| Samco International Limited | Manufacturing | 2006 |
| Samp Corp Ltd | Manufacturing | 2014 |
| Samwill Healthcare Equipment Limited | Wholesale & retail | 2025 |
| Sandford School of Dance LLP | | 2014 |
| Sandhu’S Properties Limited | Real estate | 2026 |
| Sandringham Grove Management Company Limited | Real estate | 2011 |
| Sands Asset Holdings Ltd | Real estate | 2025 |
| Sands of Suffolk Ltd | Real estate | 2025 |
| Sandy K Salon Ltd | Other services | 2017 |
| Sanibell (UK) Ltd | Wholesale & retail | 2025 |
| Sanj Consulting Ltd | Information & communication | 2018 |
| Sankara Imports UK Limited | Wholesale & retail | 2019 |
| Santoro Blue Limited | Professional & scientific | 2015 |
| Santé Studio Ltd | Arts & recreation | 2025 |
| Sarah Custance Ltd | Arts & recreation | 2023 |
| Sarah Maylin Events Limited | Wholesale & retail | 2022 |
| Sarah Maylin Flowers Limited | Wholesale & retail | 2022 |
| Saralasparks Ltd | Manufacturing | 2024 |
| SAS Locksmiths Ltd | Administrative & support | 2021 |
| Satkol Medical Consultancy Ltd | Professional & scientific | 2025 |
| Saucepan Ltd | Manufacturing | 2020 |
| Saunders Automotive Group Limited | Financial services | 2018 |
| Saunders Garage (Stotfold) Limited | Wholesale & retail | 2021 |
| Saunders Garage Limited | Administrative & support | 2009 |
| Saunders Recovery Limited | Extraterritorial | 2022 |
| Sausage and Gobbler Productions Limited | Arts & recreation | 2017 |
| Sava Properties Limited | Real estate | 2022 |
| Savage & Rudge Solutions Limited | Manufacturing | 2016 |
| Savrocco Limited | Professional & scientific | 2025 |
| Savvi Travel Hitchin Ltd | Administrative & support | 2015 |
| Savvy Photography Limited | Professional & scientific | 2019 |
| SAW Property Consultants Ltd | Real estate | 2026 |
| SAY What Designs Ltd | Professional & scientific | 2023 |
| SAY When Film Construction Ltd | Construction | 2020 |
| Saywood Studio Ltd | Wholesale & retail | 2020 |
| SB Electronic Engineering Ltd | Professional & scientific | 2020 |
| SB Stotfold Ltd | Other services | 2022 |
| Sbarberinggroup Ltd | Other services | 2025 |
| SBS Storage Ltd | Transport & logistics | 2021 |
| SBX Safety Solutions Ltd | Education | 2023 |
| SC Fire Risk Consultancy Ltd | Professional & scientific | 2025 |
| SCA Insight Consulting Ltd | Information & communication | 2025 |
| Scac Developments Limited | Construction | 2026 |
| Scarf Q Limited | Financial services | 2025 |
| Scarlett Moon Limited | Information & communication | 2025 |
| SCE Properties Ltd | Real estate | 2023 |
| Schaffelaarbos UK Ltd | Manufacturing | 2020 |
| Schemely Ltd | Information & communication | 2025 |
| Schole Education Limited | Education | 2012 |
| Scholtus Petcare UK Ltd | Wholesale & retail | 2020 |
| School Transport Group Limited | Transport & logistics | 2019 |
| Schoolyard Limited | Wholesale & retail | 1994 |
| Schumacher Assets Ltd | Real estate | 2024 |
| Schwaner Consulting Ltd | Financial services | 2018 |
| Schye Construction Limited | Construction | 2018 |
| Scill Plastering Limited | Construction | 2006 |
| Scill Renders Limited | Construction | 2019 |
| Scintillium Limited | Information & communication | 2015 |
| Scope Surveys Limited | Construction | 2007 |
| Scorpio Consulting Limited | Professional & scientific | 2018 |
| Scott & Co Property Investments Limited | Real estate | 2019 |
| Scott Associates Limited Liability Partnership | | 2001 |
| Scott Briscoe Limited | Financial services | 1997 |
| Scott Family Ltd | Financial services | 2025 |
| Scotts Ground Maintenance Limited | Administrative & support | 2015 |
| SCR20 Limited | Professional & scientific | 2020 |
| Scream Laboratories Ltd | Manufacturing | 2018 |
| Scrubbish Ltd | Administrative & support | 2016 |
| SDL Construction Ltd | Manufacturing | 2007 |
| SDL Solutions Limited | Professional & scientific | 2009 |
| Sdlk Property Ltd | Real estate | 2022 |
| Sdruh Cram Consulting Limited | Information & communication | 2017 |
| Seabiscuit Finadvisory Limited | Professional & scientific | 2025 |
| Seaby Estates Ltd | Real estate | 2023 |
| Seaby Homes Ltd | Real estate | 2024 |
| Sealed With a Gift Limited | Wholesale & retail | 2018 |
| Seascape Croyde Ltd | Hospitality | 2018 |
| Seaton Properties Limited | Real estate | 1996 |
| Seaview Cleaning Services Ltd | Administrative & support | 2024 |
| Sebjan Investments Ltd | Real estate | 2023 |
| Secret Scent Box Limited | Wholesale & retail | 2018 |
| Secrets by Sorellas Limited | Wholesale & retail | 2023 |
| Secured Transport Logistics Ltd | Transport & logistics | 2021 |
| SECURITYSYSTEMS4U Ltd | Administrative & support | 2011 |
| Sedhyam Farm UK Ltd | Agriculture & fishing | 2026 |
| Segs Plant Services Ltd | Wholesale & retail | 2019 |
| Seima Construction Limited | Construction | 1999 |
| Self Studios Limited | Professional & scientific | 2016 |
| Sellors & Lettors Limited | Real estate | 2009 |
| Send.Ai Innovation Ltd | Information & communication | 2025 |
| Senj Ltd | Transport & logistics | 2019 |
| Sensa Taste Ltd | Hospitality | 2026 |
| Sensinuity Ltd | Professional & scientific | 2025 |
| Sentryian Ltd | Information & communication | 2023 |
| Sequence of Events Ltd | Administrative & support | 2013 |
| Serecena Eleven Limited | Administrative & support | 2005 |
| Serenity Media Limited | Wholesale & retail | 2019 |
| Servetus Associates Limited | Professional & scientific | 2009 |
| Setting OUT Solutions Limited | Construction | 2024 |
| Seva Property Ltd | Real estate | 2019 |