| Sapro Europe Ltd | Wholesale & retail | 2022 |
| Sarah Willoughby Limited | Information & communication | 2012 |
| Sash Renovations Limited | Construction | 2007 |
| Sask Optics Limited | Health & social care | 2005 |
| Saunders Plant Limited | Extraterritorial | 2014 |
| Sav-Tech Holdings Limited | Financial services | 2018 |
| Savage Autos Ltd | Extraterritorial | 2024 |
| Savage Marine Holdings Limited | Financial services | 2021 |
| Savage Marine Ltd | Manufacturing | 2000 |
| Saxon Fitness Trading Ltd | Arts & recreation | 2023 |
| SB Precision Engineers Ltd | Manufacturing | 2020 |
| SB14 Media Ltd | Professional & scientific | 2019 |
| Scalford Road Melton Management Company Limited | Households | 2016 |
| Scalpease Ltd | Wholesale & retail | 2025 |
| Scarco Property Ltd | Real estate | 2022 |
| SCM Retail Ltd | Wholesale & retail | 2026 |
| Scout Financial Services Limited | Financial services | 2015 |
| SCR21 Limited | Information & communication | 2021 |
| Scrivins & Co Ltd | Real estate | 2019 |
| SDP Property Holdings Ltd | Real estate | 2018 |
| Sea-Band Holdings Hinckley Limited | Financial services | 2026 |
| Sea-Band Holdings Newport Limited | Financial services | 2026 |
| Sea-Band Limited | Wholesale & retail | 1999 |
| Seagrave Road Sileby Management Company Limited | Households | 2021 |
| Second Wave Plastics Ltd | Manufacturing | 2025 |
| Secret Garden Hive Ltd | Hospitality | 2023 |
| Securemed Logistics Ltd | Transport & logistics | 2025 |
| Sennes Ltd | Health & social care | 2023 |
| Sense of the Herd CIC | Education | 2024 |
| Sentido Marketing Limited | Professional & scientific | 2016 |
| Serenity Glamping Ltd | Hospitality | 2024 |
| Serious Consultancy Services Limited | Professional & scientific | 2023 |
| Service 2 Transport Ltd | Construction | 2010 |
| Servicedstay Solutions Ltd | Real estate | 2025 |
| SET to LET Properties Ltd | Real estate | 2014 |
| Seven Business Consultants Ltd | Professional & scientific | 2014 |
| Seven PE Kent Ltd | Construction | 2025 |
| SG Imagineering Ltd | Other services | 2014 |
| Shalom One Ltd | Transport & logistics | 2018 |
| Shaman Tech Solutions Ltd | Information & communication | 2025 |
| Shape Technologies Group UK Ltd | Wholesale & retail | 1998 |
| Shapecraft Trading Limited | Manufacturing | 2017 |
| Shardana Deep Cleaning Ltd | Administrative & support | 2026 |
| Sharnford Arms PUB Ltd | Hospitality | 2024 |
| Shaun Brown Limited | Professional & scientific | 2021 |
| Shaw Installations Limited | Professional & scientific | 2019 |
| Shdw Label Ltd | Wholesale & retail | 2025 |
| Sheila O'Neill Coaching Ltd | Health & social care | 2020 |
| Shepherd Electrical Contractors Ltd | Construction | 2019 |
| Sheridan Homes Developments Limited | Real estate | 2024 |
| Sherwood Mews Management Company Limited | Households | 2010 |
| Shield of Faith Meeting Centre Limited | Hospitality | 2023 |
| Shields Health & Safety Limited | Administrative & support | 2024 |
| Shilton Cast Iron & Welding Limited | Manufacturing | 2005 |
| Shine Inside OUT Limited | Information & communication | 2017 |
| Shinemel Limited | Real estate | 1989 |
| Shirley Computer Services Limited | Information & communication | 1998 |
| Shish Restaurant Ltd | Hospitality | 2025 |
| Shopdo Limited | Administrative & support | 2019 |
| Shoptekuk Ltd | Wholesale & retail | 2010 |
| Short Cuts TV Ltd | Arts & recreation | 2011 |
| Shout About IT Media Ltd | Professional & scientific | 2023 |
| Shower Outlet Limited | Wholesale & retail | 2013 |
| Showpax Conference Services Limited | Transport & logistics | 2007 |
| Showstoppers Entertainment Ltd | Arts & recreation | 2024 |
| Shree Krushna Corp Ltd | Wholesale & retail | 2022 |
| Shree Yamunajia Ltd | Wholesale & retail | 2025 |
| SHU Investments Limited | Financial services | 2022 |
| Siddle Builders Coventry Ltd | Construction | 2022 |
| Sigma Components (Farnborough) Limited | Manufacturing | 2007 |
| Sigma Components Holdings Limited | Financial services | 2016 |
| Sigma Components Limited | Financial services | 2016 |
| Sigma Components Midco 1 Limited | Financial services | 2016 |
| Sigma Components Midco 2 Limited | Financial services | 2016 |
| Sigma Precision Components Limited | Professional & scientific | 2004 |
| Sigma Precision Components UK Limited | Manufacturing | 1963 |
| Signature DIY Ltd | Wholesale & retail | 2008 |
| Signature Fabrications Ltd | Manufacturing | 2017 |
| Silva Engineering Solutions Ltd | Construction | 2026 |
| Simon Cheshire Planning Ltd | Professional & scientific | 2014 |
| Simon Thomas Fire Ltd | Extraterritorial | 2025 |
| Simply Bathrooms (Leicestershire) Limited | Extraterritorial | 2014 |
| Simply Bathrooms (Midlands) Limited | Extraterritorial | 2014 |
| Simply Bathrooms (Warwickshire) Limited | Extraterritorial | 2014 |
| Siobhan Fagan Ltd | Professional & scientific | 2024 |
| Siroke Investments Limited | Extraterritorial | 2020 |
| Sirs Business Ltd | Hospitality | 2021 |
| SIX Seven Warwickshire Limited | Real estate | 2026 |
| SJO Developments Ltd | Real estate | 2026 |
| SJW Support Limited | Information & communication | 2014 |
| Sketchley House Clearance Services Ltd | Water & waste | 2023 |
| Skincast Medical Limited | Other services | 2023 |
| Sklc Property Ltd | Real estate | 2023 |
| Skllin Limited | Information & communication | 2023 |
| Skyb Company Limited | Other services | 2021 |
| Sleep Sentinel Limited | Manufacturing | 2017 |
| SLM Fitness & Health Limited | Arts & recreation | 1999 |
| SLM Food & Beverage Limited | Hospitality | 1999 |
| Smarday Ltd | Financial services | 2024 |
| Smart Dent Solutions Ltd | Wholesale & retail | 2025 |