| Dexspec Ltd | Professional & scientific | 2022 |
| Dezaro Clearance Services Limited | Transport & logistics | 2022 |
| Dezaro Limited | Transport & logistics | 2015 |
| Dezaro Logistics Limited | Transport & logistics | 2023 |
| DF Services (Fire Protection) Ltd | Construction | 2024 |
| DH Fast Food Ltd | Hospitality | 2024 |
| Diamond Games Limited | Arts & recreation | 2010 |
| Digital Forensic Insurance Services Limited | Administrative & support | 2015 |
| Dixon Fire Sprinklers Limited | Extraterritorial | 2020 |
| Dixon Group Limited | Financial services | 2020 |
| Dixon Invests Limited | Real estate | 2020 |
| Dixon MEP Limited | Construction | 1995 |
| DMA Vehicle Solutions Ltd | Wholesale & retail | 2017 |
| DMR Renewables Limited | Information & communication | 2019 |
| Dobson Property Limited | Real estate | 2024 |
| DOC Electrical Services Ltd | Manufacturing | 2023 |
| Don’T Sleep on IT Limited | Wholesale & retail | 2026 |
| Doski Enterprises Ltd | Hospitality | 2025 |
| Double TAP Group Ltd | Hospitality | 2026 |
| Doublerhyme Limited | Arts & recreation | 2008 |
| Downing Legal Limited | Professional & scientific | 2011 |
| DP Design & Print Limited | Wholesale & retail | 2013 |
| DPS Joinery Limited | Construction | 2015 |
| Dragonfly Sign & Display Limited | Construction | 2015 |
| Drainjet East Yorkshire Ltd | Administrative & support | 2019 |
| Drydale Associates Ltd | Information & communication | 2023 |
| Dubmire Estates Limited | Financial services | 2022 |
| Duckegg Theatre Acting School Limited | Education | 2023 |
| Dunlop Garage Equipment Limited | Manufacturing | 2011 |
| DWR TV Ltd | Information & communication | 2025 |
| Dynamite Grooming Ltd | Manufacturing | 2025 |
| Dynastar Limited | Wholesale & retail | 2013 |
| Dynpos Limited | Professional & scientific | 2006 |
| E5 Coaching Ltd | Other services | 2023 |
| Eagle Drive Developments Limited | Construction | 2026 |
| Eagle Landscapes Limited | Administrative & support | 2003 |
| Easenby Enterprises Limited | Wholesale & retail | 2022 |
| East Riding Developments Limited | Construction | 2024 |
| East Riding Investment Co Limited | Hospitality | 2015 |
| East Yorkshire Print Ltd | Manufacturing | 2025 |
| East Yorkshire Roofing Limited | Construction | 2023 |
| Eastins Ltd | Hospitality | 2022 |
| Eastman Land Limited | Real estate | 2020 |
| Eastman Securities Limited | Construction | 1986 |
| Eastmount Ltd | Construction | 2021 |
| Eastyorkshire Marine Ltd | Agriculture & fishing | 2024 |
| Easy Home-Uk Limited | Wholesale & retail | 2019 |
| EC Yankeeland ( Yorkshire ) Limited | Wholesale & retail | 2025 |
| Eco Home Insulations Limited | Construction | 2025 |
| Eco Modular Group Ltd | Financial services | 2024 |
| Eco Modular Pods Ltd | Construction | 2024 |
| Eden Consultants Limited | Professional & scientific | 1998 |
| Eden Resorts Holdings Limited | Extraterritorial | 2023 |
| Eden Resorts Limited | Hospitality | 2023 |
| Edition 58 Ltd | Other services | 2010 |
| Editions by Rach Ltd | Administrative & support | 2026 |
| Editions Hair and Co Limited | Administrative & support | 2026 |
| Editions Hairdressing Ltd | Other services | 2018 |
| Edubiz Ltd | Education | 2023 |
| Efamol Limited | Wholesale & retail | 2002 |
| Effective Fitness Limited | Arts & recreation | 2017 |
| Effective Programmers Ltd | Information & communication | 2006 |
| EJM 13 Properties Ltd | Real estate | 2023 |
| EK Psychotherapies Ltd | Health & social care | 2022 |
| Ekbyz Property Ltd | Real estate | 2025 |
| EKO SB Holdings Limited | Professional & scientific | 2019 |
| Elca Consultancy Limited | Professional & scientific | 2014 |
| Electric Penguin Digital Limited | Information & communication | 2014 |
| Electro Clean North East Ltd. | Administrative & support | 2000 |
| Elevale Limited | Construction | 2013 |
| Elevate Inspire Ltd | Professional & scientific | 2025 |
| Ella Court (Kirk Ella) R.T.M Company Ltd | Professional & scientific | 2012 |
| Ellow Holdings Ltd | Financial services | 2026 |
| Elsham Linc Limited | Agriculture & fishing | 2005 |
| Emergency Prepare Limited | Professional & scientific | 2026 |
| Emmanuel Bortey Alabi Limited | Health & social care | 2011 |
| END Energy Poverty CIC | Professional & scientific | 2024 |
| Enguard Training and Security Ltd | Administrative & support | 2025 |
| Epms Property Limited | Real estate | 2021 |
| Equilibrium Services Ltd | Professional & scientific | 2019 |
| Erlinda Jelita Spa Limited | Other services | 2013 |
| Escape Room (Hull) Limited | Arts & recreation | 2018 |
| Eskimosoup Limited | Professional & scientific | 2012 |
| Essential Estates Limited | Construction | 2003 |
| Essential Funding Limited | Financial services | 2013 |
| Essential Heating Services Limited | Construction | 2020 |
| Essential Homes U.K. Limited | Construction | 2017 |
| Essential HSE Limited | Professional & scientific | 2016 |
| Essential Leisure Limited | Extraterritorial | 2005 |
| Estates GB 2 Ltd | Real estate | 2020 |
| Estates GB Ltd | Real estate | 2009 |
| Estates U.K. Limited | Real estate | 1998 |
| Estates UK (Maintenance) Limited | Real estate | 2004 |
| ETC Cares Ltd | Health & social care | 2022 |
| Evergreen Products (Yorkshire) Limited | Wholesale & retail | 2025 |
| Eversley House Management Limited | Real estate | 2006 |
| Ewens Limited | Professional & scientific | 2005 |
| Exbow Limited | Professional & scientific | 2019 |
| Exclusive Acquisitions Ltd | Real estate | 2023 |
| Expotrak Limited | Water & waste | 1971 |