| SC E&M Ltd | Construction | 2016 |
| Scimitar Homes Limited | Construction | 2008 |
| Scorchini's Pizzeria Ltd | Hospitality | 2023 |
| Scrap Local Ltd | Mining & quarrying | 2019 |
| SDB Security Systems Ltd | Administrative & support | 2012 |
| Seckington and Whitehead 2008 Limited | Construction | 2007 |
| Secure Weee Recycling Ltd | Water & waste | 2012 |
| Semilliam Limited | Professional & scientific | 2007 |
| Sentinel Trading Group Limited | Wholesale & retail | 2019 |
| Serenade Windows by Design Limited | Construction | 1996 |
| Servacus Limited | Information & communication | 2021 |
| SET in Time Ltd | Construction | 2009 |
| SEV7NS Ltd | Hospitality | 2019 |
| Seven Ports Communications Limited | Information & communication | 2015 |
| SHA Environmental Limited | Professional & scientific | 2012 |
| Shilling Hill Drylining Limited | Construction | 2016 |
| Shooting Star Entertainments (Maidstone) Ltd | Arts & recreation | 2014 |
| Shopfit UK (Hull) Limited | Manufacturing | 2000 |
| Shore Groundworks Limited | Construction | 2018 |
| Shoreditch Consulting Group Ltd | Information & communication | 2015 |
| Showtour Events Limited | Administrative & support | 2015 |
| Showtour Ticketing Limited | Administrative & support | 2020 |
| Simply Contracts Limited | Wholesale & retail | 2007 |
| Simply Fish (Fleetwood) Limited | Wholesale & retail | 2019 |
| SIR Juan Ltd | Manufacturing | 2019 |
| Sirius Packaging Solutions Limited | Manufacturing | 2020 |
| Sista Trade Windows Ltd | Wholesale & retail | 2021 |
| SK & SS Ltd | Information & communication | 2018 |
| Sling Studio Ltd | Administrative & support | 2013 |
| Slough Exotic Foods Ltd | Wholesale & retail | 2019 |
| Smile Property Development Limited | Construction | 2011 |
| Smith Fencing Contractors Limited | Wholesale & retail | 2018 |
| SMJ Utilities Ltd | Construction | 2015 |
| Smok'D Pubs Ltd | Hospitality | 2019 |
| Solidwoodshopuk Ltd | Manufacturing | 2022 |
| South Coast Science Limited | Professional & scientific | 2016 |
| South Style Ltd | Other services | 2008 |
| Southwood Windows Limited | Construction | 2017 |
| Spacecorp Ltd | Information & communication | 2018 |
| Specialised Property Solutions Ltd | Other services | 2018 |
| Sphene Systems Limited | Professional & scientific | 2006 |
| Spire Scaffolding Limited | Construction | 2011 |
| Spring Eco Home Ltd | Other services | 2016 |
| SPT Compliance Limited | Information & communication | 2018 |
| SQUARE1 Limited | Wholesale & retail | 2009 |
| SR B2B Media Ltd | Other services | 2015 |
| SSG Rigging Services Ltd | Information & communication | 2019 |
| Staffordshire Weight Loss Clinic Limited | Health & social care | 2016 |
| Stand Sure Composites Ltd | Manufacturing | 2013 |
| Sterling Construction and Renewables Ltd | Construction | 2017 |
| Sterren Ltd | Transport & logistics | 2020 |
| Stones Gym Limited | Arts & recreation | 2011 |
| Storybook Weddings Limited | Professional & scientific | 2004 |
| Straco Recruitment Limited | Administrative & support | 1999 |
| Stretton Brickwork Ltd | Construction | 2016 |
| Strk Ltd | Health & social care | 2019 |
| Strong Removals & Storage Ltd | Transport & logistics | 2019 |
| Stuart Graham Travel Counsellor Ltd | Administrative & support | 2018 |
| Studio Yelle Ltd | Wholesale & retail | 2020 |
| Style Agent Ltd | Wholesale & retail | 2016 |
| Such Home Limited | Wholesale & retail | 2011 |
| SUK Patel Ltd | Real estate | 2018 |
| Sukhdeep Transport Ltd | Transport & logistics | 2018 |
| Superlative Recruitment Limited | Professional & scientific | 2014 |
| Supplies Shop Ltd | Wholesale & retail | 2022 |
| Supremefm Ltd | Other services | 2019 |
| Surveillance, Alarm, Fire & Entry Systems Limited | Administrative & support | 2013 |
| Sussex Contractors Ltd | Construction | 2019 |
| Sussex Stoneworx Limited | Administrative & support | 2011 |
| Sweet Bar MIX Limited | Wholesale & retail | 2022 |
| Swift Construction Durham Limited | Construction | 2014 |
| Swindon Wood Supply Ltd | Manufacturing | 2013 |
| Sycamore Hospitality Limited | Hospitality | 2024 |
| Sylva Ltd | Financial services | 2015 |
| Sync Sourcing (U.K) Limited | Wholesale & retail | 2013 |
| Synergy Southwest Ltd | Construction | 2018 |
| Synthetic Pro Audio Limited | Wholesale & retail | 2017 |
| T D J Builders Limited | Construction | 2018 |
| T J R Scaffolding Ltd | Construction | 2008 |
| T T G Coaching Ltd | Education | 2022 |
| T&C Cleaning Services Limited | Administrative & support | 2021 |
| T-Space Construction Limited | Professional & scientific | 2012 |
| T.N.Q.S. Limited | Other services | 2018 |
| Tact Consulting Limited | Information & communication | 2011 |
| Tailored Recruitment Consultancy Limited | Administrative & support | 2016 |
| Tamar Care Services Southwest Ltd | Health & social care | 2018 |
| Tana Couriers Ltd | Transport & logistics | 2018 |
| Tarn Thai (UK) Ltd | Hospitality | 2009 |
| Tasnadi Services Ltd | Transport & logistics | 2018 |
| Taunton Vale Limited | Wholesale & retail | 2015 |
| Taylor Hair and Beauty Limited | Other services | 2023 |
| TBC Leisure Limited | Other services | 2020 |
| Tech-Cycle Solutions Ltd | Water & waste | 2020 |
| Techbuild Construction Partners Limited | Construction | 2012 |
| Thai Cuisine Express (Liverpool) Ltd | Hospitality | 2020 |
| Thames Spark Group Ltd | Construction | 2019 |
| THE Ace Centre-North | Professional & scientific | 2001 |
| THE Balloon Basement Ltd | Wholesale & retail | 2020 |
| THE Bark House Limited | Hospitality | 2007 |
| THE Billy Goat Barbers Ltd | Other services | 2015 |