| Sudha Property Group Ltd | Real estate | 2017 |
| Suitcase Stories Ltd | Administrative & support | 2024 |
| Suitcrown Limited | Real estate | 1981 |
| Suite-Bathrooms - Dave Spicer Ltd | Construction | 2018 |
| Sullerpoint Limited | | 1976 |
| Sullivan Entertainment Ltd | Hospitality | 2025 |
| Sult Sales Ltd | Wholesale & retail | 2025 |
| SUM Accountants Limited | Professional & scientific | 2017 |
| Sumakhf Enterprises Ltd | Wholesale & retail | 2020 |
| Sume Ltd | Professional & scientific | 2014 |
| Summer Downs Residents Management Company Limited | Households | 2005 |
| Summer International Group Ltd | Education | 2024 |
| Summerhill Consulting Limited | Professional & scientific | 2014 |
| Summerleys Business Centre (Management) Limited | Professional & scientific | 2018 |
| Summit Logistics Ltd | Transport & logistics | 2024 |
| Summit Solutions Ltd | Construction | 2021 |
| Sun & Sirius Limited | Education | 2025 |
| Sun Sea Properties Ltd | Real estate | 2021 |
| Sun Villa Holiday Limited | Hospitality | 2004 |
| Sunar Moyna Ltd | Hospitality | 2025 |
| Sunbeam Control Ltd | Information & communication | 2026 |
| Sunbench Limited | Manufacturing | 1988 |
| Sunfire Property Limited | Real estate | 2019 |
| Sunflower Strategies Ltd | Professional & scientific | 2015 |
| Sunlight Forest Ltd | Manufacturing | 2021 |
| Sunny Trans Ltd | Transport & logistics | 2025 |
| Sunrise Ascend Ltd | Administrative & support | 2025 |
| Sunrise Wills and Probate Ltd | Professional & scientific | 2020 |
| Sunset RUM UK Ltd | Wholesale & retail | 2025 |
| Sunshine Engineering Ltd | Manufacturing | 2021 |
| Sunvista Property Limited | Real estate | 2018 |
| Super & Prestige Motor Services Ltd | Transport & logistics | 2018 |
| Super Reel Travel Limited | Information & communication | 2024 |
| Super Specialist Cars Ltd | Wholesale & retail | 2024 |
| Supercasino Limited | Extraterritorial | 2006 |
| Superior Startups Limited | Professional & scientific | 2016 |
| Superstes Holdings Limited | Professional & scientific | 2025 |
| Supplier Bridge Ltd | Professional & scientific | 2025 |
| Supplies Web Group Limited | Administrative & support | 2009 |
| Supplies Web Limited | Wholesale & retail | 2005 |
| Supply I.T Ltd | Information & communication | 2025 |
| Support Hive AI Ltd | Information & communication | 2026 |
| Supreme Bifolds Ltd | Construction | 2022 |
| Supreme Joy Consulting Private Limited | Information & communication | 2018 |
| Sureeta Music Limited | Arts & recreation | 2023 |
| Surelectric Limited | Construction | 2006 |
| Surging UK Limited | Wholesale & retail | 2025 |
| Suro Enterprises Limited | Wholesale & retail | 2023 |
| Surrey Psychologist Ltd | Health & social care | 2026 |
| Surrey Smartfix Limited | Wholesale & retail | 2021 |
| Susan Ing-Simmons Limited | Households | 2022 |
| Susela and SON Ltd | Hospitality | 2025 |
| Sushi Wycombe Limited | Hospitality | 2022 |
| Sustainable Grid Tech Ltd | Information & communication | 2024 |
| Suter Lighting Limited | Other services | 2017 |
| Sutherland Compliance Ltd | Professional & scientific | 2023 |
| Sutherland Consulting International Ltd | Administrative & support | 2025 |
| Suzhou Bestar Blow Molding Machinery Co., Ltd Limited | Wholesale & retail | 2024 |
| SV Performance Limited | Wholesale & retail | 2015 |
| SV Properties Group Limited | Real estate | 2019 |
| SW32 Limited | Professional & scientific | 2004 |
| Swallow Properties Ltd | Extraterritorial | 2016 |
| Swallow Property Investments Limited | Administrative & support | 2007 |
| Swan Independent Housing Limited | Hospitality | 2023 |
| Swarthmore Land Ltd | Construction | 2026 |
| Swazi Consulting Ltd | Professional & scientific | 2025 |
| SWC Consultants Limited | Information & communication | 2024 |
| Sweet Spots Records Ltd | Extraterritorial | 2018 |
| Sweet Stuff Cafe Limited | Wholesale & retail | 2020 |
| SWF Events Consulting Limited | Arts & recreation | 2009 |
| Swift Marketing Consultants Limited | Professional & scientific | 2024 |
| Swift Minibus Hire Ltd | Information & communication | 2017 |
| Swift Shop HW Ltd | Wholesale & retail | 2024 |
| Swift Tyre Services Limited | Wholesale & retail | 1997 |
| Swift Way Ltd | Wholesale & retail | 2025 |
| Swissci Limited | Manufacturing | 2014 |
| Switch Centre Ltd | Professional & scientific | 2018 |
| Switch Consultancy Limited | Information & communication | 2015 |
| Switch Health Limited | Financial services | 2013 |
| Switch Lanes CIC | Administrative & support | 2024 |
| SWR Smash & Grab Limited | Manufacturing | 2006 |
| Swrnewstar Limited | Water & waste | 2017 |
| Swsm Group Limited | Wholesale & retail | 2025 |
| Swtlabs Limited | Information & communication | 2019 |
| Swyft Home Limited | Wholesale & retail | 2011 |
| SWZ FBA Ltd | Wholesale & retail | 2022 |
| SY Tutoring Ltd | Education | 2023 |
| Syal Holdings Ltd | Real estate | 2021 |
| Sybaritic Limited | Wholesale & retail | 2010 |
| Sycamore Court (High Wycombe) Residents Association Limited | Households | 1983 |
| Syclonx Limited | Information & communication | 2023 |
| Sygnip Ltd | Information & communication | 2023 |
| Sygnus Office Partnership Limited | Wholesale & retail | 1994 |
| Sylvester Decorating Ltd | Construction | 2017 |
| Sylvia Mbemba Consulting Ltd | Professional & scientific | 2025 |
| Sylviana Ltd | Transport & logistics | 2014 |
| SYM Care Ltd | Health & social care | 2021 |
| SYM Construction Ltd | Construction | 2024 |
| Symbius Urban Works Limited | Construction | 2015 |
| Syml Solutions Limited | Information & communication | 2021 |