| Riverside Vehicle Wash Limited | Administrative & support | 2010 |
| Riverview Properties (U.K.) Limited | Real estate | 2022 |
| RJG Signs Limited | Manufacturing | 2002 |
| RJS Project Solutions Ltd | Professional & scientific | 2024 |
| RM Property Services Hull Ltd | Water & waste | 2025 |
| RMS Europe Group Limited | Professional & scientific | 2004 |
| RMS Goole Limited | Transport & logistics | 1990 |
| RMS Grimsby Limited | Transport & logistics | 1990 |
| RMS Group Holdings Limited | Extraterritorial | 2019 |
| RMS Hull Limited | Transport & logistics | 2005 |
| RMS Ports Limited | Professional & scientific | 2007 |
| RMS Trent Ports Limited | Transport & logistics | 1936 |
| Roast Grind Brew Ltd | Hospitality | 2024 |
| Robert Farrow Design Limited | Professional & scientific | 1984 |
| Rockliffe Court Limited | Health & social care | 2013 |
| Rockliffe House Limited | Health & social care | 2003 |
| Rocola Limited | Professional & scientific | 2017 |
| Rodmell Limited | Construction | 2015 |
| Rontech Services Ltd | Professional & scientific | 2026 |
| Roodog Limited | Wholesale & retail | 2013 |
| Rosedale Homes Ltd | Real estate | 2026 |
| RPM Electrical (East Yorkshire) Limited | Construction | 2007 |
| Rubbishman Ltd | Water & waste | 2025 |
| Rudstons of Hessle Limited | Other services | 2016 |
| Rush Leisure Ltd | Arts & recreation | 2025 |
| Rute Education Ltd | Education | 2025 |
| S & P Scaffolding Limited | Construction | 2009 |
| S Morris Projects Ltd | Construction | 2018 |
| S&H MEP Ltd | Construction | 2020 |
| S&R Mann Ltd | Real estate | 2024 |
| S.A.F.E Accommodation Ltd | Real estate | 2021 |
| S.U.S. Industries Limited | Information & communication | 2020 |
| SA Professional Ltd | Health & social care | 2023 |
| Safeprep Ltd | Information & communication | 2026 |
| Saffron Training Limited | Professional & scientific | 2014 |
| Sagres Properties Limited | Households | 2025 |
| Sailors' Children's Society | Health & social care | 1919 |
| Salt Digital Marketing Limited | Information & communication | 2017 |
| Sandhill Nurseries and Garden Centre Limited | Wholesale & retail | 1997 |
| Savage Sutton Ltd | Administrative & support | 2016 |
| SB Cine Limited | Information & communication | 2025 |
| Scandinavian Property Solutions Ltd | Real estate | 2025 |
| School Radio Ltd | Information & communication | 2015 |
| Scientific Laboratory Supplies Group Ltd | Wholesale & retail | 2016 |
| Scientific Laboratory Supplies Limited | Wholesale & retail | 1991 |
| Scorpion Technical Ltd | Information & communication | 2022 |
| Scram Ltd | Professional & scientific | 2025 |
| Seagold Limited | Wholesale & retail | 1996 |
| Seathorn Facilities & Landscaping Ltd | Administrative & support | 2018 |
| Second Leisure Limited | Hospitality | 2014 |
| Secupro Ltd | Administrative & support | 2026 |
| Send IT Stunts Limited | Arts & recreation | 2024 |
| Sewell Contractors Limited | Construction | 2025 |
| Shades by Lord Ltd | Other services | 2025 |
| Shanghai West Ltd | Hospitality | 2024 |
| Shardeloes Court (Cottingham) R.T.M Company Ltd | Professional & scientific | 2012 |
| Sheilds Limited | Education | 2002 |
| Sherol Limited | Administrative & support | 2022 |
| Sherwood Holidays Limited | Hospitality | 2026 |
| Shields Electrical Limited | Construction | 2003 |
| Shreeve Commerce Ltd | Wholesale & retail | 2024 |
| Siatos Medical Limited | Health & social care | 2023 |
| Signal Growth Ltd | Administrative & support | 2011 |
| Simpla Solutions Limited | Information & communication | 2011 |
| Simply Students (Hull) Limited | Real estate | 2015 |
| Sjsf Enterprises Ltd | Hospitality | 2019 |
| SK Hessle Ltd | Wholesale & retail | 2023 |
| SK Shift Motors Ltd | Wholesale & retail | 2025 |
| Skeltons and Co Limited | Manufacturing | 2007 |
| Skilldent Ltd | Health & social care | 2023 |
| Skipness Road Developments Limited | Construction | 2025 |
| Skye Revive & Rent Ltd | Real estate | 2024 |
| SLB Retail Ltd | Wholesale & retail | 2023 |
| Slew Left Limited | Mining & quarrying | 2019 |
| Smart Technology Advisers Ltd | Professional & scientific | 2012 |
| SMH Business Consultancy Limited | Professional & scientific | 2016 |
| Smith & Holtby Property Solutions Ltd | Construction | 2024 |
| Smithson Evans Paediatric Neuropsychology Limited | Health & social care | 2025 |
| Snuglife Property Ltd | Real estate | 2025 |
| SO Matters Ltd | Professional & scientific | 2025 |
| Sobec Contracting Ltd | Construction | 2017 |
| Soff Lane Properties Limited | Transport & logistics | 2015 |
| Solus Group Holdings Limited | Financial services | 2024 |
| Soma 1982 Ltd | Hospitality | 2024 |
| Songbird Limited | Hospitality | 1999 |
| Sonshine Productions Limited | Information & communication | 2020 |
| Sorted Utilities Limited | Professional & scientific | 2017 |
| Sotr Group Limited | Financial services | 2024 |
| Sound Production Design Limited | Manufacturing | 2023 |
| Sound Solutions Advertising Limited | Professional & scientific | 1996 |
| Source Locums Limited | Administrative & support | 2025 |
| Southfield Parklands Limited | Households | 2011 |
| Southrise Investments Limited | Financial services | 2023 |
| Sowden & Sowden Limited | Professional & scientific | 1986 |
| Space Male Image Ltd | Other services | 2022 |
| Spc.Moda Limited | Wholesale & retail | 2011 |
| Spencer Grey Consulting Ltd | Professional & scientific | 2025 |
| Spicer Rental Properties Ltd | Real estate | 2022 |
| Sportsrule Ltd | Professional & scientific | 2012 |
| Springfield Garage (Hull) Ltd | Wholesale & retail | 2010 |