| Cyber Gamer Limited | Information & communication | 2003 |
| Cysa Online Limited | Wholesale & retail | 2023 |
| D & S Lettings Limited | Real estate | 2023 |
| D B W Limited | Wholesale & retail | 2002 |
| D Haigh & Co Ltd | Construction | 2009 |
| D I T Consultancy Limited | Other services | 2005 |
| D J Allen Roofing Limited | Construction | 1990 |
| D Lindley & Sons Electrical Limited | Construction | 2014 |
| D&L S Developments Limited | Real estate | 2016 |
| D. J. Allen (Builders) Limited | Construction | 1993 |
| D.S.M. Textiles Limited | Wholesale & retail | 1998 |
| D27 Vinyl Wrapping Ltd | Manufacturing | 2021 |
| D4S Solutions Ltd | Information & communication | 2021 |
| Dagnall International Trading Limited | Professional & scientific | 1987 |
| Daisy LEA Events Ltd | Arts & recreation | 2022 |
| Dale Tool Co.Limited | Real estate | 1947 |
| Dalton Health Ltd | Health & social care | 2014 |
| Danelaw Coffee (Retail) Ltd | Hospitality | 2024 |
| Danelaw Coffee Roasting Ltd | Manufacturing | 2022 |
| Danthri Limited | Hospitality | 2023 |
| Dark Peak Limited | Professional & scientific | 2021 |
| Darnley Close 1960 Limited | Extraterritorial | 2013 |
| Dartura Limited | Construction | 2010 |
| Data Forge Business Solutions Limited | Information & communication | 2024 |
| Dathan Tool & Gauge Co Limited | Manufacturing | 1964 |
| Datumland Limited | Professional & scientific | 1986 |
| David Brown Tractor Club Limited | Other services | 1997 |
| David Conway in Focus Limited | Professional & scientific | 2014 |
| David Hall Innovation Ltd | Professional & scientific | 2024 |
| David Tobin Limited | Information & communication | 2011 |
| Davidson Investment Group Ltd | Financial services | 2025 |
| Dawespropertyinvestment Ltd | Real estate | 2023 |
| Dawson & Others Consultancy Limited | Professional & scientific | 2010 |
| DB Architects (Yorkshire) Ltd | Professional & scientific | 2005 |
| DBL Transport & Storage Ltd | Transport & logistics | 2014 |
| DCS Huddersfield Ltd | Administrative & support | 2023 |
| Deacon Commercial Limited | Other services | 2023 |
| Deadwax Music Ltd | Arts & recreation | 2024 |
| Deanhouse Electrical Limited | Construction | 2023 |
| Deanhouse Group Limited | Financial services | 2022 |
| Deanhouse Interiors Limited | Construction | 2008 |
| Deanhouse Joinery Limited | Construction | 2023 |
| Dear Japan Ltd | Wholesale & retail | 2025 |
| Deer Hill Consulting Limited | Professional & scientific | 2023 |
| Delatorra Ltd | Professional & scientific | 2010 |
| Delgirl Beauty Ltd | Wholesale & retail | 2017 |
| DELILAURENT39 Ltd | Hospitality | 2017 |
| Della-Verde Transport Ltd | Transport & logistics | 2022 |
| Dempsey Civils Limited | Construction | 2014 |
| Denby Project Services Ltd | Professional & scientific | 2013 |
| Denston Limited | Real estate | 2013 |
| Dentistry at Holme Limited | Health & social care | 2020 |
| Design Junkie Limited | Information & communication | 1999 |
| Designed by Insight Limited | Arts & recreation | 2009 |
| Designs by MD Limited | Real estate | 2019 |
| Deveron Holdings Limited | Real estate | 2026 |
| Devour Limited | Hospitality | 2016 |
| DFL Events Limited | Information & communication | 2019 |
| DH Large Ltd | Information & communication | 2014 |
| Dhcda Limited | Health & social care | 2025 |
| Diane Andrew Life Coach Limited | Administrative & support | 2020 |
| Dickinson Property Limited | Real estate | 2024 |
| Digital Twin AI Ltd | Information & communication | 2025 |
| Dilligaf Workshop Limited | Wholesale & retail | 2023 |
| Dine-Out Restaurant Limited | Real estate | 2003 |
| Direct Carpet Co (Brighouse) Limited | Wholesale & retail | 2010 |
| Direct Driver Ltd | Transport & logistics | 2018 |
| DJ Activities Ltd | Arts & recreation | 2026 |
| DJC Technical Management Services Ltd | Professional & scientific | 2024 |
| DK Print Limited | Manufacturing | 2004 |
| DN Enterprise Ltd | Manufacturing | 2026 |
| DNM Plumbing & Heating Services Limited | Manufacturing | 2003 |
| Dolphin Heating Ltd | Professional & scientific | 2021 |
| Donaldson's Farm and Equine Ltd | Professional & scientific | 2021 |
| DOT FOX Limited | Professional & scientific | 2026 |
| Doted Ltd | Construction | 2023 |
| Double Trouble Publishing Limited | Information & communication | 2004 |
| Doublevision Windows and Composite Doors Specialist Halifax Ltd | Construction | 2010 |
| DR a Saghir Ltd | Health & social care | 2017 |
| Drain Equip Limited | Wholesale & retail | 2013 |
| Drakes Yard Huddersfield Ltd | Real estate | 2015 |
| Dream to Dream Ltd | Administrative & support | 2025 |
| Drill ROD & Piling Casing UK Limited | Other services | 2023 |
| Dsem Properties Ltd | Real estate | 2019 |
| DT Healthcare Consultancy Limited | Health & social care | 2018 |
| Dynamic K3M Limited | Real estate | 2021 |
| Délicieux Chocolat Ltd | Manufacturing | 2021 |
| E D S Haulage Limited | Transport & logistics | 2003 |
| Eadon Green Limited | Manufacturing | 2016 |
| EAO Medical Ltd | Health & social care | 2020 |
| Earlbuy Limited | Professional & scientific | 1990 |
| Earnshaw KAY (Holmfirth) LLP | | 2009 |
| Earnshaw KAY (Huddersfield) LLP | | 2009 |
| Earnshaw Securities Limited | Real estate | 2009 |
| Earthtest Ltd. | Professional & scientific | 1997 |
| Eastart Holdings Limited | Financial services | 2018 |
| Eastart Limited | Real estate | 1997 |
| Easton Unit 11 Limited | Real estate | 2017 |
| ECB Property Developments Limited | Construction | 2026 |
| Eckersley Valve Engineering Ltd | Professional & scientific | 2025 |