| ROY Broad Haulage Limited | Transport & logistics | 2019 |
| Rozen (Cornwall) Limited | Financial services | 2023 |
| Rozen Furniture (Holdings) Limited | Professional & scientific | 2003 |
| Rozen Furniture Limited | Manufacturing | 1997 |
| Runic Communications Limited | Professional & scientific | 2022 |
| Rupert Hitchcox Photography Limited | Professional & scientific | 2005 |
| Rusmar Developments Ltd | Construction | 2017 |
| Russell Davis Limited | Health & social care | 2014 |
| RW Groundworks & Civil Engineering Limited | Construction | 2025 |
| S&Gs Engineering Ltd | Manufacturing | 2019 |
| S.C.Roofing Southwest Ltd | Construction | 2022 |
| S.P. & M.L. Neal Consultancy Limited | Administrative & support | 2011 |
| Sacred Sanctuary CIC | Health & social care | 2023 |
| SAF Cury Ltd | Professional & scientific | 2011 |
| Saffron Rambling Ltd | Transport & logistics | 2013 |
| Sailaway Properties Ltd | Real estate | 2023 |
| Sally Tully Ceramics Ltd | Manufacturing | 2021 |
| Samphire Marketing + Web Ltd | Administrative & support | 2019 |
| Sams Cornwall Limited | Professional & scientific | 2019 |
| Sanzaru Ltd | Other services | 2018 |
| Sarah Johnson Design Limited | Professional & scientific | 2020 |
| Sarah Osborne Limited | Households | 2026 |
| Sarah's Bookkeeping Cornwall Limited | Professional & scientific | 2022 |
| Satco Infrastructure UK Ltd | Information & communication | 2025 |
| Satya Films Ltd | Information & communication | 2018 |
| Savage Clothing Ltd | Manufacturing | 2017 |
| Sawyers Court Management Company Limited | Households | 1986 |
| Sc-Uba/Design Services Limited | Administrative & support | 2008 |
| Scarlet Imprint Limited | Information & communication | 2007 |
| Scorpion Security Southwest Ltd | Administrative & support | 2025 |
| Scorse Foods Ltd | Manufacturing | 2000 |
| Scott Hesketh Design Limited | Professional & scientific | 2000 |
| Scuba RY Divers Ltd | Wholesale & retail | 2024 |
| Sea Breeze Solutions Limited | Professional & scientific | 2024 |
| Seadog Properties Ltd | Real estate | 2019 |
| Seadrift Porthleven Limited | Hospitality | 2019 |
| Seafit Marine Services Limited | Manufacturing | 2002 |
| Sean's Removals Ltd | Transport & logistics | 2024 |
| Seaside Food Limited | Real estate | 2016 |
| Seaside Weddings Ltd | Administrative & support | 2008 |
| Seawide Enterprises Limited | Extraterritorial | 1991 |
| Seawide Services Limited | Administrative & support | 1973 |
| Seed Accounting Ltd | Professional & scientific | 2019 |
| Serenity Lounge Hair and Beauty Limited | Other services | 2018 |
| Serpentine Hospitality Ltd | Hospitality | 2025 |
| Serpentine Software Limited | Information & communication | 2000 |
| Sharp Image Productions Limited | Information & communication | 1994 |
| Shifty PIG Ltd | Agriculture & fishing | 2019 |
| Shiloh House Management Company Limited | Households | 2018 |
| Shoals Drinks Ltd | Wholesale & retail | 2022 |
| Shore FIX Construction Limited | Construction | 2012 |
| Shrubberies Hill Management Company Limited | Real estate | 2014 |
| Shute Hill Management Services Limited | Households | 2014 |
| Signature Space Cornwall Ltd | Real estate | 2026 |
| Silvolutions Hypnotherapy Limited | Health & social care | 2021 |
| Simply Kind Ltd | Administrative & support | 2023 |
| Simply Weddings and Events Limited | Administrative & support | 2016 |
| Singletonslade LLP | | 2014 |
| Sinikas Property Management Limited | Real estate | 2025 |
| Sirkenneth Ltd | Hospitality | 2024 |
| SKI IT Limited | Information & communication | 2006 |
| Skova Outdoors Ltd | Manufacturing | 2019 |
| Skovva Consultancy Services Limited | Professional & scientific | 2026 |
| SM Cleaning Ltd | Administrative & support | 2009 |
| Smart Maintenance Systems Ltd | Information & communication | 2025 |
| Smart Marine Electrical Ltd | Manufacturing | 2025 |
| Smoke N Grill Live Fire Kitchen Limited | Hospitality | 2026 |
| Socol Property Ltd | Real estate | 2025 |
| Softgreen Limited | Manufacturing | 1979 |
| Solis Design and Build Ltd | Other services | 2020 |
| Somerset and Dorset Railway Restoration Trust | Extraterritorial | 1998 |
| Songhurst Print Ltd | Manufacturing | 2020 |
| Souls Cycles Ltd | Manufacturing | 2025 |
| South Coast Hydrographic Services Ltd | Professional & scientific | 2018 |
| South Cornwall Caretakers Limited | Administrative & support | 2009 |
| South Kerrier Alliance Community Interest Company | Other services | 2008 |
| South Kerrier Primary Care Ltd | Health & social care | 2020 |
| South West Assured Ltd | Professional & scientific | 2025 |
| South West Comms Limited | Information & communication | 2016 |
| South West Electrical Systems Limited | Construction | 2018 |
| South West Electrotechnical Services Ltd | Manufacturing | 2018 |
| South West Fitness Limited | Arts & recreation | 2014 |
| South West Garage Doors Limited | Construction | 2003 |
| South West Loos Ltd | Administrative & support | 2026 |
| South West Sherpas Ltd | Transport & logistics | 2017 |
| Southerly Point Co-Operative Educational Trust | Education | 2009 |
| Southern Cross Building and Construction Services Ltd | Construction | 2015 |
| Southern Hospitality and Catering Ltd | Hospitality | 2024 |
| Southwest Masonry and Roofing Ltd. | Construction | 2017 |
| Spicy Spicers Ltd | Hospitality | 2024 |
| Spiral Construction Trustees Limited | Professional & scientific | 2025 |
| Spitfire Trust | Other services | 2014 |
| Squirrel Developers Ltd | Construction | 2026 |
| SR Woodburning Ltd | Construction | 2015 |
| Ssck Services Limited | Professional & scientific | 2008 |
| ST Erbyns Company Limited | Professional & scientific | 2004 |
| ST Ives Custom House Ltd | Hospitality | 2021 |
| ST Margarets Woodlands (Carbis Bay) Limited | Real estate | 2018 |
| ST Marys Riding Centre Limited | Arts & recreation | 2012 |
| Stainless Vehicle Products Ltd | Wholesale & retail | 2023 |