| Soft Play POP UP Parties Ltd | Arts & recreation | 2025 |
| Soigné Pubs Ltd | Financial services | 2023 |
| Sojo Kitchen Catering & Events Limited | Hospitality | 2021 |
| Solidart Limited | Professional & scientific | 2009 |
| Solihull Moors Investments Limited | Financial services | 2020 |
| Somerset House (Wivelsfield) Management Ltd | Households | 2025 |
| Something Dull Ltd | Administrative & support | 2019 |
| Sonoma Solutions Ltd | Information & communication | 2011 |
| Sophie Whitworth Coaching Ltd | Education | 2017 |
| Sounds Positive Ltd | Information & communication | 2004 |
| Southern Medical Rescue Ltd | Other services | 2019 |
| Southern Plant & Tool Hire Limited | Administrative & support | 1998 |
| Southern Specialist Vehicle Services Ltd | Other services | 2023 |
| Southfield Park (Oxford) Management Company Limited | Households | 1973 |
| SPB Precision Engineering Limited | Manufacturing | 2023 |
| Speakeasy Spirits Limited | Wholesale & retail | 2025 |
| Speakers at the Limits Ltd. | Professional & scientific | 2017 |
| Spectacular Group Ltd | Professional & scientific | 2022 |
| SPH Management Company Limited | Real estate | 2021 |
| Spider's Workshop Ltd | Wholesale & retail | 2020 |
| Spin Planning Limited | Professional & scientific | 2020 |
| Spitfire Consulting Limited | Information & communication | 2012 |
| Splendid Leads Ltd | Professional & scientific | 2019 |
| Splendid Websites Limited | Information & communication | 2022 |
| Spod Properties Ltd | Real estate | 2020 |
| Spratley & Partners Group Holdings Limited | Professional & scientific | 2023 |
| Spratley & Partners Limited | Professional & scientific | 2008 |
| Spring Capital Limited | Financial services | 2025 |
| Springboard Success Ltd | Administrative & support | 2020 |
| Springhill Enterprises Limited | Administrative & support | 1990 |
| Springhill Rural Enterprises Limited | Professional & scientific | 1958 |
| Springwood Land and Development Limited | Real estate | 1987 |
| Springwood Marketing Limited | Professional & scientific | 2014 |
| Square Perch Ltd | Financial services | 2026 |
| Squeezy Media Ltd | Information & communication | 2016 |
| SR Aeroservices Limited | Other services | 2015 |
| SR Aviation Limited | Manufacturing | 2004 |
| Srxis Capital Partners Ltd | Construction | 2023 |
| ST Ebba's Management NO 1 Limited | Households | 2010 |
| ST Ebba's Management NO 2 Limited | Households | 2010 |
| ST Marys Court Henley Management Limited | Administrative & support | 2013 |
| ST Peters Court (Chalfont ST Peter) Limited | Households | 2017 |
| ST. Mary's (Wantage) Management Company (2) Limited | Professional & scientific | 2007 |
| ST. Mary's (Wantage) Management Company Limited | Households | 2008 |
| Stag and Huntsman Hambleden Ltd | Hospitality | 2023 |
| Stag and Huntsman Limited | Wholesale & retail | 2019 |
| Stag Owners Club Tooling Fund Limited | Administrative & support | 1991 |
| Stage Burrows Limited | Professional & scientific | 2020 |
| Starfish FX Limited | Administrative & support | 2024 |
| Starling & Stokes Ltd | Administrative & support | 2021 |
| Starvale Property Company Limited | Administrative & support | 1999 |
| Station Road News Limited | Wholesale & retail | 2020 |
| Steel Core Fabrications Limited | Construction | 2026 |
| Steffi Freund Limited | Professional & scientific | 2022 |
| Stelar Cleaning Services Limited | Administrative & support | 2015 |
| Stellar Tech Labs Ltd | Information & communication | 2025 |
| Stem Nutrition Ltd | Professional & scientific | 2019 |
| Stenosphere Ltd | Extraterritorial | 2023 |
| Step Finance Limited | Financial services | 2018 |
| Stephen Davies Landscape Limited | Professional & scientific | 2005 |
| Stephen J Pain Consulting Ltd | Professional & scientific | 2022 |
| Steve Weiser Limited | Information & communication | 2007 |
| Steve Williams Limited | Professional & scientific | 2005 |
| Stewart Stables Ltd | Agriculture & fishing | 2026 |
| Stimulus Creative Ltd | Administrative & support | 2017 |
| Stoke ROW Garage Ltd | Wholesale & retail | 2009 |
| Stoke ROW Store Limited | Wholesale & retail | 2016 |
| Stone Sports Strategy Limited | Professional & scientific | 2026 |
| Stonebridge Business Solutions Ltd | Administrative & support | 2017 |
| Stonemason's Court (Long Hanborough) Limited | Households | 2021 |
| Stonor Enterprises LLP | | 2025 |
| Stoptide Investments Limited | Financial services | 2015 |
| Stow House Associates Limited | Professional & scientific | 2022 |
| Stowell Associates Ltd | Professional & scientific | 2021 |
| Strategic Social Limited | Professional & scientific | 2025 |
| Straththames Limited | Mining & quarrying | 2009 |
| Strativate Ltd | Information & communication | 2025 |
| Stream Farm Holdings Limited | Education | 2020 |
| Stream Farm Operations Limited | Agriculture & fishing | 2020 |
| Streamline Peppard Cars Limited | Transport & logistics | 2018 |
| Streatley Limited | Professional & scientific | 2002 |
| Strolleazi UK Ltd | Wholesale & retail | 2019 |
| Strongcast Consulting Limited | Professional & scientific | 2010 |
| Stuart Woollford Ltd | Professional & scientific | 2026 |
| Studio Ember Limited | Professional & scientific | 2021 |
| Studio Hayes Limited | Professional & scientific | 2023 |
| Suas Limited | Extraterritorial | 2009 |
| SUE Ryder Prayer Fellowship (Parmoor) | Other services | 2010 |
| Summit Well Delivery Limited | Professional & scientific | 2019 |
| Sumner House Management Company Limited | Households | 2016 |
| Sunfish Limited | Other services | 1996 |
| Sunlight Pictures Ltd | Information & communication | 2012 |
| Supportworks Ltd | Information & communication | 2025 |
| Supreme Gates Limited | Manufacturing | 2013 |
| Surgic-Air Limited | Manufacturing | 2017 |
| Surrey Hills FX Limited | Administrative & support | 2023 |
| Susie Pragnell Ltd | Real estate | 2022 |
| Suspense International Ltd | Wholesale & retail | 2024 |
| Sustainability Verified Ltd | Information & communication | 2025 |
| Sustainable Clean Fuels Limited | Manufacturing | 2017 |