| DFL Projects Ltd | Real estate | 2025 |
| DH Telecom Ltd | Wholesale & retail | 2017 |
| DHS Dental Practices Limited | Health & social care | 2009 |
| Diadem Business Solutions Ltd | Information & communication | 2023 |
| Diana Cowpe Limited | Wholesale & retail | 2011 |
| Diana Global (UK) Limited | Wholesale & retail | 2025 |
| Didsbury Property Group Ltd | Real estate | 2020 |
| Digbys Auto Repairs Ltd | Wholesale & retail | 2024 |
| Dilara Khanum Care and Support Services Limited | Health & social care | 2026 |
| Dimora Construction Limited | Construction | 1998 |
| Dinghe Trading Ltd | Wholesale & retail | 2026 |
| Direct Engineering Supplies Limited | Wholesale & retail | 2002 |
| Discount Stock Online Ltd | Wholesale & retail | 2020 |
| Distant Screams Events Ltd | Administrative & support | 2024 |
| Divine Grace MCR Ltd | Transport & logistics | 2025 |
| DIY Planet Ltd | Wholesale & retail | 2020 |
| DJM UK Holdings Ltd | Real estate | 2018 |
| DMA Scaff Limited | Construction | 2024 |
| Dmclean Care Ltd | Health & social care | 2023 |
| DMS Letting Ltd | Real estate | 2018 |
| DNC Motors Ltd | Wholesale & retail | 2020 |
| Domestic Appliance Services Limited | Construction | 2025 |
| Dotcom Domains Limited | Information & communication | 2005 |
| Double Vision Solutions Limited | Construction | 2024 |
| Doves Funeral Services and Carriage Masters Ltd | Other services | 2020 |
| DPT Decorators Ltd | Extraterritorial | 2018 |
| Dreampathcareservices Ltd | Health & social care | 2025 |
| Dreamworks Group Ltd | Wholesale & retail | 2025 |
| Dressers Arms Ltd | Hospitality | 2024 |
| Drip N DIP Fast Food and Desserts Limited | Hospitality | 2025 |
| Drive 4 Pass Ltd | Education | 2024 |
| DRT Online Limited | Wholesale & retail | 2004 |
| Druits Group Holdings Ltd | Financial services | 2024 |
| Druits Group Ltd | Information & communication | 2017 |
| Drwholesalers Ltd | Wholesale & retail | 2025 |
| DSG Demons Ltd | Wholesale & retail | 2020 |
| DTE Limited | Transport & logistics | 2019 |
| DTG Surveyors Ltd | Professional & scientific | 2022 |
| Duch Ltd. | Construction | 2012 |
| Duchenne NOW | Health & social care | 2012 |
| Dunkerley Bros. (1985) Limited | Real estate | 1984 |
| Duty Free Holding Limited | Financial services | 2016 |
| DV Fashion Trading Limited | Wholesale & retail | 2025 |
| DWH Flooring Limited | Construction | 2016 |
| Dylan Advocates Ltd | Professional & scientific | 2024 |
| E.Louise Aesthetics Ltd | Health & social care | 2026 |
| Easy ST Personal Training and Physiotherapy Limited | Arts & recreation | 2017 |
| Easyon Clothing Ltd | Wholesale & retail | 2019 |
| Eco-Pro Finishes Ltd | Construction | 2023 |
| Ecocleantech NW Ltd | Wholesale & retail | 2019 |
| Ecoflow GAS Concept Ltd | Construction | 2024 |
| Ecoscape UK Holdings Ltd | Financial services | 2025 |
| Ecoscape UK Ltd | Wholesale & retail | 2013 |
| Eden Beauty NW Limited | Other services | 2025 |
| Edene Limited | Wholesale & retail | 2023 |
| Edgefoot Farm Ltd | Hospitality | 2021 |
| Edstart Bolton Limited | Education | 2022 |
| Edstart Bury Ltd | Education | 2018 |
| Edstart South Manchester Limited | Education | 2024 |
| Egerton Roofing Ltd | Construction | 2023 |
| Egle Kolev Art Limited | Arts & recreation | 2023 |
| Electronomen Consulting Ltd | Construction | 2023 |
| Elevation Living Group Ltd | Real estate | 2026 |
| Eleven Twenty Stores Ltd | Wholesale & retail | 2024 |
| Elite Flips Ltd | Real estate | 2025 |
| Elite Waste Solutions Limited | Water & waste | 2025 |
| Elliott Osborne Electrical Contractor Ltd | Manufacturing | 2026 |
| Elphinstone Digital Media Limited | Information & communication | 2023 |
| Emasballoons Ltd | Manufacturing | 2023 |
| Ember Spirit Limited | Construction | 2026 |
| Emboss Tech Ltd | Administrative & support | 2026 |
| Embossing Rollers Limited | Manufacturing | 2013 |
| Emma Laye Properties Ltd | Real estate | 2025 |
| Empieor Ltd | Hospitality | 2018 |
| Endeavour Homecare Ltd | Health & social care | 2026 |
| Endoire Ltd | Wholesale & retail | 2019 |
| Englend Ltd | Real estate | 2020 |
| Enigma Logistics Ltd | Transport & logistics | 2020 |
| Ensor Mill Limited | Real estate | 2014 |
| Envair Technology Limited | Professional & scientific | 2023 |
| Envision Communications Group Limited | Information & communication | 2022 |
| EPC National Limited | Professional & scientific | 2017 |
| EPK Services Limited | Other services | 2018 |
| Equal Access Consultancy Limited | Professional & scientific | 2001 |
| Ermington Court Management Company Limited | Households | 1996 |
| Ernie Sameday Ltd | Transport & logistics | 2023 |
| Esther Apparel Ltd | Wholesale & retail | 2025 |
| ETECH247 Ltd | Manufacturing | 2021 |
| Eunich Services Limited | Health & social care | 2023 |
| Evaris Solutions Limited | Information & communication | 2012 |
| EVE Scenic Ltd | Construction | 2022 |
| Eviva Automotive Limited | Wholesale & retail | 2021 |
| Ewpropertydevelopment Ltd | Real estate | 2025 |
| Exagmite Digital Ltd | Professional & scientific | 2019 |
| Excavate NW Ltd | Construction | 2025 |
| EXCAVATE360 Limited | Construction | 2017 |
| Executive Cars Heywood Ltd | Transport & logistics | 2019 |
| Exivora Holding Ltd | Financial services | 2024 |
| Experiors (U.K.) Ltd | Construction | 2018 |
| Ezy-Rent Ltd | Agriculture & fishing | 1978 |