| Dhammakaya North United Kingdom | Other services | 2007 |
| Diamond Joinery and Kitchens Ltd | Construction | 2022 |
| Discover Elearning Ltd | Information & communication | 2016 |
| DJP Electrical Limited | Construction | 2017 |
| DJP Ventures Ltd | Other services | 2011 |
| DM Engineering Construction Ltd | Construction | 2025 |
| DMT Management Ltd | Professional & scientific | 2024 |
| DNA Dynamic Limited | Professional & scientific | 2024 |
| Dodify Ltd | Information & communication | 2012 |
| Domaco Ltd | Wholesale & retail | 2025 |
| Dormouse Ltd | Real estate | 2014 |
| Dottir Strength and Fitness Community Interest Company | Health & social care | 2023 |
| Dottir Strength, Fitness and Wellbeing Ltd | Arts & recreation | 2025 |
| Dougies Tavern Ltd | Hospitality | 2019 |
| Draft Circle Limited | Professional & scientific | 2015 |
| Drbm Consultancy Limited | Professional & scientific | 2001 |
| Dream Works Design Ltd | Information & communication | 2020 |
| Drive Automotive NE Ltd | Wholesale & retail | 2024 |
| DTL Worksurfaces Ltd | Manufacturing | 2024 |
| Duggza Electrics Ltd | Construction | 2015 |
| Dynamic DNA Limited | Professional & scientific | 2024 |
| Dynamics Therapy Co Ltd | Health & social care | 2022 |
| E & D Chambers Enterprises Limited | Real estate | 2024 |
| E W Flowers Ltd | Wholesale & retail | 2026 |
| E-Quality Learning Limited | Education | 2010 |
| EB Capital Investments Limited | Financial services | 2025 |
| EBUY360 Ltd | Wholesale & retail | 2020 |
| Eco Plumbing (NE) Limited | Construction | 2026 |
| Ecologic Solutions Ltd | Administrative & support | 2020 |
| Eeslc Ltd | Construction | 2025 |
| Ejmc Consulting Ltd | Education | 2014 |
| Elaine Ingram Leisure Limited | Other services | 2016 |
| Elcomesoft Ltd | Wholesale & retail | 2023 |
| Electrex Ltd. | Professional & scientific | 2014 |
| Elite Enclosures and Fabrications Limited | Manufacturing | 1996 |
| Elite Power Services Ltd | Construction | 2025 |
| Elite Travel Northeast Ltd | Transport & logistics | 2026 |
| Elixir Estate Planning Ltd | Professional & scientific | 2023 |
| Ellison 1965 Limited | Extraterritorial | 2014 |
| Ellison 1966 Limited | Extraterritorial | 2014 |
| Elrae Hair Academy Ltd | Education | 2025 |
| Embrace Talking Therapies Ltd | Health & social care | 2025 |
| Empower Yourself Fully Limited | Information & communication | 2022 |
| EN Piping Sevices Ltd | Professional & scientific | 2025 |
| Energy Windows N E Limited | Manufacturing | 2013 |
| Engineered Air Ltd | Construction | 2024 |
| Enzo Investment Group Ltd | Real estate | 2020 |
| Enzo Property Group Ltd | Real estate | 2022 |
| EQS Bidco Limited | Financial services | 2026 |
| EQS Topco Limited | Financial services | 2026 |
| Equality Solutions Group Limited | Professional & scientific | 2020 |
| Equinox Safety and Compliance Limited | Administrative & support | 2026 |
| ESG (NE) Limited | Administrative & support | 2022 |
| Esley Aggregates Ltd | Wholesale & retail | 2025 |
| Estia 3B Limited | Real estate | 2020 |
| Eurotrans (N.E) Ltd | Transport & logistics | 2026 |
| Everything Bathroom Supplies Ltd | Wholesale & retail | 2025 |
| EWT Services Ltd | Professional & scientific | 2021 |
| Expert Witness Consultancy Limited | Health & social care | 2025 |
| Express Energy Services Ltd | Professional & scientific | 2017 |
| Eyelash BAE Limited | Wholesale & retail | 2019 |
| F & V Mart Ltd | Wholesale & retail | 2025 |
| F.H. Thompson and Sons Limited | Professional & scientific | 1956 |
| FA Beauty Aura Ltd | Other services | 2024 |
| Falmouth Docks and Engineering Company | | 2024 |
| Feed the Wolf Clothing Ltd | Wholesale & retail | 2019 |
| First AID and Safety Training Ltd | Health & social care | 2022 |
| First AID Saves Lives CIC | Education | 2025 |
| First Call Properties Ltd | Other services | 2013 |
| FIVE2EIGHTEEN Consulting Ltd | Health & social care | 2023 |
| Flooring Solutions North East Limited | Construction | 2019 |
| Flyspike Limited | Transport & logistics | 2021 |
| Foley Property Holdings Ltd | Households | 2025 |
| Forever Cleaning Services Limited | Administrative & support | 2023 |
| Forster Property Management Ltd | Real estate | 2022 |
| Future Proof North East Ltd | Construction | 2025 |
| G & a Care Ltd | Health & social care | 2017 |
| G & C Flooring Solutions Ltd | Construction | 2026 |
| G. Alderson Ingredient Supplies Limited | Wholesale & retail | 1981 |
| G. Renewables Ltd | Manufacturing | 2025 |
| G.O Tree Surgery Ltd | Administrative & support | 2020 |
| G.P. Spot on Consultancy Limited | Administrative & support | 2009 |
| Gabriel Consulting Ltd | Information & communication | 2017 |
| GAC83 Services Ltd | Professional & scientific | 2022 |
| Gadget Essentials Ltd | Wholesale & retail | 2020 |
| Gadgets Care Ltd | Wholesale & retail | 2019 |
| Gardens to Gutters Ltd | Administrative & support | 2023 |
| Gareth Howe Hairdressing Limited | Other services | 2025 |
| Gateshead Guppies Ltd | Wholesale & retail | 2026 |
| Gavin Spencer Limited | Professional & scientific | 2022 |
| Gencostyle Ltd | Wholesale & retail | 2025 |
| Gentle Paws Ltd | Professional & scientific | 2019 |
| Geordie Girl Ltd | Education | 2021 |
| Getrained Limited | Education | 2016 |
| Gibson's Removals Limited | Transport & logistics | 2015 |
| Global Access Management Ltd | Construction | 2026 |
| Global Height Specialists Ltd | Other services | 2023 |
| Global Substation Solutions Limited | Construction | 2006 |
| Glow Hair Design Limited | Other services | 2017 |
| Go Leadership Ltd | Professional & scientific | 2025 |