| Stephen Austin Design Ltd | Wholesale & retail | 2015 |
| Sterling Independent Advisers LLP | | 2007 |
| Steve Power Electrical Services Ltd | Construction | 2025 |
| Steven Global Medical Ltd | Wholesale & retail | 2017 |
| Steven Tinkler Design Ltd | Professional & scientific | 2025 |
| Stevens Scanlan the Deck Limited | Households | 2006 |
| Stewart Industries London Limited | Wholesale & retail | 2014 |
| Steyer Ltd | Manufacturing | 2019 |
| Stick Mark Boom Limited | Education | 2015 |
| Sticky Spoon Ltd | Manufacturing | 2023 |
| STILES4DOGS Limited | Extraterritorial | 2024 |
| Stillness in Sound UK Ltd | Health & social care | 2026 |
| Stiwdios Morgen Ltd | Professional & scientific | 2023 |
| Stockley Investments Limited | Real estate | 2011 |
| Stoke-On-Trent Hotel Opco Limited | Financial services | 2025 |
| Stoke-On-Trent Hotel Propco Limited | Financial services | 2025 |
| Stomp Dance & Sports LLP | | 2018 |
| Stone AGE Installations Ltd | Construction | 2005 |
| Stone AGE Limited | Construction | 2002 |
| Stone AGE Private Limited | Construction | 2019 |
| Stone AGE PVT Limited | Construction | 2019 |
| Stone Cottage Consultancy Ltd | Professional & scientific | 2016 |
| Stone Hill Meadow Management Company Limited | Households | 2022 |
| Stonefield Solutions Limited | Administrative & support | 2025 |
| Stonehouse Consolidated Limited | Professional & scientific | 2012 |
| Stonehurst Property Solutions Limited | Real estate | 2025 |
| Stonerock Advisors Ltd | Information & communication | 2013 |
| Storage Motion (UK) Limited | Manufacturing | 2015 |
| Storagemaker Limited | Wholesale & retail | 2025 |
| Stork Plumbing & Heating Ltd | Construction | 2021 |
| Storm Basketball Community Interest Company | Arts & recreation | 2012 |
| Storm Standard Ltd | Wholesale & retail | 2026 |
| Story Boat Tales Limited | Arts & recreation | 2014 |
| Stotfold Park Management Company Limited | Households | 2020 |
| Stpn Ltd | Real estate | 2024 |
| Strahil Vasilev Ltd | Real estate | 2025 |
| Strand Residents Limited | Households | 1999 |
| Strata Services Ltd | Information & communication | 2002 |
| Strategic Test Consulting Ltd | Information & communication | 2013 |
| Strategicsiq Ltd | Administrative & support | 2025 |
| Straw Private Accountants Limited | Manufacturing | 2025 |
| Strawberry Fields (Kendal) Management Company Limited | Real estate | 2016 |
| Strawberry Fields (Westoning) Management Company Limited | Households | 2025 |
| Strawberry Local Ltd | Wholesale & retail | 2014 |
| Stray Basilisk Ltd | Information & communication | 2018 |
| Streak Tech Limited | Information & communication | 2025 |
| Street Scaffolding Services Ltd | Construction | 2025 |
| Strive Broking Group Limited | Financial services | 2025 |
| Strive Staffing Solutions Ltd | Administrative & support | 2024 |
| Strive Stone Construction Limited | Information & communication | 2012 |
| Strive to Inspire Education Limited | Education | 2013 |
| Strongman Solutions Limited | Health & social care | 2012 |
| Structa LLP | | 2004 |
| Structure Works International Limited | Construction | 2017 |
| Studio Apollo Limited | Manufacturing | 2012 |
| Studio Peckham Ltd. | Professional & scientific | 2024 |
| Studio Vibe Ltd | Information & communication | 2025 |
| STUDIO630 Ltd | Real estate | 2024 |
| Stuntsort Limited | Construction | 1987 |
| Stuntz Ltd | Arts & recreation | 2013 |
| Style Hair and Beauty (Wing) Limited | Other services | 2011 |
| Styling Android Limited | Information & communication | 2014 |
| Subcity Property Services Ltd | Construction | 2013 |
| Subcon Drilling Ltd | Manufacturing | 2001 |
| Subdrive Limited | Wholesale & retail | 2012 |
| Subject Matters Ltd | Other services | 2001 |
| Subline Events Ltd | Administrative & support | 2025 |
| Subtletee Ltd | Wholesale & retail | 2025 |
| Sudha Software Limited | Information & communication | 2021 |
| SUF Ltd | Professional & scientific | 2024 |
| Sugar Bush Ltd | Professional & scientific | 2024 |
| Sugne Jewellery Ltd | Wholesale & retail | 2021 |
| SUJ Technologies Ltd | Information & communication | 2012 |
| Sule Limited | Hospitality | 2025 |
| Sulvie Green Farm Ltd | Agriculture & fishing | 2023 |
| Sumita Shah Consultancy Ltd | Professional & scientific | 2020 |
| Summer Globe Investments Ltd | Wholesale & retail | 2025 |
| Summer House Salon Ltd | Other services | 2023 |
| Summit Health Hemel Hempstead Ltd | Health & social care | 2026 |
| Sumo JOE Limited | Professional & scientific | 2022 |
| Sun Haven Holiday Park Ltd | Arts & recreation | 2019 |
| Sun Junkies Herts Ltd | Administrative & support | 2011 |
| Sun Leader UK Ltd | Construction | 2025 |
| Sundae in London Limited | Wholesale & retail | 2025 |
| Sungrid Limited | Wholesale & retail | 2013 |
| Sunnastays Ltd | Administrative & support | 2026 |
| Sunny K Ltd | Construction | 2017 |
| Sunrise Hire Ltd | Administrative & support | 2024 |
| Super Happy Windows Limited | Administrative & support | 2024 |
| Superheroes Limited | Education | 2016 |
| Supply TCG Limited | Wholesale & retail | 2025 |
| Support to Live at Home Ltd | Information & communication | 2026 |
| Supporting Links Limited | Education | 2011 |
| Supreme Garage Ltd | Wholesale & retail | 2020 |
| Surma Hemel Ltd | Hospitality | 2025 |
| Surpan Limited | Information & communication | 2017 |
| Surulere Limited | Hospitality | 2020 |
| Sushi SHO Restaurant Limited | Hospitality | 2025 |
| Sutton Court (Guildford) Limited | Households | 1973 |
| Sutton Court RTM Company Limited | Households | 2022 |