacturing | 2026 |
| TCH Enterprises Limited | Construction | 2013 |
| Tech Electrical Control Limited | Manufacturing | 2014 |
| Technique Anglaise Limited | Professional & scientific | 1999 |
| Terra Amet Ltd | Real estate | 2020 |
| Tetcott Energy Limited | Energy | 2014 |
| TFL Projects Limited | Professional & scientific | 2026 |
| THE Agile Coach House Ltd | Information & communication | 2015 |
| THE Cornish Farmhouse Bacon Co Ltd | Wholesale & retail | 2013 |
| THE Cornish JAR Ltd | Manufacturing | 2024 |
| THE Financial Wave Ltd | Information & communication | 2017 |
| THE Gardens Treatment Works (Brandis Corner) Ltd | Water & waste | 2002 |
| THE Hill Bakery Ltd | Wholesale & retail | 2014 |
| THE Holsworthy Foot Health Clinic Ltd | Health & social care | 2017 |
| THE Honest Manager Ltd | Professional & scientific | 2022 |
| THE Magic Beatbox Ltd | Arts & recreation | 2022 |
| THE Molesworth Ltd | Hospitality | 2026 |
| THE Old Chapel Management Company (Holsworthy) Limited | Households | 2019 |
| THE Old Garage Management Company Ltd | Households | 2019 |
| THE Old School House Management Company (Holsworthy) Limited | Households | 2025 |
| THE Palm Club Limited | Other services | 2021 |
| THE Sage Apothecary Limited | Wholesale & retail | 2018 |
| THE UK Windsurfing Association | Arts & recreation | 1982 |
| THE ZEN Jungle Retreat Limited | Hospitality | 2020 |
| Theclinic (SW) Limited | Health & social care | 2017 |
| Thesalon (SW) Ltd | Health & social care | 2017 |
| Thornbury Holiday Park Ltd | Hospitality | 2016 |
| Thorne Manor Day Nursery (Holsworthy) Limited | Education | 2012 |
| Thuborough Farms Ltd | Agriculture & fishing | 2015 |
| Tiderock Ltd | Agriculture & fishing | 2017 |
| Tile Inspirations Limited | Construction | 2005 |
| Tofani Global Logistics Ltd | Transport & logistics | 2026 |
| Torridge Pet Cremation Limited | Other services | 2023 |
| Tradeglaze (Devon) Limited | | 1985 |
| Trailer Management Services Limited | Wholesale & retail | 1997 |
| Treburley Physio Limited | Other services | 2019 |
| Treeworthy Services Ltd | Agriculture & fishing | 2023 |
| Trewin Design Architects Limited | Professional & scientific | 2013 |
| Trigon Farm Ltd | Agriculture & fishing | 2020 |
| Turtle Card Group Ltd | Wholesale & retail | 2023 |
| Two for Joy Bridal Ltd | Wholesale & retail | 2023 |
| Unite Safety Consultancy Ltd | Health & social care | 2024 |
| Uptonblue Properties Limited | Real estate | 1999 |
| VIA5D Ltd | Information & communication | 2020 |
| Vincent Developments (Devon) Ltd | Construction | 2023 |
| VITRINEN24 Limited | Wholesale & retail | 2010 |
| Vizikidz Ltd | Wholesale & retail | 2025 |
| Voxpop Financial Limited | Administrative & support | 2018 |
| W Sanders & Sons Ltd | Wholesale & retail | 2003 |
| WAJ Events Ltd | Administrative & support | 2020 |
| Wedbuild Ltd | Construction | 2003 |
| Weekstone Lakes Estate Ltd | Information & communication | 2001 |
| Wessex Pantry Limited | Manufacturing | 2004 |
| West Country Concrete Products Limited | Manufacturing | 2009 |
| West Country Pets Ltd | Wholesale & retail | 2022 |
| Westonbirt Water Services Ltd | Water & waste | 2025 |
| Whippet Hire Ltd | Administrative & support | 2025 |