| SB Tech LAB Limited | Wholesale & retail | 2025 |
| SBX Services Limited | Professional & scientific | 2022 |
| SC Pension Solutions Limited | Professional & scientific | 2015 |
| Scotia PUB Management Limited | Hospitality | 2005 |
| Seedtree Accountant Limited | Professional & scientific | 2023 |
| Seedtree Fitness Limited | Health & social care | 2026 |
| Select Euro Track Days Limited | Transport & logistics | 2011 |
| Seven Group CS Limited | Wholesale & retail | 2026 |
| SH Building Services (NE) Ltd | Real estate | 2025 |
| Shea Hair Nails Beauty and Spa Limited | Other services | 2013 |
| Shelley & SON Ltd | Real estate | 2024 |
| Shield Motor Company Ltd | Wholesale & retail | 2022 |
| Shield Trade Frames N E Limited | Construction | 2015 |
| Shields Scaffolding Ltd | Construction | 2024 |
| Silver Cleaning Service Ltd | Administrative & support | 2026 |
| Simply Builds and Stoves NE Ltd | Wholesale & retail | 2025 |
| Simply Stoves Installations Ltd | Construction | 2025 |
| Simply Stoves Installations WG Ltd | Construction | 2025 |
| Singh's Best One Ltd | Wholesale & retail | 2025 |
| Sixteen Enterprises Ltd | Hospitality | 2024 |
| SJF Offshore Ltd | Construction | 2019 |
| SJH Design Solutions Ltd | Professional & scientific | 2014 |
| SKI Sun Holidays Limited | Administrative & support | 2008 |
| Skin and Body Revitalising Clinic Ltd | Other services | 2025 |
| SM Courier Services Limited | Transport & logistics | 2021 |
| SMC Investment Group Limited | Real estate | 2023 |
| Smile Services Limited | Health & social care | 2017 |
| Smith Bros (Hebburn & Jarrow) Limited | Manufacturing | 1922 |
| Sora Consulting Limited | Professional & scientific | 2010 |
| Sora Services Limited | Professional & scientific | 2010 |
| South Tyneside Academy of Musical Performance Community Interest Company | Arts & recreation | 2006 |
| South Tyneside Co-Operative Special School Trust | Education | 2011 |
| South Tyneside Community Land CIC | Real estate | 2010 |
| South Tyneside Community Laundry C.I.C. | Other services | 2013 |
| South Tyneside Kettlebells Limited | Other services | 2013 |
| South West Logistics Ltd | Transport & logistics | 2021 |
| Sport Life North East Limited | Arts & recreation | 2024 |
| Springwell Equestrian Centre Ltd | Agriculture & fishing | 2023 |
| SRG Dhadda Ltd | Real estate | 2022 |
| Staples Engineering Ltd | Construction | 2024 |
| Stapplinks Ltd | Information & communication | 2017 |
| Stellar Engineering Solutions Ltd | Professional & scientific | 2023 |
| Stellar Recruitment Ltd | Administrative & support | 2024 |
| Storm Tempest Limited | Construction | 2005 |
| STR Site Management Ltd | Construction | 2022 |
| Structure Wise Consulting Ltd | Professional & scientific | 2026 |
| Stuart Owen Norton Glass & Sign Limited | Manufacturing | 1995 |
| Suckonmesweets Ltd | Wholesale & retail | 2023 |
| Sunny Nails Spa Ltd | Other services | 2022 |
| Superior Steel Services Limited | Professional & scientific | 2016 |
| T a Renewables Ltd | Construction | 2019 |
| T.E.D GAS Ltd | Construction | 2020 |
| T11LOY Ltd | Financial services | 2020 |
| T2LYY Ltd | Financial services | 2019 |
| Tanhills Design and Construction Ltd | Construction | 2023 |
| Tatum Leisure Services Limited | Hospitality | 2014 |
| TB Wind Services Ltd | Professional & scientific | 2025 |
| Tech Pump Ltd | Other services | 2011 |
| Tech Scape Hub Limited | Wholesale & retail | 2024 |
| Techniko Industrial Products Ltd | Manufacturing | 2017 |
| Temple Aesthetics NE Ltd | Other services | 2024 |
| TEN North East Limited | Health & social care | 1994 |
| Testcity Limited | Real estate | 2026 |
| Tetallex Consulting Limited | Administrative & support | 2017 |
| TGS Auto Limited | Wholesale & retail | 2016 |
| Thai Therapy Body & Mind Limited | Other services | 2025 |
| THE 8 Planets Ltd | Information & communication | 2019 |
| THE Allure Group Ltd | Other services | 2020 |
| THE Balti Masters Limited | Hospitality | 2007 |
| THE Castle Building Services Organisation Limited | Construction | 2012 |
| THE Castle Wood Group Ltd | Construction | 2024 |
| THE Community Network (NE) CIC | Arts & recreation | 2015 |
| THE Crescent Hair & Beauty Limited | Other services | 2008 |
| THE Dog Salon Ltd | Other services | 2024 |
| THE Educational Guidance Service Ltd | Administrative & support | 2004 |
| THE Hebburn Turkish Barbers Ltd | Other services | 2017 |
| THE Neurothentic Network CIC | Education | 2024 |
| THE New Kelly Deli Ltd | Hospitality | 2020 |
| THE Property Purveyors Ltd | Real estate | 2022 |
| THE Reptile Hotel Limited | Wholesale & retail | 2023 |
| THE Sculpting Clinic Limited | Other services | 2024 |
| THE Sustainability Accountants Limited | Professional & scientific | 2022 |
| THE Wheels Project (South Tyneside) | Wholesale & retail | 2008 |
| Third Principle Academy Ltd | Arts & recreation | 2022 |
| Thomas Bensley Plant Services Limited | Construction | 2016 |
| Tidy Scaffolding Ltd | Construction | 2019 |
| TJ Coaching Ltd | Arts & recreation | 2021 |
| Tkac Holdings Limited | Financial services | 2010 |
| Top Spec Environmental Services Limited | Water & waste | 2014 |
| Topfellas Food Ltd | Hospitality | 2021 |
| Topfellas Ltd | Hospitality | 2018 |
| Trade Installations North East Limited | Construction | 2019 |
| Tradetechai Ltd | Information & communication | 2026 |
| Transformation 540 Limited | Information & communication | 2022 |
| Transmission and Distribution Engineering Services Ltd | Energy | 2017 |
| Transmission Engineering Services Holdings Limited | Financial services | 2026 |
| Transmission Engineering Services Limited | Professional & scientific | 2020 |
| Tree Stump Theatre Limited | Arts & recreation | 2022 |
| True Moon Pictures Ltd | Information & communication | 2024 |
| Turnkey Air Conditioning Limited | Construction | 1998 |