| Spurlands Studio Ltd | Other services | 2025 |
| SPV Ventures Ltd | Hospitality | 2023 |
| SQF Group Ltd | Administrative & support | 2025 |
| SQF Retail Ltd | Administrative & support | 2025 |
| Squeaky Ninjas Ltd | Administrative & support | 2025 |
| SR Cleaners Services Ltd | Administrative & support | 2025 |
| SR Design Limited | Professional & scientific | 2023 |
| SR Plumbing and Heating Ltd | Construction | 2025 |
| SR77 Limited | Information & communication | 2018 |
| Sravanti Properties Ltd | Real estate | 2023 |
| SRD Homes Ltd | Real estate | 2025 |
| Sreelahari Solutions Ltd | Information & communication | 2016 |
| SRI Gnan IT Solutions Limited | Information & communication | 2018 |
| SRI Kaus Limited | Health & social care | 2013 |
| Srias Ltd | Real estate | 2024 |
| SRM Digital Limited | Information & communication | 2020 |
| SRQ Companies Ltd | Information & communication | 2022 |
| SRS Flat Roof Centre Ltd | Construction | 2018 |
| Srshaw Ltd | Households | 2024 |
| SS 82 Logistics Limited | Transport & logistics | 2018 |
| SS MED Ltd | Health & social care | 2024 |
| SS Wellbeing Ltd | Other services | 2022 |
| SS1 Engineering Ltd | Manufacturing | 2026 |
| SSA Westend Property Ltd | Extraterritorial | 2020 |
| SSG Asset and Holdings Limited | Real estate | 2026 |
| SSK Velan Ltd | Wholesale & retail | 2025 |
| SSM & AM Ltd | Real estate | 2014 |
| SSM Coaching Enterprise Limited | Arts & recreation | 2021 |
| Sspa Technologies Ltd | Information & communication | 2021 |
| SSR Law Ltd | Professional & scientific | 2023 |
| SSS Cakes Limited | Wholesale & retail | 2024 |
| ST Accounting Holdings Limited | Financial services | 2025 |
| ST Crispin Area H Management Company Limited | Extraterritorial | 2006 |
| ST Dunstans Apartment Management Company Limited | Extraterritorial | 2013 |
| ST John Smith & Co (Hampton) Limited | Extraterritorial | 2005 |
| ST John Smith & Co (London) Ltd | Extraterritorial | 2010 |
| ST John Smith & Co Limited | Professional & scientific | 1986 |
| ST John's Lodge Residents Management Company Limited | Real estate | 2015 |
| ST Rose Solutions Limited | Wholesale & retail | 2011 |
| ST Wycombe Ltd | Hospitality | 2026 |
| ST. John Publishing Limited | Information & communication | 1985 |
| ST. Katharine Haven Limited | Extraterritorial | 1973 |
| St.Katharine by the Tower Limited | Extraterritorial | 1971 |
| Staash Enterprises Ltd | Hospitality | 2018 |
| Stacksquad Ltd | Information & communication | 2021 |
| Stad Astra Ltd | Professional & scientific | 2019 |
| Staffbenefits Limited | Administrative & support | 2005 |
| Staffield Ltd | Wholesale & retail | 2004 |
| Stafford Pharma Limited | Wholesale & retail | 2024 |
| STAGE17 Designs Ltd | Arts & recreation | 2018 |
| Stanchef Ltd | Hospitality | 2019 |
| Stand-Up for Empowerment Limited | Professional & scientific | 2015 |
| Standardair Limited | Wholesale & retail | 1996 |
| Stanikowski Limited | Administrative & support | 2003 |
| Stanley Homes Limited | Construction | 1971 |
| Stanley Walsh Ltd | Arts & recreation | 2024 |
| Star & Garter Property Limited | Construction | 2010 |
| Star Bricks Developments Limited | Construction | 2025 |
| Star Hualage Ltd | Transport & logistics | 2025 |
| Star Images Limited | Other services | 1997 |
| Star QA Solutions Ltd | Information & communication | 2017 |
| Starc Developments Ltd | Real estate | 2025 |
| Stark Accounts Ltd | Professional & scientific | 2026 |
| Starlet Building Ltd | Construction | 2011 |
| Starlife Properties Ltd | Construction | 2019 |
| Starling Health Group Ltd | Professional & scientific | 2025 |
| Starstruct Ltd | Professional & scientific | 2025 |
| Start a Company Limited | Administrative & support | 2026 |
| Statistical BEE Ltd | Professional & scientific | 2024 |
| Stature Vehicle Sales Ltd | Wholesale & retail | 2024 |
| Stawi Limited | Real estate | 2011 |
| Stay Connected (HW) Ltd | Administrative & support | 2019 |
| Stay DRY and Warm ALL Under One Roof Limited | Construction | 2023 |
| Stay DRY Extensions Limited | Construction | 2025 |
| Stay Health Ltd | Manufacturing | 2026 |
| Stay Signed Limited | Professional & scientific | 2023 |
| Stay Warm (HW) Limited | Construction | 2018 |
| Stay-Dry Roofing High Wycombe Ltd | Construction | 2018 |
| Staydry Roofing and Guttering Ltd | Construction | 2023 |
| Stayforever Limited | Real estate | 2020 |
| Stayinfront (UK) Limited | Information & communication | 1997 |
| Stayinfront RDI Limited | Professional & scientific | 2003 |
| Staying Wild Ltd | Manufacturing | 2022 |
| Stayinn Relocation Experts Limited | Hospitality | 2024 |
| Staytite (Holdings) Limited | Wholesale & retail | 1979 |
| Staytite Limited | Wholesale & retail | 1978 |
| Staytite Rail Limited | Wholesale & retail | 2024 |
| STB Group Limited | Construction | 2026 |
| Steadfast Communications Limited | Professional & scientific | 2017 |
| Stealth Surface Technologies Limited | Manufacturing | 2025 |
| Steel & Style Design Ltd | Manufacturing | 2026 |
| Stefania Home and Commercial Cleaning Ltd | Construction | 2025 |
| Steffan Wayne Consulting Ltd | Professional & scientific | 2026 |
| Stella Traders Limited | Extraterritorial | 2015 |
| Stellate Consulting Limited | Information & communication | 2013 |
| Stellaton Ltd | Transport & logistics | 2012 |
| Stems of Beauty Limited | Wholesale & retail | 2012 |
| Stems Technology Ltd | Administrative & support | 2011 |
| Stephan Deco Ltd | Construction | 2021 |
| Stephen James Hunt (Carpets) Limited | Wholesale & retail | 2002 |