| Saadmahmood Ltd | Information & communication | 2024 |
| Saam Estates Limited | Real estate | 2023 |
| Saara London Ltd | Administrative & support | 2023 |
| Saarja Ltd | Real estate | 2026 |
| Sabeti Wain Aerospace Limited | Manufacturing | 1987 |
| Sabka Cleaning (UK) Ltd | Administrative & support | 2018 |
| Sabre Retail (Trading) Limited | Wholesale & retail | 2009 |
| Sabre Retail Fashion Limited | Wholesale & retail | 2012 |
| Sabre@Mosi Brands Limited | Information & communication | 2005 |
| Sacred Learning CIC | Education | 2022 |
| Saeed Motors Ltd | Wholesale & retail | 2024 |
| Saepio Solutions Limited | Information & communication | 2016 |
| Saev (Semi Autonomous Electric Vehicles) Ltd | Professional & scientific | 2024 |
| Safa Freight Ltd | Transport & logistics | 2026 |
| Safe and Certified Ltd | Professional & scientific | 2025 |
| Safe Building Ltd | Construction | 2015 |
| Safe Place Products Ltd | Professional & scientific | 2021 |
| Safe Rehab Physio Ltd | Health & social care | 2026 |
| Safe Tech Roofing Ltd | Construction | 2026 |
| Safe Way Solutions Limited | Health & social care | 2020 |
| Safeground Bookkeeping Ltd | Professional & scientific | 2025 |
| Safeguard Consulting Ltd | Administrative & support | 2016 |
| Safeshield Building & Roofing Contractors Ltd | Construction | 2024 |
| Safety CDM Ltd | Professional & scientific | 2023 |
| Safety Realm Ltd | Real estate | 2023 |
| Safra Care Ltd | Health & social care | 2023 |
| Safra Executive Ltd | Transport & logistics | 2023 |
| Sage Paths Limited | Information & communication | 2024 |
| Sahara Painting and Decorating Ltd | Construction | 2025 |
| Saheli the Label Ltd | Wholesale & retail | 2024 |
| Saheli Unity Events CIC | Health & social care | 2025 |
| Sahil Ayaan Ltd | Transport & logistics | 2019 |
| Sahota Construction Limited | Construction | 2020 |
| SAI Ashirwad IT Services Ltd | Information & communication | 2015 |
| Saichiatry Solutions Ltd | Health & social care | 2020 |
| Saif-Vision Ltd | Wholesale & retail | 2022 |
| Sailer Ltd | Other services | 2014 |
| Sailfish Media Limited | Information & communication | 2005 |
| Saint Tresa Limited | Health & social care | 2022 |
| Saints Capital Limited | Real estate | 2024 |
| Saints Favourite Ltd | Hospitality | 2026 |
| Saiz Limited | Information & communication | 2016 |
| Sakthisai Home Ltd | Real estate | 2025 |
| Salamara Limited | Information & communication | 2015 |
| Salarywise Ltd | Information & communication | 2021 |
| Salisbury Engineering Services Limited | Manufacturing | 2008 |
| Salmea Ltd | Wholesale & retail | 2018 |
| Salon on the Green Bucks Ltd | Other services | 2023 |
| Salperton Park Estate Limited | Agriculture & fishing | 1995 |
| Salperton Park House Limited | Hospitality | 1995 |
| Salt Consulting & Communications Ltd | Professional & scientific | 2009 |
| Salta DC Limited | Wholesale & retail | 2022 |
| Salvora Properties Ltd | Real estate | 2017 |
| Salvus Consulting Limited | Administrative & support | 2005 |
| SAM P Motorcycles Ltd | Wholesale & retail | 2025 |
| SAM Protective Security Ltd | Administrative & support | 2026 |
| Samagra Knowledge Services Ltd | Education | 2025 |
| Samajaharry Properties Ltd | Hospitality | 2021 |
| Samarani Limited | Information & communication | 2023 |
| Samaria Consultancy Services Ltd | Health & social care | 2013 |
| Samay Hearing Solutions Ltd | Health & social care | 2017 |
| Samo Services Limited | Professional & scientific | 2019 |
| Samphire Learning Solutions Ltd | Professional & scientific | 2014 |
| Sampson Films Limited | Administrative & support | 2010 |
| Sams Pizza (HW) Limited | Hospitality | 2016 |
| Samuel William Limited | Wholesale & retail | 2024 |
| Samvai Limited | Information & communication | 2025 |
| Sanad Developers Limited | Construction | 2025 |
| Sanctum Engineering Ltd | Professional & scientific | 2024 |
| Sandalwood Lodge Residents Management Company Limited | Households | 2016 |
| Sandbach Environmental Ltd. | Manufacturing | 1989 |
| Sandcastle Nursery Ltd | Education | 2011 |
| Sanderson Ballard Recruitment Consultants Ltd | Administrative & support | 2018 |
| Sanderson Care Limited | Hospitality | 2025 |
| Sandford Retail Limited | Extraterritorial | 2007 |
| Sandstone Holdings UK Limited | Real estate | 2016 |
| Sanfe Ltd | Wholesale & retail | 2026 |
| Sania.B Limited | Health & social care | 2023 |
| Santīre Ltd | Professional & scientific | 2022 |
| Sanu Property Limited | Real estate | 2022 |
| Sanwa Homes Ltd | Real estate | 2025 |
| Saoirse Luxury Homes Ltd | Manufacturing | 2020 |
| Sapach Limited | Financial services | 2011 |
| Sapphire Hill Law Ltd | Professional & scientific | 2022 |
| Sapphire Holdings (HW) Limited | Financial services | 2024 |
| Sapphire Property Sales and Lettings Ltd | Real estate | 2024 |
| Sapphire REY Childcare Crew Ltd | Administrative & support | 2025 |
| SAQ Commerce Limited | Wholesale & retail | 2018 |
| Sara DAW Limited | Professional & scientific | 2021 |
| Sarah Consultancy UK Ltd | Health & social care | 2026 |
| Sarah Neptune Consulting Ltd | Professional & scientific | 2018 |
| Sarala Foods Limited | Wholesale & retail | 2023 |
| Sarala Homes Limited | Real estate | 2020 |
| Sarala Technologies Limited | Information & communication | 2017 |
| Sarav Systems Limited | Information & communication | 2013 |
| Saraviv Consultancy Ltd | Information & communication | 2024 |
| Sarbie Limited | Construction | 2017 |
| Sarino Limited | Wholesale & retail | 2025 |
| Saryu Consulting Ltd | Professional & scientific | 2025 |
| Sasha Dale Ltd | Professional & scientific | 2026 |